Abstract: Pyrrolidine main protease inhibitors are described that are effective as antiviral compounds.

Abstract: A system for treating open wounds includes a foam material configured for pouring, spraying, injecting or spreading on a wound bed. The foam material can comprise a base component and a curing component, which can be pre-mixed before application, or mixed in situ as the components are being applied to the wound site. A third component can comprise a sacrificial porogen. Foam can be placed in the wound bed as a wound liner on the wound surfaces. An additional foam insulation can provide a foam filler partially contained by the wound liner and generally flush with a patient's epidermis. A method of treating open wounds includes the steps of applying the wound liner and filler components. An optional step comprises covering the wound liner with a semi-permeable (breathable) membrane and mounting inlet and outlet ports thereon for introducing healing compositions as input, and extracting wound exudates as output.