Patents by Inventor Jacob Hald

Jacob Hald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DDR1-mediated cell purification of pancreatic endocrine cells through their progenitors
    Patent number: 8551779
    Abstract: The invention relates to a method of identifying, obtaining and/or quantifying a culture of pancreatic cells selected from the group consisting of ductal/endocrine progenitor cells, endocrine progenitor cells, early endocrine cells, and fully differentiated endocrine cells. Also contemplated is a method of expanding the numbers of such cells as well as sorting such cells. The invention further relates to a selective cell surface marker, DDR1, that permits the selection of a unique subset of cells with pancreatic endocrine progenitor phenotype. Furthermore, the invention relates to isolated cells selected from such cells and compositions thereof.
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: October 8, 2013
    Assignee: Novo Nordisk A/S
    Inventors: Jacob Hald, Ole Dragsbæk Madsen, Palle Serup
  • Use of the extracellular marker DNER for identification and selection of specific pancreatic cells
    Patent number: 8399251
    Abstract: The invention relates to a method of identifying and obtaining cells that have the potential to differentiate into pancreatic cells, having the step of contacting a cell population containing endocrine pre-progenitor cells, endocrine progenitor cells, early endocrine cells, and/or fully differentiated endocrine cells with a DNER binding agent; as well as isolating and/or expanding cells obtained by the method and compositions thereof.
    Type: Grant
    Filed: April 3, 2009
    Date of Patent: March 19, 2013
    Assignee: Novo Nordisk A/S
    Inventors: Jacob Hald, Ole Dragsbæk Madsen, Gérard Gradwohl, Georg Mellitzer
  • G6PC2-Encoded Beta Cell Surface Tags
    Publication number: 20110286977
    Abstract: The invention relates to G6PC2-encoded beta cell surface markers, methods of identifying and obtaining a culture cells comprising fully differentiated beta cells. Also contemplated is a method of sorting such cells, isolated cells and compositions thereof.
    Type: Application
    Filed: September 30, 2009
    Publication date: November 24, 2011
    Applicant: Novo nordisk A/S
    Inventors: Bart Roep, Jacob Hald, Ole Dragsbaek Madsen
  • DNER-MEDIATED CELL PURIFICATION OF PANCREATIC ENDOCRINE PRE-PROGENITOR CELLS AND THEIR PROGENY
    Publication number: 20110020297
    Abstract: The invention relates to a method of identifying and obtaining a culture cells comprising cells selected from the group consisting of endocrine pre-progenitor cells, endocrine progenitor cells, early endocrine cells, and/or fully differentiated endocrine cells. Also contemplated is a method of expanding the number of such cells as well as sorting such cells. In some aspects the invention further relates to a selective cell surface marker, DNER, that permits the selection of a unique subset of cells with endocrine pre-progenitor, endocrine progenitor, early endocrine, and/or fully differentiated endocrine phenotype. In some aspects the selective cell surface marker is selected from the group consisting of DNER, DISP2, SEZ6L2, LRP1 1 and SLC30A8. Furthermore, the invention relates to isolated cells selected from such cells and compositions thereof.
    Type: Application
    Filed: April 3, 2009
    Publication date: January 27, 2011
    Applicant: Novo Nordisk A/S
    Inventors: Jacob Hald, Ole Dragsbaek Madsen, Gérard Gradwohl, Georg Mellitzer
  • DDR1-Mediated Cell Purification of Pancreatic Endocrine Cells Through Their Progenitors
    Publication number: 20110014160
    Abstract: The invention relates to a method of identifying, obtaining and/or quantifying a culture of pancreatic cells selected from the group consisting of ductal/endocrine progenitor cells, endocrine progenitor cells, early endocrine cells, and fully differentiated endocrine cells. Also contemplated is a method of expanding the numbers of such cells as well as sorting such cells. The invention further relates to a selective cell surface marker, DDR1, that permits the selection of a unique subset of cells with pancreatic endocrine progenitor phenotype. Furthermore, the invention relates to isolated cells selected from such cells and compositions thereof.
    Type: Application
    Filed: December 19, 2008
    Publication date: January 20, 2011
    Applicant: Novo Nordisk A/S
    Inventors: Jacob Hald, Ole Dragsbaek Madsen, Palle Serup