Patents by Inventor Jacob Hesterman

Jacob Hesterman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Assessment of labeled probes in a subject
    Patent number: 11484278
    Abstract: Wearable apparatus and method of using same for tracking a labeled probe in a subject are disclosed.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: November 1, 2022
    Assignee: Biogen MA Inc.
    Inventors: Ajay Verma, Jack Hoppin, Jacob Hesterman
  • Estimating pharmacokinetic parameters in imaging
    Patent number: 9572542
    Abstract: A method of estimating a parameter of physiological significance in the central nervous system (CNS) is provided. The method comprises (a) providing one or more images of the brain or cerebral spinal fluid (CSF) in a subject to whom a dose of a contrast agent (CA) has been administered; (b) determining, using a computer equipped with image processing software, the concentration or relative concentration of the agent in a region or regions of interest in the brain or CSF, thereby generating concentration data; (c) describing the time-based behavior of concentrations of CA within the brain or CSF using a pharmacokinetic model that is based on a set of pharmacokinetic model parameters; and (d) fitting, using computer code, the pharmacokinetic model to the concentration data, varying one or more parameters, wherein the best fit estimates a parameter of physiological significance in the CNS.
    Type: Grant
    Filed: June 7, 2013
    Date of Patent: February 21, 2017
    Inventors: Kelly Davis Orcutt, John Hoppin, Jacob Hesterman, Christian Lackas
  • Estimating pharmacokinetic parameters in imaging
    Patent number: 9406119
    Abstract: A method is provided for estimating a parameter of physiological significance. One or more images are provided of a tissue in a subject to whom a dose of a contrast agent (CA) has been administered, using a computer equipped with image processing software, the concentration or relative concentration of the agent in a region or regions of interest in the tissue is determined, thus generating concentration data. The time-based behavior of concentrations of CA within the tissue is determined using a pharmacokinetic model that is based on a set of pharmacokinetic model parameters. Using computer code, the pharmacokinetic model is fit to the concentration data, varying one or more parameters, such that a best fit estimate of a parameter of physiological significance is provided.
    Type: Grant
    Filed: December 8, 2011
    Date of Patent: August 2, 2016
    Assignee: INVICRO, LLC
    Inventors: Kelly Davis Orcutt, John Hoppin, Jacob Hesterman, Christian Lackas
  • ASSESSMENT OF LABELED PROBES IN A SUBJECT
    Publication number: 20160029983
    Abstract: Wearable apparatus and method of using same for tracking a labeled probe in a subject are disclosed.
    Type: Application
    Filed: March 12, 2014
    Publication date: February 4, 2016
    Applicant: Biogen MA Inc.
    Inventors: Ajay Verma, Jack Hoppin, Jacob Hesterman
  • Estimating Pharmacokinetic Parameters in Imaging
    Publication number: 20150297160
    Abstract: A method of estimating a parameter of physiological significance in the central nervous system (CNS) is provided. The method comprises (a) providing one or more images of the brain or cerebral spinal fluid (CSF) in a subject to whom a dose of a contrast agent (CA) has been administered; (b) determining, using a computer equipped with image processing software, the concentration or relative concentration of the agent in a region or regions of interest in the brain or CSF, thereby generating concentration data; (c) describing the time-based behavior of concentrations of CA within the brain or CSF using a pharmacokinetic model that is based on a set of pharmacokinetic model parameters; and (d) fitting, using computer code, the pharmacokinetic model to the concentration data, varying one or more parameters, wherein the best fit estimates a parameter of physiological significance in the CNS.
    Type: Application
    Filed: June 7, 2013
    Publication date: October 22, 2015
    Inventors: Kelly Davis Orcutt, John Hoppin, Jacob Hesterman, Christian Lackas
  • Estimating Pharmacokinetic Parameters in Imaging
    Publication number: 20140321723
    Abstract: A method is provided for estimating a parameter of physiological significance. One or more images are provided of a tissue in a subject to whom a dose of a contrast agent (CA) has been administered, using a computer equipped with image processing software, the concentration or relative concentration of the agent in a region or regions of interest in the tissue is determined, thus generating concentration data. The time-based behavior of concentrations of CA within the tissue is determined using a pharmacokinetic model that is based on a set of pharmacokinetic model parameters. Using computer code, the pharmacokinetic model is fit to the concentration data, varying one or more parameters, such that a best fit estimate of a parameter of physiological significance is provided.
    Type: Application
    Filed: December 8, 2011
    Publication date: October 30, 2014
    Applicant: INVICRO LLC
    Inventors: Kelly Davis Orcutt, John Hoppin, Jacob Hesterman, Christian Lackas