Patents by Inventor Jacob J. Schlesinger

Jacob J. Schlesinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of determining immune enhancement of virus infectivity using Fc receptor-transfected cell lines
    Patent number: 8592163
    Abstract: The present invention relates to a method of detecting immune enhancement of virus infectivity, a method of determining neutralization and immune enhancement of virus infectivity, a method of identifying a virus epitope that displays immune enhancement, a method of identifying a compound that modulates activity of an Fc receptor, and a method of identifying a compound that modulates intracellular signaling of an Fc receptor. DNA constructs, cells, and kits relating to these assays are also disclosed.
    Type: Grant
    Filed: May 31, 2006
    Date of Patent: November 26, 2013
    Assignee: University of Rochester
    Inventors: Jacob J. Schlesinger, Xia Jin, Robert C. Rose, W. W. Shanaka Rodrigo
  • FLAVIVIRUS DOMAIN III VACCINE
    Publication number: 20130295162
    Abstract: The disclosure provides a tetravalent Dengue virus vaccine, and methods of inducing a immune response against a Flavivirus such as Dengue virus 1-4 using the vaccine. The disclosure also provides methods of making a vaccine by introducing into a host cell a transgene that encodes a protein comprising Dengue domain III polypeptides, or, by purified dill polypeptides specific for Dengue serotypes 1-4, Yellow Fever Virus, West Nile Virus, Japanese Encephalitis Virus, and Flaviviruses.
    Type: Application
    Filed: October 3, 2011
    Publication date: November 7, 2013
    Applicant: UNIVERSITY OF ROCHESTER
    Inventors: Jacob J. Schlesinger, Xia Jin, Robert C. Rose, Olivia K.T. Block, W.W. Shanaka I. Rodrigo
  • Enhancing Gene Transfer
    Publication number: 20110081317
    Abstract: Described herein are methods of improving the efficiency of gene transfer for a wide range of applications. Specifically provided are methods of increasing expression of an exogenous gene in a cell by contacting the cell with a vector comprising the exogenous gene and contacting the cell with a proteasome inhibitor, a lysosomal protease inhibitor and/or a microtubule inhibitor. Also provided are methods of delivering an antigen delivery vector to a cell or a subject. Provided are antigen delivery systems and kits comprising an antigen delivery vector and a proteasome inhibitor, a lysosomal protease and/or a microtuhulc inhibitor.
    Type: Application
    Filed: August 8, 2008
    Publication date: April 7, 2011
    Applicant: UNIVERSITY OF ROCHESTER
    Inventors: Stephen Dewhurst, Christine N. Zanghi, Ketna Volcy, Jacob J. Schlesinger
  • METHOD OF DETERMINING IMMUNE ENHANCEMENT OF VIRUS INFECTIVITY USING FC RECEPTOR-TRANSFECTED CELL LINES
    Publication number: 20100190147
    Abstract: The present invention relates to a method of detecting immune enhancement of virus infectivity, a method of determining neutralization and immune enhancement of virus infectivity, a method of identifying a virus epitope that displays immune enhancement, a method of identifying a compound that modulates activity of an Fc receptor, and a method of identifying a compound that modulates intracellular signaling of an Fc receptor. DNA constructs, cells, and kits relating to these assays are also disclosed.
    Type: Application
    Filed: May 31, 2006
    Publication date: July 29, 2010
    Applicant: UNIVERSITY OF ROCHESTER
    Inventors: Jacob J. Schlesinger, Xia Jin, Robert C. Rose, W.W. Shanaka Rodrigo