Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: The invention relates to a lighting unit comprising a power converter for providing a regulated power to a first LED load where the first LED load comprises at least one LED, wherein the first LED load is coupled to the power converter, a series combination of a first capacitor and a first switch coupled in series with each other, wherein the series combination is coupled in parallel with the LED load, wherein the power converter is arranged to operate in a first mode, provide a first amount of the regulated power to the first LED load, and wherein the first switch is closed, and in a second mode, provide a second amount of the regulated power to the first LED load, wherein the second amount of the regulated power to the first LED load is lower than the first amount of the regulated power to the first LED load, and wherein the first switch is opened.

Abstract: A support device for supporting a cable includes a central support portion having a first side and a second side. The support device also includes a first leg portion extending between a first end and a second end, the first leg portion having a first helical winding. The support device also includes a second leg portion extending between a third end and a fourth end, the second leg portion having a second helical winding. The support device further includes a hanger portion attached to the central support portion. The hanger portion includes structure that cooperates with an associated attachment structure. The first leg portion is attached to the central support portion and the second leg portion is attached to the central support portion. The first helical winding and the second helical winding are configured to receive the cable.

Abstract: A conductive mounting structure for a lighting lamp. The lighting lamp comprises a first assembly (1) connected to a power supply and a second assembly (2) having a light source; the first assembly (1) comprises a first mounting member (11), and the second assembly (2) comprises a second mounting member (21). The first assembly (1) and the second assembly (2) are connected by using a connection structure. The connection structure comprises a contact (3), and a conductive component (4) conducted after being in contact with the contact (3), the contact (3) and the conductive component (4) are respectively provided on the first mounting member (11) and the second mounting member (21), and the contact (3) is in contact with the conductive component (4) after the first assembly (1) and the second assembly (2) are assembled and combined.

Abstract: Provided are methods and compositions comprising antibodies capable of specific binding to human CEACAM1 molecules, for treating and diagnosing cancer as well as assessing CEACAM1 expression in tumor infiltrating immune cells (TILs) in a biological sample obtained from a [cancer] subject.

Abstract: A processing system concurrency optimization system includes a processing system having first and second processing subsystems, a power system that is coupled to the first and second processing subsystems, a processing system concurrency optimization database, and a processing system concurrency optimization subsystem that is coupled to the power system and the processing system concurrency optimization database. The processing system concurrency optimization subsystem determines that a first workload has been provided for performance by the processing system, and identifies a first processing system concurrency optimization profile that is associated with the first workload in the processing system concurrency optimization database.

Abstract: A computing cooling system includes a chassis, heat dissipation device(s) in the chassis, a first fan system in the chassis configured to generate a first airflow that is directed past the heat dissipation device(s) and out of the chassis, and a second fan system in the chassis configured to generate a second airflow that is that is directed into the chassis. A board in the chassis includes a first board section located adjacent the first fan system, and a second board section located adjacent the second fan system and configured to receive the second airflow. The first board section includes first components that are thermally coupled to the heat dissipation device(s) and that are configured to operate in a first temperature range, and the second board section includes second components that are configured to operate in a second temperature range that is lower than the first temperature range.

Abstract: A line launcher includes a launcher body extending along a longitudinal axis between a rear end and a front end. The line launcher further includes a handle, a trigger, and a removable battery. The line launcher further includes a compressed gas charge assembly. The line launcher further includes an elongated barrel coupled to the body at the front end. The line launcher further includes a throwline assembly, the throwline assembly including a projectile and a throwline, the projectile insertable into and ejectable from the elongated barrel.

Abstract: A lightshow control system for generating a lightshow across a plurality of pixels or mobile devices comprises a controller configured to receive a lightshow operator's input and to generate a plurality of lightshow parameters. The system comprises a beacon transmitter in communication with the lightshow controller and configured to receive the lightshow parameters from the lightshow controller, encode the lightshow parameters on a beacon signal, and broadcast the beacon signal to the pixels, wherein each pixel is configured to receive and decode the beacon signal to perform one or more display actions. The decoded beacon signal includes reference timing information to facilitate synchronization of the pixels. The display actions may be based in part on the individual pixel location which is determined by the pixel based on TDOA multilateration and/or trilateration from distinct audio signals emitted by a plurality of speaker nodes.

Abstract: A computing device cooling system includes a chassis including chassis surface(s). The chassis houses component(s), chassis surface temperature sensor(s) configured to report a chassis surface temperature associated with the chassis surface(s), component temperature sensor(s) configured to report a component temperature associated with the component(s); a first fan system configured to generate a component cooling airflow that reduces the component temperature of the component(s), and a second fan system configured to generate a chassis surface cooling airflow that reduces the chassis surface temperature of the chassis surface(s). A fan control system is coupled to the chassis surface temperature sensor(s), the component temperature sensor(s), the first fan system, and the second fan system.

Abstract: An undercarriage unit is provided. The undercarriage unit comprises: a rotatable wheel; at least one electromagnet for releasably coupling the undercarriage unit to the aircraft; a switch for selectively activating and deactivating the at least one electromagnet; and a controller arranged to actuate the switch. An aircraft having the undercarriage unit is also provided.

Abstract: Fire protection systems and methods for ceiling-only high-piled storage protection. The systems include a plurality of fluid distribution devices disposed beneath a ceiling and above a high-piled storage commodity having a nominal storage height ranging from a nominal 20 ft. to a maximum nominal storage height of 55 ft. and means for quenching a fire in the storage commodity. The stored commodity to be protected may include ex posed expanded plastics. The fluid distribution devices include a frame body having an inlet, an outlet, a sealing assembly, and an electronically operated releasing mechanism supporting the sealing assembly in the outlet.

Abstract: The present disclosure provides a system and methods for transferring data across an interconnect. One method includes, at a request node, receiving, from a source high speed serial controller, a write request from a source, dividing the write request into sequences of smaller write requests each having a last identifier, and sending, to a home node, the sequences of smaller write requests; and, at the home node, sending, to a destination high speed serial controller, the sequences of smaller write requests for assembly into intermediate write requests that are transmitted to a destination. Each sequence of smaller write requests is assembled into an intermediate write request based on the last identifier.

Abstract: Fire protection systems and methods for ceiling-only high-piled storage protection. The systems include a plurality of fluid distribution devices disposed beneath a ceiling and above a high-piled storage commodity having a nominal storage height ranging from a nominal 20 ft. to a maximum nominal storage height of 55 ft. and means for quenching a fire in the storage commodity. The stored commodity to be protected may include exposed expanded plastics. The fluid distribution devices include a frame body having an inlet, an outlet, a sealing assembly, and an electronically operated releasing mechanism supporting the sealing assembly in the outlet.

Abstract: A data processing apparatus is provided that includes communication circuitry to transmit an interconnect message to a root port using a physical address mapped to the root port. Translation circuitry encapsulates, within the interconnect message to the root port, a Peripheral Component Interconnect Express (PCIe) message to a destination, the PCIe message having routing information encoded as a PCIe bus number associated with the destination.

Abstract: The present disclosure provides a system and methods for transferring data across an interconnect. One method includes, at a request node, receiving, from a source high speed serial controller, a write request from a source, dividing the write request into sequences of smaller write requests each having a last identifier, and sending, to a home node, the sequences of smaller write requests; and, at the home node, sending, to a destination high speed serial controller, the sequences of smaller write requests for assembly into intermediate write requests that are transmitted to a destination. Each sequence of smaller write requests is assembled into an intermediate write request based on the last identifier.

Abstract: Peripheral components, data processing systems and methods of operating such peripheral components and data processing systems are disclosed. The systems comprise an interconnect comprising a system cache, a peripheral component coupled to the interconnect, and a memory coupled to the interconnect. The peripheral component has a memory access request queue for queuing memory access requests in a receipt order. Memory access requests are issued to the interconnect in the receipt order. A memory read request is not issued to the interconnect until a completion response for all older memory write requests has been received from the interconnect. The peripheral component is responsive to receipt of a memory read request to issue a memory read prefetch request comprising a physical address to the interconnect and the interconnect is responsive to the memory read prefetch request to cause data associated with the physical address in the memory to be cached in the system cache.

Abstract: The present disclosure provides a method and system for generating a plurality of journeys for engaging a plurality of users in real-time. The system receives a first set of data associated with the plurality of users. In addition, the system fetches a second set of data associated with a plurality of past events on a plurality of platforms through one or more communication devices. Further, the system obtains a third set of data associated with a plurality of live events. Furthermore, the system analyzes the first set of data, the second set of data and the third set of data using one or more machine learning algorithms. Moreover, the system generates the plurality of journeys for engaging the plurality of users through a plurality of channels. Also, the system creates one or more goals for each of the plurality of journeys of the plurality of platforms.

Abstract: A data processing apparatus is provided that includes communication circuitry to transmit an interconnect message to a root port using a physical address mapped to the root port. Translation circuitry encapsulates, within the interconnect message to the root port, a Peripheral Component Interconnect Express (PCIe) message to a destination, the PCIe message having routing information encoded as a PCIe bus number associated with the destination.

Abstract: The present disclosure provides a computer-implemented method and system for assessing an effectiveness of one or more marketing campaigns using RFM matrix in real-time. The computer-implemented method and system corresponds to a marketing campaign evaluation system. The marketing campaign evaluation system receives a first set of data. The marketing campaign evaluation system fetches a second set of data. The marketing campaign evaluation system obtains a third set of data. The marketing campaign evaluation system analyzes the first set of data, the second set of data and the third set of data. The marketing campaign evaluation system enables segmentation of a plurality of users in one or more segments. The marketing campaign evaluation system initiates the one or more marketing campaigns through a RFM grid. The marketing campaign evaluation system creates a transition representation. The marketing campaign evaluation system evaluates the effectiveness of each of the one or more marketing campaigns.