Patents by Inventor Jacob Klein

Jacob Klein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240165027
    Abstract: Formulations (e.g., solutions) comprising one or more water-soluble polymer(s), liposomes, and an aqueous carrier, are provided. The provided solutions are useful for rinsing, and/or immersing therein, a contact lens and/or in the treatment of ocular discomfort, for example, an ocular discomfort associated with a contact lens. Also provided are kits comprising the solution and a contact lens; articles-of-manufacturing comprising the solution and configured for dispending the solution; and methods utilizing the solution.
    Type: Application
    Filed: January 29, 2024
    Publication date: May 23, 2024
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Jacob KLEIN, Ronit GOLDBERG, Jasmine SEROR
  • Patent number: 11883533
    Abstract: Formulations (e.g., solutions) comprising one or more water-soluble polymer(s), liposomes, and an aqueous carrier, are provided. The provided solutions are useful for rinsing, and/or immersing therein, a contact lens and/or in the treatment of ocular discomfort, for example, an ocular discomfort associated with a contact lens. Also provided are kits comprising the solution and a contact lens; articles-of-manufacturing comprising the solution and configured for dispending the solution; and methods utilizing the solution.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: January 30, 2024
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Jacob Klein, Ronit Goldberg, Jasmine Seror
  • Publication number: 20230394376
    Abstract: One embodiment of a method for automated decision making includes receiving a first set of features associated with a decision in a workflow, generating, using a trained causal inference machine learning model that predicts one or more effects of one or more actions on an outcome, a first action to perform in the workflow based on the first set of features, and transmitting one or more messages to one or more computing devices based on the first action.
    Type: Application
    Filed: May 31, 2023
    Publication date: December 7, 2023
    Inventors: Naama Parush Shear YASHUV, Ohad LEVINKRON-FISCH, Jacob KLEIN, Gerben OOSTRA
  • Publication number: 20230301915
    Abstract: A liposome for use in delivering a therapeutically active agent to a subject in need thereof is disclosed herein. The liposome comprises: a) at least one bilayer-forming lipid; b) a polymeric compound having the general formula I: wherein m, n, L, X, Y, and Z are as defined herein; and c) a therapeutically active agent, incorporated in the liposome and/or on a surface of the liposome.
    Type: Application
    Filed: May 29, 2023
    Publication date: September 28, 2023
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Jacob KLEIN, Ronit GOLDBERG, Weifeng LIN
  • Patent number: 11684578
    Abstract: A liposome for use in delivering a therapeutically active agent to a subject in need thereof is disclosed herein. The liposome comprises: a) at least one bilayer-forming lipid; b) a polymeric compound having the general formula I: wherein m, n, L, X, Y, and Z are as defined herein; and c) a therapeutically active agent, incorporated in the liposome and/or on a surface of the liposome.
    Type: Grant
    Filed: February 16, 2018
    Date of Patent: June 27, 2023
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Jacob Klein, Ronit Goldberg, Weifeng Lin
  • Publication number: 20230151129
    Abstract: A polymeric compound is disclosed herein, having the general formula I: wherein m, n, X, Y, Z and L are as defined herein. Further disclosed herein are lipid bilayers comprising at least one bilayer-forming lipid and the aforementioned polymeric compound, and liposomes comprising such a bilayer, as well as methods, uses and compositions utilizing such bilayers and/or liposomes for reducing a friction coefficient of a surface and/or for inhibiting biofilm formation.
    Type: Application
    Filed: July 25, 2022
    Publication date: May 18, 2023
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Jacob KLEIN, Weifeng LIN, Ronit GOLDBERG
  • Patent number: 11633358
    Abstract: A method of reducing a friction coefficient of a surface is disclosed herein, comprising attaching a water-soluble polymer to the surface, and contacting the water-soluble polymer with liposomes, thereby coating the surface with an amphiphilic lipid. Further disclosed herein are solutions comprising a water-soluble polymer attachable to the surface, liposomes, and an aqueous carrier, for reducing a friction coefficient of a surface, and methods utilizing same. Articles of manufacture comprising a substrate coated by a water-soluble polymer which is coated by an amphiphilic lipid are also described, as are uses and methods for treating a synovial joint disorder associated with increased articular friction.
    Type: Grant
    Filed: March 3, 2021
    Date of Patent: April 25, 2023
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Jacob Klein, Ronit Goldberg, Jasmine Seror, Weifeng Lin, Reut Mashiach
  • Publication number: 20230080018
    Abstract: The invention provides a method for lubricating one or more surfaces, comprising applying gel-phase liposomes onto said one or more surfaces, wherein the temperature of said surface(s) at the time of lubrication is below the phase transition temperature Tm of said liposomes. The method can be used for lubricating non-biological surfaces, and also for lubricating the surfaces of a biological tissue in a mammalian subject, e.g., for treating joint dysfunction.
    Type: Application
    Filed: November 10, 2022
    Publication date: March 16, 2023
    Applicants: YEDA RESEARCH AND DEVELOPMENT CO., LTD., YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LT
    Inventors: Jacob KLEIN et al., Ronit Goldberg, Yechezkel Barenholtz, Avi Schroeder
  • Patent number: 11541008
    Abstract: The invention provides a method for lubricating one or more surfaces, comprising applying gel-phase liposomes onto said one or more surfaces, wherein the temperature of said surface(s) at the time of lubrication is below the phase transition temperature Tm of said liposomes. The method can be used for lubricating non-biological surfaces, and also for lubricating the surfaces of a biological tissue in a mammalian subject, e.g., for treating joint dysfunction.
    Type: Grant
    Filed: March 5, 2020
    Date of Patent: January 3, 2023
    Assignees: YEDA RESEARCH AND DEVELOPMENT CO., LTD., YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD.
    Inventors: Jacob Klein, Ronit Goldberg, Yechezkel Barenholtz, Avi Schroeder
  • Patent number: 11396563
    Abstract: A polymeric compound is disclosed herein, having the general formula I: wherein m, n, X, Y, Z and L are as defined herein. Further disclosed herein are lipid bilayers comprising at least one bilayer-forming lipid and the aforementioned polymeric compound, and liposomes comprising such a bilayer, as well as methods, uses and compositions utilizing such bilayers and/or liposomes for reducing a friction coefficient of a surface and/or for inhibiting biofilm formation.
    Type: Grant
    Filed: July 2, 2020
    Date of Patent: July 26, 2022
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Jacob Klein, Weifeng Lin, Ronit Goldberg
  • Publication number: 20210378960
    Abstract: Formulations (e.g., solutions) comprising one or more water-soluble polymer(s), liposomes, and an aqueous carrier, are provided. The provided solutions are useful for rinsing, and/or immersing therein, a contact lens and/or in the treatment of ocular discomfort, for example, an ocular discomfort associated with a contact lens. Also provided are kits comprising the solution and a contact lens; articles-of-manufacturing comprising the solution and configured for dispending the solution; and methods utilizing the solution.
    Type: Application
    Filed: August 19, 2021
    Publication date: December 9, 2021
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Jacob KLEIN, Ronit GOLDBERG, Jasmine SEROR
  • Publication number: 20210186876
    Abstract: A method of reducing a friction coefficient of a surface is disclosed herein, comprising attaching a water-soluble polymer to the surface, and contacting the water-soluble polymer with liposomes, thereby coating the surface with an amphiphilic lipid. Further disclosed herein are solutions comprising a water-soluble polymer attachable to the surface, liposomes, and an aqueous carrier, for reducing a friction coefficient of a surface, and methods utilizing same. Articles of manufacture comprising a substrate coated by a water-soluble polymer which is coated by an amphiphilic lipid are also described, as are uses and methods for treating a synovial joint disorder associated with increased articular friction.
    Type: Application
    Filed: March 3, 2021
    Publication date: June 24, 2021
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Jacob KLEIN, Ronit GOLDBERG, Jasmine SEROR, Weifeng LIN, Reut MASHIACH
  • Patent number: 10940111
    Abstract: A method of reducing a friction coefficient of a surface is disclosed herein, comprising attaching a water-soluble polymer to the surface, and contacting the water-soluble polymer with liposomes, thereby coating the surface with an amphiphilic lipid. Further disclosed herein are solutions comprising a water-soluble polymer attachable to the surface, liposomes, and an aqueous carrier, for reducing a friction coefficient of a surface, and methods utilizing same. Articles of manufacture comprising a substrate coated by a water-soluble polymer which is coated by an amphiphilic lipid are also described, as are uses and methods for treating a synovial joint disorder associated with increased articular friction.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: March 9, 2021
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Jacob Klein, Ronit Goldberg, Jasmine Seror, Weifeng Lin, Reut Mashiach
  • Publication number: 20200338001
    Abstract: The invention provides a method for lubricating one or more surfaces, comprising applying gel-phase liposomes onto said one or more surfaces, wherein the temperature of said surface(s) at the time of lubrication is below the phase transition temperature Tm of said liposomes. The method can be used for lubricating non-biological surfaces, and also for lubricating the surfaces of a biological tissue in a mammalian subject, e.g., for treating joint dysfunction.
    Type: Application
    Filed: March 5, 2020
    Publication date: October 29, 2020
    Applicants: YEDA RESEARCH AND DEVELOPMENT CO., LTD., YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM,
    Inventors: Jacob Klein, Ronit Goldberg, Yechezkel Barenholtz, Avi Schroeder
  • Publication number: 20200332033
    Abstract: A polymeric compound is disclosed herein, having the general formula I: wherein m, n, X, Y, Z and L are as defined herein. Further disclosed herein are lipid bilayers comprising at least one bilayer-forming lipid and the aforementioned polymeric compound, and liposomes comprising such a bilayer, as well as methods, uses and compositions utilizing such bilayers and/or liposomes for reducing a friction coefficient of a surface and/or for inhibiting biofilm formation.
    Type: Application
    Filed: July 2, 2020
    Publication date: October 22, 2020
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Jacob KLEIN, Weifeng LIN, Ronit GOLDBERG
  • Patent number: 10799619
    Abstract: Hydrogels and composite material containing hydrogels and liposomes dispersed therein, which exhibit a reduced friction coefficient compared to neat hydrogels or composites containing hydrogels, processes for preparing the same, and methods for using the same are disclosed.
    Type: Grant
    Filed: April 18, 2019
    Date of Patent: October 13, 2020
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Jacob Klein, Ronit Goldberg, Noa Iuster, Raya Sorkin
  • Patent number: 10730976
    Abstract: A polymeric compound is disclosed herein, having the general formula I: wherein m, n, X, Y, Z and L are as defined herein. Further disclosed herein are lipid bilayers comprising at least one bilayer-forming lipid and the aforementioned polymeric compound, and liposomes comprising such a bilayer, as well as methods, uses and compositions utilizing such bilayers and/or liposomes for reducing a friction coefficient of a surface and/or for inhibiting biofilm formation.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: August 4, 2020
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Jacob Klein, Weifeng Lin, Ronit Goldberg
  • Publication number: 20190374466
    Abstract: A liposome for use in delivering a therapeutically active agent to a subject in need thereof is disclosed herein. The liposome comprises: a) at least one bilayer-forming lipid; b) a polymeric compound having the general formula I: wherein m, n, L, X, Y, and Z are as defined herein; and c) a therapeutically active agent, incorporated in the liposome and/or on a surface of the liposome.
    Type: Application
    Filed: February 16, 2018
    Publication date: December 12, 2019
    Applicant: Yeda Research and Development Co., Ltd.
    Inventors: Jacob KLEIN, Ronit GOLDBERG, Weifeng LIN
  • Publication number: 20190240378
    Abstract: Hydrogels and composite material containing hydrogels and liposomes dispersed therein, which exhibit a reduced friction coefficient compared to neat hydrogels or composites containing hydrogels, processes for preparing the same, and methods for using the same are disclosed.
    Type: Application
    Filed: April 18, 2019
    Publication date: August 8, 2019
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Jacob KLEIN, Ronit GOLDBERG, Noa IUSTER, Raya SORKIN
  • Patent number: 10323866
    Abstract: A heat pump system includes a shared motor having a common shaft; a thermoelectric generator conductively coupled to the shared motor, the thermoelectric generator is configured to provide electricity to the shared motor; a high-temperature compressor rotatably attached to the common shaft, the high-temperature compressor is configured to rotate the shared motor via the shared shaft and configure to channel heated fluid to the thermoelectric generator; a low-temperature compressor rotatably attached to the common shaft, the low-temperature compressor is configured to rotate the shared motor via the shared shaft and configure to channel cooled fluid to the thermoelectric generator; a first evaporation core in fluid communication with the thermoelectric generator; and a second evaporation core in fluid communication with the first evaporation core and in fluid communication with the high-temperature compressor.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: June 18, 2019
    Inventor: Jacob Klein