Patents by Inventor Jacob Koopman
Jacob Koopman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240115773Abstract: The present invention relates to a composition comprising fibrinogen for increasing the sensitivity of microorganisms for an antimicrobial compound. The invention may be used to alleviate the problem of antimicrobial resistance of microbial biofilms or aggregates, for example of microbial biofilms on medical devices, in particular indwelling devices, or in wound beds. The device or wound bed may be (pre-)coated with fibrinogen to increase antimicrobial susceptibility. The antimicrobial may be supplied separately from or together with the fibrinogen.Type: ApplicationFiled: October 23, 2020Publication date: April 11, 2024Applicant: FIBRIANT B.V.Inventors: Jacob KOOPMAN, Miranda WEGGEMAN, Joseph GRIMBERGEN
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Patent number: 11667694Abstract: The present invention relates to compositions comprising fibrinogen gamma prime variants for use in the treatment or prevention of an infection and methods of administering the composition. The fibrinogen gamma prime variants in the composition comprise at least one fibrinogen gamma prime polypeptide chain. The compositions for use according to the invention may also comprise other fibrinogen variants. Compositions comprising fibrinogen gamma prime variants according to the invention improve survival time after infection up to more than 200 percent compared to WT fibrinogen. They may be used both therapeutically and prophylactically.Type: GrantFiled: March 25, 2021Date of Patent: June 6, 2023Assignee: FIBRIANT B.V.Inventors: Miranda Weggeman, Joseph Grimbergen, Jacob Koopman
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Publication number: 20210347853Abstract: The present invention relates to compositions comprising fibrinogen gamma prime variants for use in the treatment or prevention of an infection and methods of administering the composition. The fibrinogen gamma prime variants in the composition comprise at least one fibrinogen gamma prime polypeptide chain. The compositions for use according to the invention may also comprise other fibrinogen variants. Compositions comprising fibrinogen gamma prime variants according to the invention improve survival time after infection up to more than 200 percent compared to WT fibrinogen. They may be used both therapeutically and prophylactically.Type: ApplicationFiled: March 25, 2021Publication date: November 11, 2021Inventors: Miranda Weggeman, Joseph Grimbergen, Jacob Koopman
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Publication number: 20200199198Abstract: The present invention relates to compositions comprising fibrinogen gamma prime variants for use in the treatment or prevention of an infection. The fibrinogen gamma prime variants in the composition comprise at least one fibrinogen gamma prime polypeptide chain. The compositions for use according to the invention may also comprise other fibrinogen variants. Compositions comprising fibrinogen gamma prime variants according to the invention improve survival time after infection up to more than 200 percent compared to WT fibrinogen. They may be used both therapeutically and prophylactically.Type: ApplicationFiled: December 16, 2019Publication date: June 25, 2020Inventors: Miranda Weggeman, Joseph Grimbergen, Jacob Koopman
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Patent number: 10562956Abstract: The present invention relates to nucleotide sequences encoding a fibrinogen alpha, beta or gamma chain. The sequences are optimized for expression in a eukaryotic cell culture system. Such optimized nucleotide sequences allow for the efficient expression of recombinant fibrinogen and variants thereof in intact form in a eukaryotic cell culture system.Type: GrantFiled: October 24, 2016Date of Patent: February 18, 2020Assignee: Mallinckrodt Pharma IP Trading D.A.C.Inventors: Abraham Bout, Joseph Grimbergen, Jacob Koopman
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Patent number: 10004787Abstract: The present invention relates to fibrinogen preparations enriched in ?-extended fibrinogen. Compositions comprising such preparations show improved clotting properties compared to preparations based on HMW Fib which typically contain no or only low amounts of ?-extended fibrinogen. In particular, clot formation time and the clot strength of a clot made by ?-extended fibrinogen are improved. In addition, plasmin-mediated degradation of ?-extended fibrinogen is reduced as compared to plasma derived fibrinogen.Type: GrantFiled: June 5, 2017Date of Patent: June 26, 2018Assignee: Mallinckrodt Pharma IP Trading D.A.C.Inventors: Joseph Grimbergen, Jacob Koopman, Abraham Bout
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Publication number: 20170266262Abstract: The present invention relates to fibrinogen preparations enriched in ?-extended fibrinogen. Compositions comprising such preparations show improved clotting properties compared to preparations based on HMW Fib which typically contain no or only low amounts of ?-extended fibrinogen. In particular, clot formation time and the clot strength of a clot made by ?-extended fibrinogen are improved. In addition, plasmin-mediated degradation of ?-extended fibrinogen is reduced as compared to plasma derived fibrinogen.Type: ApplicationFiled: June 5, 2017Publication date: September 21, 2017Inventors: Joseph Grimbergen, Jacob Koopman, Abraham Bout
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Patent number: 9694054Abstract: The present invention relates to fibrinogen preparations enriched in ?-extended fibrinogen. Compositions comprising such preparations show improved clotting properties compared to preparations based on HMW Fib which typically contain no or only low amounts of ?-extended fibrinogen. In particular, clot formation time and the clot strength of a clot made by ?-extended fibrinogen are improved. In addition, plasmin-mediated degradation of ?-extended fibrinogen is reduced as compared to plasma derived fibrinogen.Type: GrantFiled: October 7, 2015Date of Patent: July 4, 2017Assignee: Mallinckrodt Oharma IP Trading D.A.C.Inventors: Joseph Grimbergen, Jacob Koopman, Abraham Bout
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Publication number: 20170037108Abstract: The present invention relates to nucleotide sequences encoding a fibrinogen alpha, beta or gamma chain. The sequences are optimized for expression in a eukaryotic cell culture system. Such optimized nucleotide sequences allow for the efficient expression of recombinant fibrinogen and variants thereof in intact form in a eukaryotic cell culture system.Type: ApplicationFiled: October 24, 2016Publication date: February 9, 2017Inventors: Abraham Bout, Joseph Grimbergen, Jacob Koopman
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Publication number: 20160158323Abstract: The present invention relates to fibrinogen preparations enriched in ?-extended fibrinogen. Compositions comprising such preparations show improved clotting properties compared to preparations based on HMW Fib which typically contain no or only low amounts of ?-extended fibrinogen. In particular, clot formation time and the clot strength of a clot made by ?-extended fibrinogen are improved. In addition, plasmin-mediated degradation of ?-extended fibrinogen is reduced as compared to plasma derived fibrinogen.Type: ApplicationFiled: October 7, 2015Publication date: June 9, 2016Inventors: Joseph Grimbergen, Jacob Koopman, Abraham Bout
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Patent number: 9119897Abstract: A fibrin sealant comprises a mixture of first microparticles that comprise fibrinogen, second microparticles that comprise thrombin, and additive material. The additive material may be particulate, and may be, for instance, a biocompatible, water-absorbent, material, a biocompatible, water-swellable material, a biocompatible, water-insoluble material, a polysaccharide or silica.Type: GrantFiled: May 28, 2010Date of Patent: September 1, 2015Assignee: PROFIBRIX B.V.Inventors: Glen Patrick Martyn, Jacob Koopman
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Patent number: 9089584Abstract: Dry powder compositions are useful in the treatment or prevention of tissue adhesions during or after surgery or during wound therapy. The dry powder compositions may contain trehalose. The dry powder compositions may be fibrin sealant compositions comprising fibrinogen and/or thrombin.Type: GrantFiled: May 28, 2010Date of Patent: July 28, 2015Assignee: PROFIBRIX B.V.Inventor: Jacob Koopman
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Patent number: 8846105Abstract: The present invention relates to a dry powder fibrin sealant which comprises a mixture of fibrinogen and thrombin for use in surgery, trauma and other wounds or injuries. It further relates to novel formulations comprising said dry powder fibrin sealant for use in the treatment of wounds or for surgical intervention or as a topical hemostat.Type: GrantFiled: January 7, 2011Date of Patent: September 30, 2014Assignee: Profibrix, B.V.Inventors: Jacob Koopman, Glen Martyn
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Publication number: 20130011382Abstract: The present invention relates to fibrinogen preparations enriched in ?-extended fibrinogen. Compositions comprising such preparations show improved clotting properties compared to preparations based on HMW Fib which typically contain no or only low amounts of ?-extended fibrinogen. In particular, clot formation time and the clot strength of a clot made by ?-extended fibrinogen are improved. In addition, plasmin-mediated degradation of ?-extended fibrinogen is reduced as compared to plasma derived fibrinogen.Type: ApplicationFiled: January 7, 2011Publication date: January 10, 2013Applicant: PROFIBRIX BVInventors: Joseph Grimbergen, Jacob Koopman, Abraham Bout
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Publication number: 20120315305Abstract: The present invention relates to a dry powder fibrin sealant which comprises a mixture of fibrinogen and thrombin for use in surgery, trauma and other wounds or injuries. It further relates to novel formulations comprising said dry powder fibrin sealant for use in the treatment of wounds or for surgical intervention or as a topical hemostat.Type: ApplicationFiled: January 7, 2011Publication date: December 13, 2012Applicant: PROFIBRIX BVInventors: Jacob Koopman, Glen Martyn
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Publication number: 20120070477Abstract: A fibrin sealant comprises a mixture of first microparticles that comprise fibrinogen, second microparticles that comprise thrombin, and additive material. The additive material may be particulate, and may be, for instance, a biocompatible, water-absorbent, material, a biocompatible, water-swellable material, a biocompatible, water-insoluble material, a polysaccharide or silica.Type: ApplicationFiled: May 28, 2010Publication date: March 22, 2012Applicant: PROFIBRIX B.V.Inventors: Glen Patrick Martyn, Jacob Koopman
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Publication number: 20120064165Abstract: Dry powder compositions are useful in the treatment or prevention of tissue adhesions during or after surgery or during wound therapy. The dry powder compositions may contain trehalose. The dry powder compositions may be fibrin sealant compositions comprising fibrinogen and/or thrombin.Type: ApplicationFiled: May 28, 2010Publication date: March 15, 2012Applicant: PROFIBRIX B.V.Inventor: Jacob Koopman