Patents by Inventor Jacob Koppel Freudenthal
Jacob Koppel Freudenthal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7320777Abstract: A device for handling PCR microcards, each having an array of sample chambers closed by a transparent material on one side thereof, in relation to a PCR instrument, the device including a carrier having an apertured region with an array of holes corresponding in number and relative location with the array of sample chambers in each of the microcards, and a provision for retaining a microcard on the carrier so that the transparent material faces the apertured region with the reagent sample chambers aligned, respectively, with the holes in the apertured region, and so that the side of the microcard opposite the transparent material is unobstructed at least throughout the array of sample chambers. The device cooperates with the PCR instrument to ensure accurate positioning of the carrier and the microcard retained thereon for real time PCR processing.Type: GrantFiled: November 22, 2002Date of Patent: January 22, 2008Assignee: Applera CorporationInventors: Gary L. Bordenkircher, Gary Lim, Jacob Koppel Freudenthal
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Patent number: 6942837Abstract: A system for filling a substrate having at least one chamber with a liquid sample is provided. The system in one embodiment includes a substrate defining a network of passageways including at least one chamber for the liquid sample, and an adapter. The adapter includes a fill reservoir for the liquid sample, a vacuum port for attachment to a vacuum source, and at least two channels. One channel allows a vacuum to be imparted to the network, and the other channel allows the liquid sample to be introduced into the network. The system also includes a mechanism that sequentially closes and opens at least one of the channels so that a vacuum can first be introduced to the substrate and thereafter the liquid sample introduced to the substrate for permitting the vacuum to urge the liquid sample to flow from the fill reservoir into the substrate. An apparatus for positioning a substrate with a plurality of sample detection chambers in a detection unit is also provided.Type: GrantFiled: May 4, 2001Date of Patent: September 13, 2005Assignee: Applera CorporationInventors: Ward Kevin Frye, Jacob Koppel Freudenthal, Terri Christina Labelle, Eugene Young
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Publication number: 20030124714Abstract: A device for handling PCR microcards, each having an array of sample chambers closed by a transparent material on one side thereof, in relation to a PCR instrument, the device including a carrier having an apertured region with an array of holes corresponding in number and relative location with the array of sample chambers in each of the microcards, and a provision for retaining a microcard on the carrier so that the transparent material faces the apertured region with the reagent sample chambers aligned, respectively, with the holes in the apertured region, and so that the side of the microcard opposite the transparent material is unobstructed at least throughout the array of sample chambers. The device cooperates with the PCR instrument to ensure accurate positioning of the carrier and the microcard retained thereon for real time PCR processing.Type: ApplicationFiled: November 22, 2002Publication date: July 3, 2003Applicant: PE Corporation (NY)Inventors: Gary L. Bordenkircher, Gary Lim, Jacob Koppel Freudenthal
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Patent number: 6514750Abstract: A device for handling PCR microcards, each having an array of sample chambers closed by a transparent material on one side thereof, in relation to a PCR instrument, the device including a carrier having an apertured region with an array of holes corresponding in number and relative location with the array of sample chambers in each of the microcards, and a provision for retaining a microcard on the carrier so that the transparent material faces the apertured region with the reagent sample chambers aligned, respectively, with the holes in the apertured region, and so that the side of the microcard opposite the transparent material is unobstructed at least throughout the array of sample chambers. The device cooperates with the PCR instrument to ensure accurate positioning of the carrier and the microcard retained thereon for real time PCR processing.Type: GrantFiled: July 3, 2001Date of Patent: February 4, 2003Assignee: PE Corporation (NY)Inventors: Gary L. Bordenkircher, Gary Lim, Jacob Koppel Freudenthal
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Publication number: 20030008383Abstract: A device for handling PCR microcards, each having an array of sample chambers closed by a transparent material on one side thereof, in relation to a PCR instrument, the device including a carrier having an apertured region with an array of holes corresponding in number and relative location with the array of sample chambers in each of the microcards, and a provision for retaining a microcard on the carrier so that the transparent material faces the apertured region with the reagent sample chambers aligned, respectively, with the holes in the apertured region, and so that the side of the microcard opposite the transparent material is unobstructed at least throughout the array of sample chambers. The device cooperates with the PCR instrument to ensure accurate positioning of the carrier and the microcard retained thereon for real time PCR processing.Type: ApplicationFiled: July 3, 2001Publication date: January 9, 2003Inventors: Gary L. Bordenkircher, Gary Lim, Jacob Koppel Freudenthal
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Publication number: 20010029794Abstract: A system for filling a substrate having at least one chamber with a liquid sample is provided. The system in one embodiment includes a substrate defining a network of passageways including at least one chamber for the liquid sample, and an adapter. The adapter includes a fill reservoir for the liquid sample, a vacuum port for attachment to a vacuum source, and at least two channels. One channel allows a vacuum to be imparted to the network, and the other channel allows the liquid sample to be introduced into the network. The system also includes a mechanism that sequentially closes and opens at least one of the channels so that a vacuum can first be introduced to the substrate and thereafter the liquid sample introduced to the substrate for permitting the vacuum to urge the liquid sample to flow from the fill reservoir into the substrate. An apparatus for positioning a substrate with a plurality of sample detection chambers in a detection unit is also provided.Type: ApplicationFiled: May 4, 2001Publication date: October 18, 2001Applicant: Applera CorporationInventors: Ward Kevin Frye, Jacob Koppel Freudenthal, Terri Christina Labelle, Eugene Young
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Patent number: 6272939Abstract: A system for filling a substrate having at least one chamber with a liquid sample is provided. The system in one embodiment includes a substrate defining a network of passageways including at least one chamber for the liquid sample, and an adapter. The adapter includes a fill reservoir for the liquid sample, a vacuum port for attachment to a vacuum source, and at least two channels. One channel allows a vacuum to be imparted to the network, and the other channel allows the liquid sample to be introduced into the network. The system also includes a mechanism that sequentially closes and opens at least one of the channels so that a vacuum can first be introduced to the substrate and thereafter the liquid sample introduced to the substrate for permitting the vacuum to urge the liquid sample to flow from the fill reservoir into the substrate. An apparatus for positioning a substrate with a plurality of sample detection chambers in a detection unit is also provided.Type: GrantFiled: April 13, 2000Date of Patent: August 14, 2001Assignee: Applera CorporationInventors: Ward Kevin Frye, Jacob Koppel Freudenthal, Terri Christina LaBelle, Eugene Young