Patents by Inventor Jacob L. SWETT
Jacob L. SWETT has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210325379Abstract: The present disclosure provides devices, systems, and methods related to single molecule detection. In particular, the present disclosure provides devices and methods for sequence-specific detection of a nucleic acid target using current fluctuations as a readout for protein binding to the nucleic acid target. As described herein, certain aspects of the bioelectronic devices and method can be used to detect and identify any nucleic acid target for the purpose of diagnosis and/or treatment.Type: ApplicationFiled: April 16, 2021Publication date: October 21, 2021Inventors: Stuart Lindsay, Karen Anderson, Mark Knappenberger, Sepideh Afsari Mamaghani, Jacob L. Swett
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Patent number: 10980919Abstract: Two-dimensional materials, particularly graphene-based materials, having a plurality of apertures thereon can be formed into enclosures for various substances and introduced to an environment, particularly a biological environment (in vivo or in vitro). One or more selected substances can be released into the environment, one or more selected substances from the environment can enter the enclosure, one or more selected substances from the environment can be prevented from entering the enclosure, one or more selected substances can be retained within the enclosure, or combinations thereof. The enclosure can for example allow a sense-response paradigm to be realized. The enclosure can for example provide immunoisolation for materials, such as living cells, retained therein.Type: GrantFiled: April 14, 2016Date of Patent: April 20, 2021Assignee: Lockheed Martin CorporationInventors: Sarah M. Simon, Jacob L. Swett
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Patent number: 10865112Abstract: Modified substrates are provided having nano- or microscale wells, tracks, channels, pores or perforations. Also provided are methods of making the same.Type: GrantFiled: December 13, 2018Date of Patent: December 15, 2020Assignee: Lockheed Martin CorporationInventors: Scott E. Heise, Han Liu, Jacob L. Swett, Michael J. Hiltabidle
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Patent number: 10696554Abstract: Multi-layer sheets of graphene-based material having a plurality of pores extending therethrough are described herein. Methods for making the sheets are also provided and include exposing a graphene-based material comprising multilayer graphene having from 2 to 10 layers of graphene to a particle beam comprising nanoparticles, the nanoparticles having an energy of at least 2 keV per nanoparticle.Type: GrantFiled: April 14, 2016Date of Patent: June 30, 2020Assignee: Lockheed Martin CorporationInventors: Peter V. Bedworth, Jacob L. Swett
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Publication number: 20200189914Abstract: Modified substrates are provided having nano- or microscale wells, tracks, channels, pores or perforations. Also provided are methods of making the same.Type: ApplicationFiled: December 13, 2018Publication date: June 18, 2020Applicant: LOCKHEED MARTIN CORPORATIONInventors: Scott E. Heise, Han Liu, Jacob L. Swett, Michael J. Hiltabidle
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Patent number: 10653824Abstract: Various systems and methods relating to two-dimensional materials such as graphene. A membrane include a cross-linked graphene platelet polymer that includes a plurality of cross-linked graphene platelets. The cross-linked graphene platelets include a graphene portion and a cross-linking portion. The cross-linking portion contains a 4 to 10 atom link. The cross-linked graphene platelet polymer is produced by reaction of an epoxide functionalized graphene platelet and a (meth)acrylate or (meth)acrylamide functionalized cross-linker.Type: GrantFiled: April 14, 2016Date of Patent: May 19, 2020Assignee: Lockheed Martin CorporationInventors: Peter V. Bedworth, Steven Edward Bullock, Sarah M. Simon, Steven W. Sinton, John B. Stetson, Jr., Jacob L. Swett, Scott E. Heise
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Patent number: 10418143Abstract: Sheets of graphene-based material comprising single layer graphene and suitable for formation of a plurality of perforations in the single layer graphene are provided. In an aspect, the sheets of graphene-based material are formed by chemical vapor deposition followed by one or more conditioning steps. In a further aspect, the sheets of graphene-based material include non-graphenic carbon-based material and may be characterized the amount, mobility and/or volatility of the non-graphenic carbon-based material.Type: GrantFiled: April 14, 2016Date of Patent: September 17, 2019Assignee: Lockheed Martin CorporationInventors: Jacob L. Swett, Peter V. Bedworth, Scott E. Heise, Steven W. Sinton, Sarah M Simon
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Patent number: 10203295Abstract: Production of perforated two-dimensional materials with holes of a desired size range, a narrow size distribution, and a high and uniform density remains a challenge, at least partially, due to physical and chemical inconsistencies from sheet-to-sheet of the two-dimensional material and surface contamination. This disclosure describes methods for monitoring and adjusting perforation or healing conditions in real-time to address inter- and intra-sheet variability. In situ or substantially simultaneous feedback on defect production or healing may be provided either locally or globally on a graphene or other two-dimensional sheet. The feedback data can be used to adjust perforation or healing parameters, such as the total dose or efficacy of the perforating radiation, to achieve the desired defect state.Type: GrantFiled: April 14, 2016Date of Patent: February 12, 2019Assignee: Lockheed Martin CorporationInventors: Jacob L. Swett, Peter V. Bedworth
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Patent number: 10017852Abstract: A method for transferring a graphene sheet from a copper substrate to a functional substrate includes forming the graphene sheet on the copper substrate using chemical vapor deposition, and irradiating the graphene sheet disposed on the copper substrate with a plurality of xenon ions using broad beam irradiation to form a prepared graphene sheet. The prepared graphene sheet is resistant to forming unintentional defects induced during transfer of the prepared graphene sheet to the functional substrate. The method further includes removing the copper substrate from the prepared graphene sheet using an etchant bath, floating the prepared graphene sheet in a floating bath, submerging the functional substrate in the floating bath, and decreasing a fluid level of the floating bath to lower the prepared graphene sheet onto the functional substrate.Type: GrantFiled: April 14, 2016Date of Patent: July 10, 2018Assignee: Lockheed Martin CorporationInventors: Scott E. Heise, Peter V. Bedworth, Jacob L. Swett, Steven W. Sinton
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Patent number: 10005038Abstract: Perforated graphene and other perforated two-dimensional materials can be used in hemodialysis membranes and blood filtration membranes for selective removal of components from blood in vivo and ex vivo. The membranes are useful in hemodialysis and hemofiltration techniques to provide improved patient care. Hemodialysis systems can include a hemodialysis membrane formed from perforated graphene or another perforated two-dimensional material disposed upon a porous support structure. Hemofiltration systems can include one or more and preferably two or more blood filtration membrane formed from perforated graphene or another perforated two-dimensional material disposed upon a porous support structure. Methods for performing hemodialysis can involve exposing blood from a patient to a hemodialysis membrane formed from a perforated two-dimensional material. Ex vivo dialysis techniques can be performed similarly.Type: GrantFiled: September 2, 2015Date of Patent: June 26, 2018Assignee: Lockheed Martin CorporationInventors: John B. Stetson, Jr., Sarah Simon, Jacob L. Swett
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Publication number: 20170296706Abstract: Two-dimensional materials, particularly graphene-based materials, having a plurality of apertures thereon can be formed into enclosures for various substances and introduced to an environment, particularly a biological environment (in vivo or in vitro). One or more selected substances can be released into the environment, one or more selected substances from the environment can enter the enclosure, one or more selected substances from the environment can be prevented from entering the enclosure, one or more selected substances can be retained within the enclosure, or combinations thereof. The enclosure can for example allow a sense-response paradigm to be realized. The enclosure can for example provide immunoisolation for materials, such as living cells, retained therein.Type: ApplicationFiled: April 14, 2016Publication date: October 19, 2017Applicant: Lockheed Martin CorporationInventors: Sarah M. SIMON, Jacob L. SWETT
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Publication number: 20170299537Abstract: Production of perforated two-dimensional materials with holes of a desired size range, a narrow size distribution, and a high and uniform density remains a challenge, at least partially, due to physical and chemical inconsistencies from sheet-to-sheet of the two-dimensional material and surface contamination. This disclosure describes methods for monitoring and adjusting perforation or healing conditions in real-time to address inter- and intra-sheet variability. In situ or substantially simultaneous feedback on defect production or healing may be provided either locally or globally on a graphene or other two-dimensional sheet. The feedback data can be used to adjust perforation or healing parameters, such as the total dose or efficacy of the perforating radiation, to achieve the desired defect state.Type: ApplicationFiled: April 14, 2016Publication date: October 19, 2017Applicant: Lockheed Martin CorporationInventors: Jacob L. Swett, Peter V. Bedworth
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Publication number: 20170298504Abstract: A method for transferring a graphene sheet from a copper substrate to a functional substrate includes forming the graphene sheet on the copper substrate using chemical vapor deposition, and irradiating the graphene sheet disposed on the copper substrate with a plurality of xenon ions using broad beam irradiation to form a prepared graphene sheet. The prepared graphene sheet is resistant to forming unintentional defects induced during transfer of the prepared graphene sheet to the functional substrate. The method further includes removing the copper substrate from the prepared graphene sheet using an etchant bath, floating the prepared graphene sheet in a floating bath, submerging the functional substrate in the floating bath, and decreasing a fluid level of the floating bath to lower the prepared graphene sheet onto the functional substrate.Type: ApplicationFiled: April 14, 2016Publication date: October 19, 2017Applicant: Lockheed Martin CorporationInventors: Scott E. Heise, Peter V. Bedworth, Jacob L. Swett, Steven W. Sinton
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Patent number: 9744617Abstract: Multi-layer sheets of graphene-based material having a plurality of pores extending therethrough are described herein. Methods for making the sheets include exposing a graphene-based material comprising multilayer graphene having from 5 to 20 layers of graphene to a particle beam having an ion energy of at least about 1500 eV to create damage tracks in the graphene sheets. The damage tracks in the graphene sheets are then exposed to a chemical etchant, such as an oxidant to define pores through the stacked graphene sheets. Production of the damage tracks and etching of the damage tracks can take place while the graphene is disposed on a substrate.Type: GrantFiled: August 5, 2015Date of Patent: August 29, 2017Assignee: LOCKHEED MARTIN CORPORATIONInventors: Peter V. Bedworth, Jacob L. Swett
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Patent number: 9649718Abstract: Multi-layer sheets of graphene-based material having a plurality of pores extending therethrough are described herein. Methods for making the sheets include exposing a graphene-based material comprising multilayer graphene having from 5 to 20 layers of graphene to a particle beam having an ion energy of at least about 1500 eV to create damage tracks in the graphene sheets. The damage tracks in the graphene sheets are then exposed to a chemical etchant, such as an oxidant to define pores through the stacked graphene sheets. Production of the damage tracks and etching of the damage tracks can take place while the graphene is disposed on a substrate.Type: GrantFiled: August 5, 2015Date of Patent: May 16, 2017Assignee: LOCKHEED MARTIN CORPORATIONInventors: Peter V. Bedworth, Jacob L. Swett
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Patent number: 9610546Abstract: Perforated graphene sheets can be used in forming separation membranes. Separation membranes of the present disclosure, which can be used in gas separation processes in some embodiments, can include one or more layers of perforated graphene and one or more layers of another membrane material. Methods for separating a gas mixture can include contacting a gas mixture with the separation membranes, and transiting one or more of the gases through the perforated graphene so as to affect separation.Type: GrantFiled: September 16, 2015Date of Patent: April 4, 2017Assignee: LOCKHEED MARTIN CORPORATIONInventors: Steven W. Sinton, Peter V. Bedworth, Padraig Moloney, Jacob L. Swett
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Publication number: 20170036916Abstract: Multi-layer sheets of graphene-based material having a plurality of pores extending therethrough are described herein. Methods for making the sheets are also provided and include exposing a graphene-based material comprising multilayer graphene having from 2 to 10 layers of graphene to a particle beam comprising nanoparticles, the nanoparticles having an energy of at least 2 keV per nanoparticle.Type: ApplicationFiled: April 14, 2016Publication date: February 9, 2017Applicant: Lockheed Martin CorporationInventors: Peter V. BEDWORTH, Jacob L. SWETT
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Publication number: 20170035943Abstract: Two-dimensional materials can be formed into enclosures for various substances and a substrate layer can be provided on an outside and/or on an inside of the enclosure, wherein the enclosure is not cytotoxic. The enclosures can be exposed to an environment, such as a biological environment (in vivo or in vitro), where the fibrous layer can promote vascular ingrowth. One or more substances within the enclosure can be released into the environment, one or more selected substances from the environment can enter the enclosure, one or more selected substances from the environment can be prevented from entering the enclosure, one or more selected substances can be retained within the enclosure, or combinations thereof. The enclosure can, for example, allow a sense-response paradigm to be realized. The enclosure can, for example, provide immunoisolation for materials, such as living cells, retained therein.Type: ApplicationFiled: April 14, 2016Publication date: February 9, 2017Applicant: Lockheed Martin CorporationInventors: Sarah M. SIMON, Jacob L. Swett, Peter V. Bedworth, Scott E. Heise
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Publication number: 20170040082Abstract: Sheets of graphene-based material comprising single layer graphene and suitable for formation of a plurality of perforations in the single layer graphene are provided. In an aspect, the sheets of graphene-based material are formed by chemical vapor deposition followed by one or more conditioning steps. In a further aspect, the sheets of graphene-based material include non-graphenic carbon-based material and may be characterized the amount, mobility and/or volatility of the non-graphenic carbon-based material.Type: ApplicationFiled: April 14, 2016Publication date: February 9, 2017Applicant: Lockheed Martin CorporationInventors: Jacob L. SWETT, Peter V. BEDWORTH, Scott E. HEISE, Steven W. SINTON, Sarah M. SIMON
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Publication number: 20170036911Abstract: Perforated sheets of graphene-based material having a plurality of perforations are provided. The perforated sheets may include perforated single layer graphene. The perforations may be located over greater than 10% of said area of said sheet of graphene-based material and the mean pore size of the perforations selected from the range of 0.3 nm to 1 ?m. Methods for making the perforated sheets are also provided.Type: ApplicationFiled: April 14, 2016Publication date: February 9, 2017Applicant: Lockheed Martin CorporationInventors: Jacob L. SWETT, Peter V. BEDWORTH, Scott E. HEISE, Steven W. SINTON, Sarah M. SIMON