Patents by Inventor Jacob LAYER

Jacob LAYER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cells, tissues, organs, and animals having one or more modified genes for enhanced xenograft survival and tolerance
    Patent number: 12637690
    Abstract: The present disclosure relates to cells, tissues, organs, and/or animals having one or more modified genes for enhanced xenograft survival and/or tolerance. In addition, the present disclosure relates to methods of making and using the cells, tissues, organs, and/or animals having one or more of the modified genes.
    Type: Grant
    Filed: July 15, 2025
    Date of Patent: May 26, 2026
    Assignee: eGenesis, Inc.
    Inventors: Jacob Layer, Wenning Qin, Yinan Kan, Juliet Crabtree, Michele Youd, David Heja, David Angeles Albores, Ranjith Anand, Paola Perrat, Russell Ernst, Violette Paragas
  • Cells, tissues, organs, and animals having one or more modified genes for enhanced xenograft survival and tolerance
    Patent number: 12630838
    Abstract: The present disclosure relates to cells, tissues, organs, and/or animals having one or more modified genes for enhanced xenograft survival and/or tolerance. In addition, the present disclosure relates to methods of making and using the cells, tissues, organs, and/or animals having one or more of the modified genes.
    Type: Grant
    Filed: June 1, 2023
    Date of Patent: May 19, 2026
    Assignee: eGenesis, Inc.
    Inventors: Jacob Layer, Wenning Qin, Yinan Kan, Juliet Crabtree, Michele Youd, David Heja, David Angeles Albores, Ranjith Anand, Paola Perrat, Russell Ernst, Violette Paragas
  • CELLS, TISSUES, ORGANS, AND ANIMALS HAVING ONE OR MORE MODIFIED GENES FOR ENHANCED XENOGRAFT SURVIVAL AND TOLERANCE
    Publication number: 20260098278
    Abstract: The present disclosure relates to cells, tissues, organs, and/or animals having one or more modified genes for enhanced xenograft survival and/or tolerance. In addition, the present disclosure relates to methods of making and using the cells, tissues, organs, and/or animals having one or more of the modified genes.
    Type: Application
    Filed: December 9, 2025
    Publication date: April 9, 2026
    Inventors: Jacob LAYER, Wenning QIN, Yinan KAN, Juliet CRABTREE, Michele YOUD, David HEJA, David ANGELES ALBORES, Ranjith ANAND, Paola PERRAT, Russell ERNST, Violette PARAGAS
  • ENGINEERED RETRONS AND METHODS OF USE
    Publication number: 20260062700
    Abstract: Disclosed are engineered retrons and methods of use such as to modify the genome of a host (e.g, mammalian) cell by delivering the engineered retron or the encoded ncRNA in vitro or in vivo to the host (e.g., mammalian) cell.
    Type: Application
    Filed: August 24, 2023
    Publication date: March 5, 2026
    Inventors: Alim LADHA, Vladimir PRESNYAK, Inna SHCHERBAKOVA, Brian GOODMAN, Mario Rodriguez MESTRE, Kyong-Rim KIEFFER-KWON, Socheata LY, Devin Scott QUINLAN, Muthusamy JAYARAMAN, Stephen SCULLY, Jacob LAYER, Abril Fleitas Beitans, Zhongxia YI
  • CELLS, TISSUES, ORGANS, AND ANIMALS HAVING ONE OR MORE MODIFIED GENES FOR ENHANCED XENOGRAFT SURVIVAL AND TOLERANCE
    Publication number: 20250346918
    Abstract: The present disclosure relates to cells, tissues, organs, and/or animals having one or more modified genes for enhanced xenograft survival and/or tolerance. In addition, the present disclosure relates to methods of making and using the cells, tissues, organs, and/or animals having one or more of the modified genes.
    Type: Application
    Filed: July 15, 2025
    Publication date: November 13, 2025
    Inventors: Jacob LAYER, Wenning QIN, Yinan KAN, Juliet CRABTREE, Michele YOUD, David HEJA, David ANGELES ALBORES, Ranjith ANAND, Paola PERRAT, Russell ERNST, Violette PARAGAS
  • CELLS, TISSUES, ORGANS, AND ANIMALS HAVING ONE OR MORE MODIFIED GENES FOR ENHANCED XENOGRAFT SURVIVAL AND TOLERANCE
    Publication number: 20240084322
    Abstract: The present disclosure relates to cells, tissues, organs, and/or animals having one or more modified genes for enhanced xenograft survival and/or tolerance. In addition, the present disclosure relates to methods of making and using the cells, tissues, organs, and/or animals having one or more of the modified genes.
    Type: Application
    Filed: June 1, 2023
    Publication date: March 14, 2024
    Inventors: Jacob LAYER, Wenning QIN, Yinan KAN, Juliet CRABTREE, Michele YOUD, David HEJA, David ANGELES ALBORES, Ranjith ANAND, Paola PERRAT, Russell ERNST, Violette PARAGAS