Abstract: Disclosed are specific binding molecules (e.g. antibodies) that are provided in a set of conjugates, where each conjugate comprises an antibody linked to an oligonucleotide (oligo), such as a DNA oligonucleotide. The antibodies in each set are to the same target antigen. One antibody is preferably immobilized so that it remains in the sample reaction after a wash step. One antibody is used for detection since it will remain in the sample after washing only if there is a specific antibody-target antigen. The oligos in a given set hybridize to each other when both antibodies bind to a target with immuno-specificity. However, if the binding is not immune specific, such as in the case of cross-reactivity, the oligos do not hybridize.

Abstract: Age and related conditions are assessed with a gene expression test that determines the expression levels of a panel of genetic markers. Each age signature contains expression information for genes in at least one functional group that is identified herein as having an expression pattern that correlates with physiological aging of a tissue or tissue of interest.

Abstract: Monodisperse high polymer compositions and related methods for reduction of polydispersity indices.