Patents by Inventor Jacob Marinus Jan Den Toonder
Jacob Marinus Jan Den Toonder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240091062Abstract: The disclosure relates to an implantable ocular drainage device for controlling intraocular pressure (IOP) comprising at least one drainage channel, and at least one magnetic control mechanism. The at least one magnetic control mechanism is a magnetic valve mechanism configured to regulate flow in the at least one drainage channel.Type: ApplicationFiled: October 5, 2021Publication date: March 21, 2024Inventors: Inês Carolina Figueiredo Pereira, Rosanne Francisca Van De Wijdeven, Sebastian Fredrich, Albertus Petrus Hendricus Johannes Schenning, Hans Markus Wyss, Helena Jacqueline Maria Beckers, Jacob Marinus Jan Den Toonder
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Patent number: 9752904Abstract: The present disclosure relates to an arrangement for providing information about a flow rate of a fluid, comprising: a fluid inlet opening, at least one flow channel, and at least one porous zone located above the at least one flow channel, wherein the surface size and position of the at least one porous zone relative to the fluid inlet opening defines the evaporation rate of a fluid, arranged such that when a fluid is injected through the fluid inlet opening the fluid flows via hydraulic pressure through the at least one flow channel and then through the respective at least one porous zone.Type: GrantFiled: May 19, 2016Date of Patent: September 5, 2017Assignee: Stichting IMEC NederlandInventors: Marcel Arie Günther Zevenbergen, Rajesh Mandamparambil, Chuan Nie, Arnoldus Joannes Hubertus Frijns, Jacob Marinus Jan Den Toonder
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Publication number: 20160349090Abstract: The present disclosure relates to an arrangement for providing information about a flow rate of a fluid, comprising: a fluid inlet opening, at least one flow channel, and at least one porous zone located above the at least one flow channel, wherein the surface size and position of the at least one porous zone relative to the fluid inlet opening defines the evaporation rate of a fluid, arranged such that when a fluid is injected through the fluid inlet opening the fluid flows via hydraulic pressure through the at least one flow channel and then through the respective at least one porous zone.Type: ApplicationFiled: May 19, 2016Publication date: December 1, 2016Applicant: Stichting IMEC NederlandInventors: Marcel Arie Günther Zevenbergen, Rajesh Mandamparambil, Chuan Nie, Arnoldus Joannes Hubertus Frijns, Jacob Marinus Jan Den Toonder
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Patent number: 9493822Abstract: The present invention relates to a device for the specific selection of target molecules, wherein immobilized capture molecules can be organized in a microarray in the form of spots or lines. In a further aspect the present invention relates to a method of specifically selecting target molecules in a reaction zone, as well as the use of such a device for specifically selecting target molecules, e.g. for target enrichment, or microarray based genome selection (MGS).Type: GrantFiled: August 26, 2010Date of Patent: November 15, 2016Assignee: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Pieter Jan Van Der Zaag, Harma Feitsma, Jacob Marinus Jan Den Toonder, Reinhold Wimberger-Friedl
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Publication number: 20150369772Abstract: The invention relates to a method and an apparatus (100) for the processing of nucleotide sequences. An apparatus (100) according to an embodiment of the invention comprises an array of electrodes (120a,120b, . . . ), wherein at least one nanoball (NB) comprising replications of a nucleotide sequence (1,2) of interest is attached to an electrode to which only one nanoball (NB) of that size can be attached at the same time. Thus a unique association of electrodes (120a,120b, . . . ) to nucleotide sequences (1,2) of interest can be achieved. The nanoballs (NB) are preferably produced by rolling circle amplification. Application of attractive and/or repulsive electric potentials to the electrodes (120a,120b, . . . ) can be used to control the attachment of nanoballs (NB). The measurement of changes in the capacitance of electrodes (120a,120b, . . .Type: ApplicationFiled: January 23, 2014Publication date: December 24, 2015Inventors: ANJA VAN DE STOLPE, HARMA MARTINE FEITSMA, PIETER JAN VAN DER ZAAG, REINHOLD WIMBERGER-FRIEDL, JACOB MARINUS JAN DEN TOONDER, ANKE PIERIK, FREEK VAN HEMERT
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Patent number: 9108220Abstract: According to an aspect of the present invention, a device for fragmenting molecules in a sample by ultrasound is provided. The device comprises a planar-shaped cartridge and a fragmentation instrument that has a vessel-like shape. By means of applying under-pressure in the fragmentation instrument the cartridge is pulled towards the fragmentation instrument and therefore spatially closes a fluid compartment that is comprised by the fragmentation instrument. Afterwards, an ultrasound treatment of the sample, which is comprised in a sample compartment of the cartridge, may be processed. A sealing layer is provided in between the cartridge and the fragmentation instrument in order to hold the fixation of the cartridge tightly and in order to provide for leakage prevention out of the fluid compartment.Type: GrantFiled: June 5, 2012Date of Patent: August 18, 2015Assignee: Koninklijke Philips N.V.Inventors: Cristian Bogdan Craus, Jacob Marinus Jan Den Toonder, Roel Penterman, Pieter Jan Van Der Zaag
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Patent number: 8932540Abstract: A device for transporting magnetic or magnetizable beads over a transport surface includes a chamber holding magnetic or magnetizable beads in a fluid, a transport element including the transport surface within the chamber, and a current wire structure including at least two sets of meandering current wires arranged on a side of the transport element opposite to the transport surface. The at least two sets are displaced with respect to each other in at least two directions. A switching unit switches currents individually applied to the sets of current wires according to a current driving scheme resulting in a transport of the beads over the transport surface.Type: GrantFiled: September 6, 2010Date of Patent: January 13, 2015Assignee: Koninklijkle Philips N.V.Inventors: Jacob Marinus Jan Den Toonder, Pieter Jan Van Der Zaag, Hao Chieh Chao
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Patent number: 8932811Abstract: The present invention relates to a method for determining the sequence of a nucleic molecule. Herein a capture oligonucleotide probe is attached to an encoded microcarrier, wherein the code of said microcarrier identifies the sequence of said oligonucleotide probe. The capture oligonucleotide probe is hybridized with a sample comprising nucleic acids molecules, wherein said DNA fragment comprises a sequence which is complementary to the sequence of the capture oligonucleotide probe. The sequence of the DNA molecule is determined, wherein the capture oligonucleotide probe serves as a primer for a DNA polymerase, in the case of single molecule sequencing this is a sequencing primer. After the sequence determination, the nucleotide sequence of the capture oligonucleotide probe is identified by determining the code on the microcarrier, which corresponds with the capture oligonucleotide probe.Type: GrantFiled: February 26, 2010Date of Patent: January 13, 2015Assignee: Koninklijke Philips N.V.Inventors: Anja Van De Stolpe, Jacob Marinus Jan Den Toonder, Pieter Jan Van Der Zaag
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Publication number: 20140193305Abstract: According to an aspect of the present invention, a device for fragmenting molecules in a sample by ultrasound is provided. The device comprises a planar-shaped cartridge and a fragmentation instrument that has a vessel-like shape. By means of applying under-pressure in the fragmentation instrument the cartridge is pulled towards the fragmentation instrument and therefore spatially closes a fluid compartment that is comprised by the fragmentation instrument. Afterwards, an ultrasound treatment of the sample, which is comprised in a sample compartment of the cartridge, may be processed. A sealing layer is provided in between the cartridge and the fragmentation instrument in order to hold the fixation of the cartridge tightly and in order to provide for leakage prevention out of the fluid compartment.Type: ApplicationFiled: June 5, 2012Publication date: July 10, 2014Applicant: KONINKLIJKE PHILIPS N.V.Inventors: Cristian Bogdan Craus, Jacob Marinus Jan Den Toonder, Roel Penterman, Pieter Jan Van Der Zaag
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Patent number: 8711326Abstract: A fluid handling structure to confine immersion liquid in a space between a projection system and a facing surface of a substrate, of a table to support the substrate, or both, is disclosed. The fluid handling structure includes a transponder to dissolve at least some of the gas in a bubble in the immersion liquid or to control a bubble in the immersion liquid so that it avoids entering an optical path of a beam from the projection system.Type: GrantFiled: May 2, 2011Date of Patent: April 29, 2014Assignee: ASML Netherlands B.V.Inventors: Ronald Van Der Ham, Martinus Hendrikus Antonius Leenders, Johannes Catharinus Hubertus Mulkens, Richard Moerman, Michel Riepen, Sergei Shulepov, Koen Steffens, Jan Willem Cromwijk, Johanna Antoinette Maria Sondag-Huethorst, Marco Baragona, Robertus Leonardus Maria In 'T Groen, Ralph Theodorus Hubertus Maessen, Jacob Marinus Jan Den Toonder, Milica Kovacevic-Milivojevic
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Patent number: 8475145Abstract: The present invention provides micro-fluidic systems, a method for the manufacturing of such a micro-fluidic system and a method for controlling or manipulating a fluid flow through micro-channels of a such a micro-fluidic system. Herefore, an inner side of a wall of a microchannel is provided with actuator elements which can change shape and orientation as a response to an external stimulus. Through this change of shape and orientation the flow of a fluid through a microchannel may be controlled and manipulated.Type: GrantFiled: February 8, 2006Date of Patent: July 2, 2013Assignee: Koninklijke Philips Electronics N.V.Inventors: Jacob Marinus Jan Den Toonder, Menno Willem Jose Prins, Hendrik Roelof Stapert, Dirk Jan Broer
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Publication number: 20120171085Abstract: The present invention relates to a device (24) for transporting magnetic or magnetizable beads (10) over a transport surface (12). It comprises a chamber (26) comprising magnetic or magnetizable beads (10) in a fluid (28), a transport element (14) including said transport surface (12) within said chamber (26) over which said beads (10) shall be transported, a current wire structure (20) comprising at least two sets (20a, 20b, 20c) of meandering current wires arranged on a side of said transport element (14) opposite to said transport surface (12), said at least two sets (20a, 20b, 20c) being displaced with respect to each other in at least two directions, and a switching unit (32) for individually switching currents (1a, 1b, 1c) individually applied to said sets of current wires according to a current driving scheme resulting in a transport of said beads (10) over said transport surface (12).Type: ApplicationFiled: September 6, 2010Publication date: July 5, 2012Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Jacob Marinus Jan Den Toonder, Pieter Jan Van Der Zaag, Hao Chieh Chao
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Publication number: 20120165219Abstract: The present invention relates to a device for the specific selection of target molecules, comprising: (a) at least one reaction zone comprising a microarray, wherein the microarray comprises a substrate, on which one or more species of capture molecules are immobilized, comprising one or more temperature control and/or regulating units for controlling and/or regulating the temperature within the zone; (b) at least one non-reaction zone comprising one or more temperature control and/or regulating units for controlling and/or regulating the temperature within the zone, which is in fluid connection with the reaction zone; and (c) at least one transportation means capable of generating and/or regulating a fluid flow between said reaction zone (a) and said non-reaction zone comprising one or more temperature control and/or regulating units (b).Type: ApplicationFiled: August 26, 2010Publication date: June 28, 2012Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Pieter Jan Van Der Zaag, Harma Feitsma, Jacob Marinus Jan Den Toonder, Reinhold Wimberger-Friedl
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Patent number: 8102636Abstract: The present invention relates to a magnetic field generation device comprising a magnetic field generating element (101) and a limiter (103) for limiting a magnitude of a current through the magnetic field generating element (101).Type: GrantFiled: August 10, 2007Date of Patent: January 24, 2012Assignee: Koninklijke Philips Electronics N.V.Inventors: Mark Thomas Johnson, Jacob Marinus Jan Den Toonder, Murray Fulton Gillies, Marc Wilhelmus Gijsbert Ponjee
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Publication number: 20110311975Abstract: The present invention relates to a method for determining the sequence of a nucleic molecule. Herein a capture oligonucleotide probe is attached to an encoded microcarrier, wherein the code of said microcarrier identifies the sequence of said oligonucleotide probe. The capture oligonucleotide probe is hybridized with a sample comprising nucleic acids molecules, wherein said DNA fragment comprises a sequence which is complementary to the sequence of the capture oligonucleotide probe. The sequence of the DNA molecule is determined, wherein the capture oligonucleotide probe serves as a primer for a DNA polymerase, in the case of single molecule sequencing this is a sequencing primer. After the sequence determination, the nucleotide sequence of the capture oligonucleotide probe is identified by determining the code on the microcarrier, which corresponds with the capture oligonucleotide probe.Type: ApplicationFiled: February 26, 2010Publication date: December 22, 2011Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Anja Van De Stolpe, Jacob Marinus Jan Den Toonder, Pieter Jan Van Der Zaag
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Publication number: 20110292357Abstract: A fluid handling structure to confine immersion liquid in a space between a projection system and a facing surface of a substrate, of a table to support the substrate, or both, is disclosed. The fluid handling structure includes a transponder to dissolve at least some of the gas in a bubble in the immersion liquid or to control a bubble in the immersion liquid so that it avoids entering an optical path of a beam from the projection system.Type: ApplicationFiled: May 2, 2011Publication date: December 1, 2011Applicant: ASML NETHERLANDS B.V.Inventors: Ronald Van Der Ham, Martinus Hendrikus Antonius Leenders, Johannes Catharinus Hubertus Mulkens, Richard Moerman, Michel Riepen, Sergei Shulepov, Koen Steffens, Jan Willem Cromwijk, Johanna Antoinette Maria Sondag-Huethorst, Marco Baragona, Robertus Leonardus Maria In 'T Groen, Ralph Theodorus Hubertus Maessen, Jacob Marinus Jan Den Toonder, Milica Kovacevic-Milivojevic
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Publication number: 20100228082Abstract: A device or support, system and method are provided for precisely targeted and/or highly controlled interaction with a targeted cell or tissue in a body, with the support providing an ergonomic connecting interface for selectively connecting the support to a cell or tissue with at least minimal adverse affect to such cell or tissue, the system providing a remote facility that may be operatively associated with the support, and the method providing steps for employing the support and/or system so as to, inter alia, improve treatment, diagnostic and/or monitoring techniques and increase sensitivity and specificity with respect to interacting with, for example, diseased or abnormal cells or tissue without adversely effecting surrounding healthy cells or tissue, and/or the body in general.Type: ApplicationFiled: April 12, 2007Publication date: September 9, 2010Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Hans Zou, Stein Kuiper, Bernardus Hendrikus Wilhelmus Hendriks, Jan Frederik Suijver, Anke Pierik, Judith Margreet Rensen, Johan Frederik Dijksman, Jeff Shimizu, Jacob Marinus Jan Den Toonder
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Publication number: 20100183456Abstract: The present invention provides a micro-fluidic system, a method for manufacturing a micro-fluidic system and a method for controlling or manipulating a fluid flow through micro-channels of such a micro-fluidic system. The inner side of the wall of the micro-channel is provided with actuator elements. These actuator elements have a shape, an orientation and a geometry that includes a varying cross sectional area along a longitudinal axis. The varying cross sectional area includes one or more openings along the longitudinal axis of the actuator element. The actuator elements can change in shape and orientation as a response to an external stimulus. Through this change of the shape and orientation, the flow of a fluid through a micro-channel may be controlled and manipulated.Type: ApplicationFiled: August 8, 2007Publication date: July 22, 2010Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Jacob Marinus Jan Den Toonder, Lucas Van Rijsewijk, Dirk Jan Broer
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Publication number: 20100165534Abstract: The present invention relates to a magnetic field generation device comprising a magnetic field generating element (101) and a limiter (103) for limiting a magnitude of a current through the magnetic field generating element (101).Type: ApplicationFiled: August 10, 2007Publication date: July 1, 2010Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Mark Thomas Johnson, Jacob Marinus Jan Den Toonder, Murray Fulton Gillies, Marc Wilhelmus Gijsbert Ponjee
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Publication number: 20100132797Abstract: The present invention provides a microfluidic system comprising at least one microchannel (18) having an inner wall (17). The microfluidic system comprises attached to the inner wall (17) of the at least one microchannel (18) a plurality of ciliary N actuator elements (10a-d) and at least one floating current wire (14a-d) present in the at least one microchannel (18) for applying a magnetic field to the plurality of ciliary actuator elements (10a-d) for changing their shape and/or orientation. The present invention also provides a method for the manufacturing of such microfluidic systems and to a method for controlling a fluid flow through a microchannel (18) of such a microfluidic system.Type: ApplicationFiled: March 12, 2008Publication date: June 3, 2010Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Menno Willem Jose Prins, Johannes Wilhelmus Weekamp, Jacob Marinus Jan Den Toonder