Patents by Inventor Jacob MURRAY

Jacob MURRAY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for preparing and using mitochondrial uncouplers
    Patent number: 11896591
    Abstract: This disclosure provides compounds of Formula I, II, and III and pharmaceutically acceptable salts thereof for use as mitochondrial uncouplers, where the variables, e.g. R1-R9, X1, X2, and Y1 are defined in the specification. The disclosure also provides pharmaceutical compositions comprising a compound or pharmaceutically acceptable salt of Formula I, II, or III, alone or in combination with another active compound. Compounds and compositions of Formula I, II, and III are useful for treating or preventing certain conditions such as obesity, type II diabetes, fatty liver disease, insulin resistance, Parkinson's disease, ischemia reperfusion injury, heart failure, non-alcoholic fatty liver disease (NALFD), and non-alcoholic steatohepatitis (NASH). Compounds of Formula I, II, and III are also useful for regulating glucose homeostatis and insulin action.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: February 13, 2024
    Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Kyle Hoehn, Webster L. Santos, Elizabeth S. Childress, Yumin Dai, Jacob Murray, Jose Santiago-Rivera
  • COMPOSITIONS AND METHODS FOR PREPARING AND USING MITOCHONDRIAL UNCOUPLERS
    Publication number: 20200323846
    Abstract: This disclosure provides compounds of Formula I, II, and III and pharmaceutically acceptable salts thereof for use as mitochondrial uncouplers, where the variables, e.g. R1-R9, X1, X2, and Y1 are defined in the specification. The disclosure also provides pharmaceutical compositions comprising a compound or pharmaceutically acceptable salt of Formula I, II, or III, alone or in combination with another active compound. Compounds and compositions of Formula I, II, and III are useful for treating or preventing certain conditions such as obesity, type II diabetes, fatty liver disease, insulin resistance, Parkinson's disease, ischemia reperfusion injury, heart failure, non-alcoholic fatty liver disease (NALFD), and non-alcoholic steatohepatitis (NASH). Compounds of Formula I, II, and III are also useful for regulating glucose homeostatis and insulin action.
    Type: Application
    Filed: May 22, 2018
    Publication date: October 15, 2020
    Applicants: University of Virgina Patent Foundation, Virginia Tech Intellectual Properties, Inc., NewSouth Innovations Pty Limited
    Inventors: Kyle HOEHN, Webster L. SANTOS, Elizabeth S. CHILDRESS, Yumin DAI, Jacob MURRAY, Jose SANTIAGO-RIVERA