Abstract: Genetic sequence information representative of a first set of organisms is accessed. The first set of organisms can include organisms that include an organism feature and organisms that do not include the organism feature. A latent space representation of k-mers within the first genetic sequence information is generated, for instance using a generative topic model. A generative interpolation model is generated using the latent space representation. The generative interpolation model is configured to classify genetic sequence information representation of a target organism to determine whether the target organism includes the organism feature. Second genetic sequence information representation of each of a second set of organisms is accessed. The generative interpolation model is then applied to the second genetic sequence information to identify which of the second set of organisms are likely to include the organism feature.