Abstract: This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides a process for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I.

Abstract: This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I.

Abstract: This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides a process for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I.

Abstract: A system and method of switching packets and/or cells, which includes a switching apparatus having a plurality of input units that receive at least one packet to be transferred by the switching apparatus. A plurality of output units transfer the packet out of the switching apparatus. A switch unit transfers the packet from one of the input units to one of the output units. Each input unit includes at least one input queue that temporarily holds the packet to be transferred by the switching apparatus. Each input unit also includes a respective unicast credit count unit that allows the packet to be transferred out from the queue when a current unicast credit value determined by the unicast credit count unit is at least predetermined value. Each output unit includes at least one output queue that receives the packet as switched by the switch unit, and which is to be transferred out of the switching apparatus.

Abstract: A system and method of transferring packets/cells and messages within a switching apparatus that includes a plurality of input units, a packet/cell switch element, a message controller, and a plurality of output units. It is identified as to whether or not an item to be transferred from one of the input units or output units to another of the input units or output units is a message or a packet/cell. If the item to be transferred is a packet/cell, the packet/cell is transferred from one of the input units to one of the output units using links dedicated for packet/cell transfer and a packet/cell switch element. If the item to be transferred is a message, the message is transferred from one of the input units or output units to another of the input units or output units using links dedicated for message transfer and a message controller.

Abstract: The invention relates to relatively short peptides (termed ?-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. The ?-conotoxins, as described herein, are useful for as neuromuscular blocking agents, such as muscle relaxants.

Abstract: A system and method of scheduling packets or cells for a switch device that includes a plurality of input ports each having at least one input queue, a plurality of switch units, and a plurality of output ports. There is generated, by each input port having a packet or cell in its at least one queue, a request to output the corresponding packet or cell to each of the output ports to which a corresponding packet or cell is to be sent to, wherein the request includes a specific one of the plurality of switch units to be used in a transfer of the packet or cell from the corresponding input port to the corresponding output port, the specific one of the plurality of switch units being selected according to a first priority scheme. Access is granted, per output port per switch unit, to the request made, the granting being based on a second priority scheme. Grants are accepted per input port per switch unit, the accepting being based on a third priority scheme.

Abstract: A network switching system includes transceiver devices respectively provided for a plurality of input line cards. The switching system also includes transceiver devices respective provided for a plurality of output line cards. The switching system further includes a switch device communicatively coupled to each of the plurality of input line cards and the plurality of output line cards. The switch device includes a crosspoint matrix for communicatively connecting one of the input line cards to one of the output line cards. The switch device is capable of operating in either a crosspoint mode for routing cells or packets from one of the input line cards to one of the output line cards, or a scheduler mode for controlling flow of cells and/or packets through at least one other switch device.

Abstract: Methods and compositions are provided for protecting or enhancing a responsive cell, tissue, organ or body part function or viability in vivo, in situ or ex vivo in mammals, including human beings, by systemic or local administration of an erythropoietin receptor activity modulator, such as an recombinant tissue protective cytokine.