Patents by Inventor Jacob P. Hieble

Jacob P. Hieble has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of treating benign prostatic hypertrophy
    Patent number: 4755507
    Abstract: Method of producing symptomatic relief in benign prostatic hypertrophy by administering 3-alkyl-6-halo-2,3,4,5-tetrahydro-1H-3-benzazepines.
    Type: Grant
    Filed: October 27, 1987
    Date of Patent: July 5, 1988
    Assignee: SmithKline Beckman Corporation
    Inventor: Jacob P. Hieble
  • Pharmaceutical compositions and methods for producing alpha antagonism
    Patent number: 4496558
    Abstract: Pharmaceutical compositions and methods for producing alpha.sub.2 antagonism utilize, as active ingredients, 6-halo-N-substituted 2,3,4,5-tetrahydro-1H-3-benzazepines. These compositions are particularly useful for lowering intraocular pressure and for the treatment of abnormal cardiovascular conditions such as, for example, congestive heart failure, angina pectoris and thrombosis. The compositions and compounds of this invention, also, produce a reduction in blood pressure in hypertensive subjects and are, therefore, useful as antihypertensive agents.
    Type: Grant
    Filed: January 26, 1983
    Date of Patent: January 29, 1985
    Assignee: Smithkline Beckman Corporation
    Inventors: Robert M. DeMarinis, Jacob P. Hieble, William D. Matthews
  • Pharmaceutical compositions and method of producing alpha.sub.2 antagonism
    Patent number: 4465677
    Abstract: Pharmaceutical compositions and method of producing alpha.sub.2 antagonism by administering N-substituted 2,3,4,5-tetrahydro-1H-3-benzazepines.
    Type: Grant
    Filed: July 14, 1982
    Date of Patent: August 14, 1984
    Assignee: Smithkline Beckman Corporation
    Inventors: Robert M. DeMarinis, Jacob P. Hieble, William D. Matthews
  • Method of producing alpha.sub.2 antagonism
    Patent number: 4352809
    Abstract: Method of producing alpha.sub.2 antagonism by administering thiadiazolo- and oxadiazolotetrahydroisoquinoline compounds.
    Type: Grant
    Filed: September 4, 1981
    Date of Patent: October 5, 1982
    Assignee: Smithkline Corporation
    Inventors: William E. Bondinell, Robert M. DeMarinis, Jacob P. Hieble, Robert G. Pendleton