Patents by Inventor Jacob P.R. Jacobsen

Jacob P.R. Jacobsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods of enhancing 5-hydroxytryptophan bioavailability
    Patent number: 11337963
    Abstract: Provided are methods of enhancing bioavailability of enterally administered 5-hydroxytryptophan (5-HTP) in a subject in need thereof, said method comprising enterally co-administering low-dose carbidopa with said 5-HTP, as well as pharmaceutical formulations useful for the same. In some embodiments, the 5-HTP and/or low-dose carbidopa are provided as slow-release formulation(s).
    Type: Grant
    Filed: January 28, 2019
    Date of Patent: May 24, 2022
    Assignee: Duke University
    Inventors: Jacob P. R. Jacobsen, Marc G. Caron
  • COMPOSITIONS AND METHODS OF ENHANCING 5-HYDROXYTRYPTOPHAN BIOAVAILABILITY
    Publication number: 20210346345
    Abstract: Provided are methods of enhancing bioavailability of enterally administered 5-hydroxytryptophan (5-HTP) in a subject in need thereof, said method comprising enterally co-administering low-dose carbidopa with said 5-HTP, as well as pharmaceutical formulations useful for the same. In some embodiments, the 5-HTP and/or low-dose carbidopa are provided as slow-release formulation(s).
    Type: Application
    Filed: January 28, 2019
    Publication date: November 11, 2021
    Inventors: JACOB P.R. JACOBSEN, MARC G. CARON
  • USE OF SUSTAINED-RELEASE 5-HYDROXYTRYPTOPHAN IN TREATING GASTROINTESTINAL DISORDERS
    Publication number: 20210290593
    Abstract: The present invention provides, inter alia, methods for treating or ameliorating a gastrointestinal (GI) condition such as constipation in a subject in need thereof, using a sustained release formulation of 5-hydroxytryptophan (5-HTP SR). A kit comprising 5-HTP SR is also provided.
    Type: Application
    Filed: July 10, 2019
    Publication date: September 23, 2021
    Inventors: Jacob P.R. Jacobsen, Marc G. Caron, Michael Gershon, Kara Margolis
  • SLOW-RELEASE FORMULATIONS OF 5-HYDROXYTRYPTOPHAN AS AN ADJUNCT TO PRO-SEROTONERGIC THERAPIES
    Publication number: 20160374957
    Abstract: The present invention concerns the treatment of serotonergic dysregulation disordersand/or augmentation of serotonin levels in the brain by add-on treatments to serotonin enhancers, and slow-release formulations of 5-hydroxytryptophan (5-HTP) therefor.
    Type: Application
    Filed: September 8, 2016
    Publication date: December 29, 2016
    Inventors: Jacob P.R. Jacobsen, Marc G. Caron
  • Slow-release formulations of 5-hydroxytryptophan as an adjunct to pro-serotonergic therapies
    Patent number: 9468627
    Abstract: The present invention concerns the treatment of serotonergic dysregulation disorders and/or augmentation of serotonin levels in the brain by add-on treatments to serotonin enhancers, and slow-release formulations of 5-hydroxytryptophan (5-HTP) therefor.
    Type: Grant
    Filed: April 19, 2013
    Date of Patent: October 18, 2016
    Assignee: Duke University
    Inventors: Jacob P. R. Jacobsen, Marc G. Caron
  • SLOW-RELEASE FORMULATIONS OF 5-HYDROXYTRYPTOPHAN AS AN ADJUNCT TO PRO-SEROTONERGIC THERAPIES
    Publication number: 20130230577
    Abstract: The present invention concerns the treatment of serotonergic dysregulation disorders and/or augmentation of serotonin levels in the brain by add-on treatments to serotonin enhancers, and slow-release formulations of 5-hydroxytryptophan (5-HTP) therefor.
    Type: Application
    Filed: April 19, 2013
    Publication date: September 5, 2013
    Applicant: Duke University
    Inventors: Jacob P.R. Jacobsen, Marc G. Caron