Abstract: A shoe cover for a shoe, the shoe cover comprising a lower periphery having a strip of projections and a slider with a tab. A first edge extends from one end of the lower periphery has a strip of projections and a slider with a tab. A second edge extends from another end of the lower periphery also has a strip of projections. The first and second edges are reversibly fastenable by pulling the slider along the strips of projections of the first and second edges. The strip of projections on the lower periphery is reversibly fastenable to a strip of projections on a shoe. The tabs on the sliders are interlockable where the sliders are pulled to the end of the strips of projections.

Abstract: A method for selecting a compound or a composition of matter for treatment of hyperproliferative disorders of the prostate in a mammal by administering the compound or the composition to a mammal (in vivo) or to a prostate cell culture (in vitro) and assessing the effect of the compound or the composition on the content of the transcription and/or translation product of a gene under the influence of at least one regulatory region of Vitamin D upregulated protein 1 (VDUP-1) gene and optionally assessing the effect of the compound or the composition on the content of apoptosis signalling kinase (ASK-1) and/or thioredoxin, in the prostate cells of said mammal or in the cells of the prostate cell culture. A substance for use in the treatment of hyperproliferative disorders of the prostate selected by the above method, a pharmaceutical composition comprising said substance, a method of treatment by of a hyperproliferative disorder of the prostate.