Abstract: Novel crystal modifications of (5S)-5-[4-(5-chloro-pyridin-2-yloxy)-piperidine-1-sulfonylmethyl]-5-methyl-imidazolidine-2,4-dione are disclosed together with processes for preparing such modifications, pharmaceutical compositions comprising such a modification, and the use of such a modification in therapy.

Abstract: A package comprising a package container structure having an open end leading into an interior chamber therein, a package lid structure mounted over the open end of the package container structure in generally sealed relation with the interior chamber thereof so as to be moved into opening relation thereto, and a device for use with a medicament vial disposed within the sealed interior chamber. The device and package container structure have interengageable elements disposed out of interengagement when the device is disposed within the sealed interior chamber operable when the package lid structure is moved into opening relation and the device is moved out of the open end of the interior chamber to be moved into interengagement. The device and package container structure with the interengaging elements thereof interengaged provide a generally sealed interior space including the interior chamber within which a medicament vial is contained in cooperating relation with the device.

Abstract: A method of utilizing an apparatus of the type comprising a vial container hazardous material in the vial container in a condition requiring a diluent to be mixed therewith to form the liquid solution, and an assemblage carried by the vial container for providing (1) a sealed medicament chamber within the vial container within which the hazardous material is disposed, (2) a filter vented control chamber and (3) a sealed variable volume control chamber between the vented control chamber and the medicament chamber. The method is such as to enable an open end of a syringe needle of a diluent syringe having a syringe chamber containing diluent in communication therewith to be moved into and withdrawn successively from the chambers so as to mix the diluent with the hazardous material. The method also contemplates procedures for separately refilling a dosage syringe and for relieving any residual pressure in the vial chamber with the use of an empty syringe prior to initial or final refilling of a dosage syringe.

Abstract: An apparatus comprising a vial container hazardous material in the vial container in a condition requiring a diluent to be mixed therewith to form the liquid solution, and an assemblage carried by the vial container for providing (1) a sealed medicament chamber within the vial container within which the hazardous material is disposed, (2) a filter vented control chamber and (3) a sealed variable volume control chamber between the vented control chamber and the medicament chamber, the arrangement being such as to enable an open end of a syringe needle of a diluent syringe having a syringe chamber containing diluent in communication therewith to be moved into and withdrawn successively from the chambers so as to mix the diluent with the hazardous material in such a way as to substantially prevent the hazardous material from entering the immediate atmospheric environment.