Patents by Inventor Jacob Plattner
Jacob Plattner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20180044355Abstract: Compounds of Formula II, wherein X is selected from chloro, fluoro, bromo and iodo, R1 and R2 are each independently selected from H, —CH3, —CH2CH3, —CH2CH2CH3, or —CH(CH3)2; compositions containing them, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.Type: ApplicationFiled: October 24, 2017Publication date: February 15, 2018Applicants: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED, ANACOR PHARMACEUTICALS INC.Inventors: M. R. K. (DICKON) ALLEY, VINCENT S. HERNANDEZ, JACOB PLATTNER, XIANFENG LI, DAVID BARROS-AGUIRRE, ILARIA GIORDANO
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Publication number: 20160251380Abstract: Compounds of Formula II, wherein X is selected from chloro, fluoro, bromo and iodo, R1 and R2 are each independently selected from H, —CH3, —CH2CH3, —CH2CH2CH3, or —CH(CH3)2; compositions containing them, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.Type: ApplicationFiled: August 8, 2014Publication date: September 1, 2016Inventors: M.R.K. (DICKON) ALLEY, VINCENT S. HERNANDEZ, JACOB PLATTNER, XIANFENG LI, DAVID BARROS-AGUIRRE, ILARIA GIORDANO
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Patent number: 8227459Abstract: Compounds and methods for preventing and treating viral infections are provided. In some embodiments, novel compounds broad-spectrum antiviral activity are provided. In more specific embodiments, the compounds and methods are effective against viruses such as Venezuelan Equine Encephalitis, West Nile Virus, and Hepatitis C.Type: GrantFiled: April 3, 2008Date of Patent: July 24, 2012Assignee: Prosetta Antiviral Inc.Inventors: Jacob Plattner, Colm Kelleher, Vishwanath Lingappa, Beverly Freeman, William Hansen
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Publication number: 20110178071Abstract: Compounds and methods for preventing and treating viral infections are provided. In some embodiments, novel compounds broad-spectrum antiviral activity are provided. In more specific embodiments, the compounds and methods are effective against viruses such as Venezuelan Equine Encephalitis, West Nile Virus, and Hepatitis C.Type: ApplicationFiled: April 3, 2008Publication date: July 21, 2011Inventors: Jacob Plattner, Colm Kelleher, Vishwanath Lingappa, Beverly Freeman, William Hansen
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Publication number: 20110124597Abstract: This invention provides, among other things, novel compounds useful for treating bacterial infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.Type: ApplicationFiled: August 31, 2010Publication date: May 26, 2011Applicant: Anacor Pharmaceuticals, Inc.Inventors: Vincent S. HERNANDEZ, Charles DING, Jacob PLATTNER, Michael Richard Kevin ALLEY, Yong-Kang ZHANG, Yanchen ZHANG
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Publication number: 20080139611Abstract: A skin disorder, a disorder associated with pain, fever, or inflammation, a proliferative disorder, or an ocular disorder is treated by topically administering a pharmaceutically acceptable formulation containing a therapeutically effective amount of a 4-phenylaminoquinoline compound.Type: ApplicationFiled: October 16, 2007Publication date: June 12, 2008Inventors: Jan Wasley, Jacob Plattner
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Patent number: 7332476Abstract: Antimicrobial macrolide and ketolide compounds are provided having formulas XII: as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.Type: GrantFiled: April 23, 2004Date of Patent: February 19, 2008Assignee: Novartis AGInventors: Matthew T. Burger, Georgia Law Carroll, Daniel Chu, Xiaodong Lin, Jacob Plattner, Alice Rico
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Publication number: 20070293457Abstract: Methods of treating anti-inflammatory conditions through the use of boron-containing small molecules are disclosed.Type: ApplicationFiled: February 16, 2007Publication date: December 20, 2007Inventors: Stephen Baker, Virginia Sanders, Tsutomu Akama, Carolyn Bellinger-Kawahara, Yvonne Freund, Kirk Maples, Jacob Plattner, Yong-Kang Zhang, Huchen Zhou, Vincent Hernandez
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Publication number: 20070286822Abstract: Compounds, compositions and methods are provided which are useful in the treatment of periodontal disease.Type: ApplicationFiled: June 12, 2007Publication date: December 13, 2007Applicant: ANACOR PHARMACEUTICALS INC.Inventors: Virginia Sanders, Kirk Maples, Jacob Plattner, Carolyn Bellinger-Kawahara
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Publication number: 20070265226Abstract: Compositions and methods of use of boron derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by fungi, yeast, bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.Type: ApplicationFiled: May 2, 2007Publication date: November 15, 2007Applicant: Anacor PharmaceuticalsInventors: Ving Lee, Jacob Plattner, Stephen Benkovic, Stephen Baker, Kirk Maples, Carolyn Bellinger-Kawahara, Tsutomu Akama, Yong-Kang Zhang, Rajeshwar Singh, Vittorio Sauro
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Publication number: 20070155699Abstract: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.Type: ApplicationFiled: August 16, 2006Publication date: July 5, 2007Applicant: Anacor PharmaceuticalsInventors: Stephen Baker, Tsutomu Akama, Michael Alley, Steven Benkovic, Michael DiPierro, Vincent Hernandez, Karin Hold, Isaac Kennedy, Igor Likhotvorik, Weimin Mao, Kirk Maples, Jacob Plattner, Fernando Rock, Virginia Sanders, Aaron Stemphoski, George Yiannikouros, Siead Zegar, Yong-Kang Zhang, Huchen Zhou
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Publication number: 20060234981Abstract: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.Type: ApplicationFiled: February 16, 2006Publication date: October 19, 2006Applicant: Anacor PharmaceuticalsInventors: Stephen Baker, Tsutomu Akama, Carolyn Bellinger-Kawahara, Vincent Hernandez, Karin Hold, James Leyden, Kirk Maples, Jacob Plattner, Virginia Sanders, Yong-Kang Zhang
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Publication number: 20060019927Abstract: Compositions and methods of use of borinic acid complexes, especially hydroxyquinoline, imidazole and picolinic acid derivatives, as anti-viral agents as well as therapeutic agents for the treatment of diseases caused by viruses are described.Type: ApplicationFiled: June 14, 2005Publication date: January 26, 2006Inventors: Carolyn Bellinger-Kawahara, Kirk Maples, Jacob Plattner
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Publication number: 20050054644Abstract: Compositions and methods of use of borole derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.Type: ApplicationFiled: June 15, 2004Publication date: March 10, 2005Inventors: Ving Lee, Jacob Plattner, Stephen Benkovic, Stephen Baker, Kirk Maples, Carolyn Bellinger-Kawahara, Tsutomu Akama, Yong-Kang Zhang, Rajeshwar Singh, Vittorio Sauro
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Publication number: 20050009764Abstract: Antimicrobial macrolide and ketolide compounds are provided having formulas XII: as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.Type: ApplicationFiled: April 23, 2004Publication date: January 13, 2005Applicant: Chiron CorporationInventors: Matthew Burger, Georgia Carroll, Daniel Chu, Xiaodong Lin, Jacob Plattner, Alice Rico
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Patent number: 6756359Abstract: Antimicrobial macrolide compounds are provided having formulas II: as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.Type: GrantFiled: July 3, 2002Date of Patent: June 29, 2004Assignee: Chiron CorporationInventors: Daniel Chu, Matthew Burger, Xiaodong Lin, Georgia Law Carroll, Jacob Plattner, Alice Rico
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Publication number: 20030125266Abstract: Antimicrobial macrolide compounds are provided having formulas II: 1Type: ApplicationFiled: July 3, 2002Publication date: July 3, 2003Inventors: Daniel Chu, Matthew Burger, Xiaodong Lin, Georgia Law Carroll, Jacob Plattner, Alice Rico
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Patent number: 4550163Abstract: The present invention encompasses a method for determining ligands in test samples comprising intermixing with the test sample a ligand analog-irreversible enzyme inhibitor conjugate and a binding protein bindable to the ligand and the ligand analog-irreversible enzyme inhibitor conjugate and wherein the amount of ligand analog-irreversible enzyme inhibitor conjugate bound by the binding protein is related to the amount of ligand in the test sample, said binding protein inactivating the irreversible enzyme inhibitor when bound to the ligand analog portion of the conjugate; intermixing an enzyme which is irreversibly inhibited by the ligand analog-irreversible enzyme inhibitor conjugate unbound by the binding protein; and intermixing substrate to the enzyme and monitoring the enzyme substrate reaction.The invention also includes ligand analog-irreversible enzyme inhibitor conjugates useful as reagents in practicing the method.Type: GrantFiled: January 26, 1981Date of Patent: October 29, 1985Assignee: Abbott LaboratoriesInventors: Houston F. Voss, Jacob Plattner, Thomas R. Herrin
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Patent number: 4273866Abstract: The present invention encompasses a method for determining ligands in test samples comprising intermixing with the test sample a ligand analog-irreversible enzyme inhibitor conjugate and a binding protein bindable to the ligand and the ligand analog-irreversible enzyme inhibitor conjugate and wherein the amount of ligand analog-irreversible enzyme inhibitor conjugate bound by the binding protein is related to the amount of ligand in the test sample, said binding protein inactivating the irreversible enzyme inhibitor when bound to the ligand analog portion of the conjugate; intermixing an enzyme which is irreversibly inhibited by the ligand analog-irreversible enzyme inhibitor conjugate unbound by the binding protein; and intermixing substrate to the enzyme and monitoring the enzyme substrate reaction.The invention also includes ligand analog-irreversible enzyme inhibitor conjugates useful as reagents in practicing the method.Type: GrantFiled: February 5, 1979Date of Patent: June 16, 1981Assignee: Abbott LaboratoriesInventors: Houston F. Voss, Jacob Plattner, Thomas R. Herrin