Abstract: Disclosed herein is a method of manufacturing hemostatic particles, which involves heating and mixing a chitosan solution and a gelatin solution to form a chitosan/gelatin solution, adding the chitosan/gelatin mixture to oil containing an emulsifier/surfactant to form a combination of chitosan/gelatin and oil, heating and mixing the combination and then cooling and stirring the combination to form gelatin-chitosan microspheres (GCM), adding an aqueous solution of glutaraldehyde to the combination and stirring to cross-link the GCM, washing the GCM with emulsifier/surfactant to remove the oil, washing the GCM with a solvent to further remove excess oil, washing the GCM with alcohol to remove excess water, and drying the GCM.

Abstract: Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.

Abstract: A method of manufacturing hemostatic particles involves heating and mixing a chitosan solution and a gelatin solution to form a chitosan/gelatin solution, adding the chitosan/gelatin mixture to oil containing an emulsifier/surfactant to form a combination of chitosan/gelatin and oil, heating and mixing the combination and then cooling and stirring the combination to form gelatin-chitosan microspheres (GCM), adding an aqueous solution of glutaraldehyde to the combination and stirring to cross-link the GCM, washing the GCM with emulsifier/surfactant to remove the oil, washing the GCM with a solvent to further remove excess oil, washing the GCM with alcohol to remove excess water, and drying the GCM.

Abstract: Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.

Abstract: Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.

Abstract: Methods, products, and systems for monitoring and improving pipeline infrastructure are disclosed. At least one embodiment of the invention comprises a smart-sensing coating, which is applied to one or more interior surfaces of a pipe or pipeline. The coating may comprise a dual-purpose metamaterial, which itself may comprise a plurality of acoustically active and tunable particles that may be embedded in a low-friction, corrosion-resistant, omniphobic polymer matrix. The particles may comprise a multi-layered assembly with a high-density material core, elastic matrix filler, and a stiff outer shell. The particles may further be specifically engineered to form an acoustic band gap at a chosen ultrasound frequency. At this chosen frequency, the particles are very nearly acoustically opaque, preventing the transmission of any and all sound. As such, the position and distribution of the particles inside the pipelines can be clearly distinguished.

Abstract: Deployable smart acoustic resonance particles have dense cores, compliant matrixes surrounding the cores and stiff outer shells surrounding the matrixes. The particles have mechanical stress sensitivities that provide unique band gap shifts when compressed. Groups of similar particles with similar stress sensitivities and similar band gap shifts are added at different times to hydraulic fluids, as circulated through wells with the fluid and pushed into fractures. A plural, sonic monopole well logging tool is lowered into the well to determine locations and depth of fractures and local pressures by distinct resonance of individual groups.

Abstract: A method of producing modified buoyancy bodies and particulates involves pre-treating one or more substrate surfaces with acid to activate hydroxyl groups, rinsing the substrate surfaces to remove excess acid, functionalizing the pre-treated substrate surfaces with hydrophilic chemical moieties to provide hydrophilic functionality to the substrate, and attaching chemicals, materials, and/or fillers to the substrate surfaces sequentially to produce bodies and/or particles having modified functional attributes.

Abstract: A sound attenuation material includes a plurality of particles, each having a core and an elastic or compliant coating around the core, and a matrix surrounding the plurality of particles, the matrix being less dense than the core. A method of manufacturing sound attenuating materials includes adding an elastic or compliant coating to core particles and drying the coating, mixing the coated core particles into a matrix material, and pouring the mixture into a mold. The core particles are denser than the matrix material.

Abstract: A novel hydrogel wound dressing therapy and methods for making the same. The novel methods comprise forming two biopolymers, chitosan and hyaluronic acid, together into a wound dressing with inherent ability to enhance wound closure. The novel composition of the subject invention comprises cross-linked chitosan/hyaluronic acid hydrogels manufactured according to the methods disclosed having a specific cross-link density that results in a swelling ratio of 20 to 100. Hydrogels manufactured in accordance with the method of the invention dramatically increase healing rates and greatly improves outcomes of wound injuries.

Abstract: A novel hydrogel wound dressing therapy and methods for making the same. The novel methods comprise forming two biopolymers, chitosan and hyaluronic acid, together into a wound dressing with inherent ability to enhance wound closure. The novel composition of the subject invention comprises cross-linked chitosan/hyaluronic acid hydrogels manufactured according to the methods disclosed having a specific cross-link density that results in a swelling ratio of 20 to 100. Hydrogels manufactured in accordance with the method of the invention dramatically increase healing rates and greatly improves outcomes of wound injuries.

Abstract: Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.

Abstract: Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.

Abstract: Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.

Abstract: Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.

Abstract: Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.

Abstract: Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.

Abstract: Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.

Abstract: Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.

Abstract: A surgical tissue adhesive composition contains at least one 1,1-disubstituted electron-deficient olefin macromer. The adhesive composition of the invention has improved biocompatibility as well as controlled biodegradation characteristics and bioactivity. Adhesive co-monomer compositions contain at least one macromer with a pendant oligomer, polymer, or peptide chain as an acrylic ester of the reactive olefin. The polymers formed therefrom have a grafted brush-like nature. The composition is particularly useful for creating an adhesive bond at the junction of living tissue in surgical applications. The adhesive composition may further comprise co-monomer, co-macromer, cross-linker, or inter-penetrating polymer compounds containing peptide sequences that are bioactive or enzyme responsive. The peptide sequences are selected to promote tissue infiltration and healing in a particular biological tissue. The sequences may contain specific cell-adhesion, cell-signaling, and enzyme-cleavable domains.