Abstract: The present invention provides a combination of a Type I protein arginine methyltransferase (Type I PRMT) inhibitor and a Type II protein arginine methyltransferase (Type II PRMT) inhibitor. The present invention also provides methods for treating cancer in a human in need thereof, the methods comprising administering to the human a combination of a Type I PRMT inhibitor and a Type II PRMT inhibitor, together with at least one of: a pharmaceutically acceptable carrier and a pharmaceutically acceptable diluent, thereby treating the cancer in the human. The present invention further provide a pharmaceutical composition comprising a therapeutically effective amount of a Type I PRMT inhibitor and a second pharmaceutical composition comprising a therapeutically effective amount of a Type II PRMT inhibitor.

Abstract: The present invention provides a combination of a Type I protein arginine methyltransferase (Type I PRMT) inhibitor and a Type II protein arginine methyltransferase (Type II PRMT) inhibitor. The present invention also provides methods for treating cancer in a human in need thereof, the methods comprising administering to the human a combination of a Type I PRMT inhibitor and a Type II PRMT inhibitor, together with at least one of: a pharmaceutically acceptable carrier and a pharmaceutically acceptable diluent, thereby treating the cancer in the human. The present invention further provide a pharmaceutical composition comprising a therapeutically effective amount of a Type I PRMT inhibitor and a second pharmaceutical composition comprising a therapeutically effective amount of a Type II PRMT inhibitor.

Abstract: This document relates to hardware protection of differential privacy techniques. One example obtains multiple instances of encrypted telemetry data within a secure enclave and processes the encrypted telemetry data to obtain multiple instances of unencrypted telemetry data. The example also processes, within the secure enclave, the multiple instances of unencrypted telemetry data to obtain a perturbed aggregate. The example also releases the perturbed aggregate from the secure enclave.

Abstract: A system includes determination of a plurality of meta-copysets of a plurality of storage devices, each of the meta-copysets including a first number of storage devices, determination of a first copyset of a second number of storage devices from a first one of the meta-copysets, where the second number is less than the first number, storage of first data in a fault-tolerant format using the first copyset, determination to migrate the first data from a first storage device of the first copyset, and, in response to the determination to migrate the first data, determine a second copyset of the second number of storage devices including a storage device from the first meta-copyset which is not in the first copyset, and the storage devices of the first copyset except for the first storage device of the first copyset and storage of the first data in a fault-tolerant format using the second copyset.

Abstract: This invention relates to methods of treating cancer in a subject in need thereof, e.g., in a human in need thereof, comprising determining the level of 5-Methylthioadenosine phosphorylase (MTAP) polynucleotide or polypeptide or the presence or absence of a mutation in MTAP in a sample from the human, and administering to the human an effective amount of a Type I protein arginine methyltransferase (Type I PRMT) inhibitor if the level of the MTAP polynucleotide or polypeptide is decreased relative to a reference or if a mutation in MTAP polynucleotide or polypeptide is present, thereby treating the cancer in the human.

Abstract: A system includes determination of a plurality of meta-copysets of a plurality of storage devices, each of the meta-copysets including a first number of storage devices, determination of a first copyset of a second number of storage devices from a first one of the meta-copysets, where the second number is less than the first number, storage of first data in a fault-tolerant format using the first copyset, determination to migrate the first data from a first storage device of the first copyset, and, in response to the determination to migrate the first data, determine a second copyset of the second number of storage devices including a storage device from the first meta-copyset which is not in the first copyset, and the storage devices of the first copyset except for the first storage device of the first copyset and storage of the first data in a fault-tolerant format using the second copyset.

Abstract: This document relates to hardware protection of differential privacy techniques. One example obtains multiple instances of encrypted telemetry data within a secure enclave and processes the encrypted telemetry data to obtain multiple instances of unencrypted telemetry data. The example also processes, within the secure enclave, the multiple instances of unencrypted telemetry data to obtain a perturbed aggregate. The example also releases the perturbed aggregate from the secure enclave.

Abstract: Various technologies pertaining to authenticating a password in a manner that prevents offline dictionary attacks are described. A protected module, which can be a hardware security module, a trusted platform module, or the like, is in communication with an authentication server. The protected module comprises a key that is restricted to the protected module. The key is employed in connection with authenticating the password on the protected module.

Abstract: Various technologies pertaining to authenticating a password in a manner that prevents offline dictionary attacks are described. A protected module, which can be a hardware security module, a trusted platform module, or the like, is in communication with an authentication server. The protected module comprises a key that is restricted to the protected module. The key is employed in connection with authenticating the password on the protected module.

Abstract: Various technologies pertaining to authenticating a password in a manner that prevents offline dictionary attacks are described. A protected module, which can be a hardware security module, a trusted platform module, or the like, is in communication with an authentication server. The protected module comprises a key that is restricted to the protected module. The key is employed in connection with authenticating the password on the protected module.

Abstract: Described is a technology by which the identity of a person (e.g., a customer in a commercial transaction) is determinable without active identification effort, via biometric data is obtained without action by the person. Machine processing of the biometric data over a set of possible persons, determined from secondary proximity sensing, is used to determine or assist in determining the identity of the person.

Abstract: Described is a technology by which the identity of a person (e.g., a customer in a commercial transaction) is determinable without active identification effort, via biometric data is obtained without action by the person. Machine processing of the biometric data over a set of possible persons, determined from secondary proximity sensing, is used to determine or assist in determining the identity of the person.

Abstract: Described is a technology by which the identity of a person (e.g., a customer in a commercial transaction) is determinable without active identification effort, via biometric data is obtained without action by the person. Machine processing of the biometric data over a set of possible persons, determined from secondary proximity sensing, is used to determine or assist in determining the identity of the person.

Abstract: Various technologies pertaining to authenticating a password in a manner that prevents offline dictionary attacks are described. A protected module, which can be a hardware security module, a trusted platform module, or the like, is in communication with an authentication server. The protected module comprises a key that is restricted to the protected module. The key is employed in connection with authenticating the password on the protected module.

Abstract: In the operation of the present invention, a compacted porous medium is provided with a supply of the desired liquid and is subjected to centrifugal force until the measurement of the flow rate of liquid through the medium is substantially constant. The apparatus comprises: the porous medium in a container and an arrangement of reservoirs which supply liquid to the medium and collect liquid coming out of the medium while maintaining constant pressures at the inflow and outflow ends of the medium. The use of this invention entails measurements of the flow rate of liquid through the medium and conditions of liquid in the medium for the purpose of determine the liquid conductivity.