Patents by Inventor Jacob S. Applebaum

Jacob S. Applebaum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified proteins and methods of use thereof
    Patent number: 11155580
    Abstract: This invention is generally related to small proteins, such as miniature proteins, including avian pancreatic polypeptide (aPP), modified so that the small proteins reach the cytosol. In some embodiments, the modified protein molecules deliver an associated cargo molecule to the cytosol. Other embodiments of the invention relate to modified protein fusion molecules that reach the cytosol.
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: October 26, 2021
    Assignee: Yale University
    Inventors: Alanna Schepartz Shrader, Jacob S. Applebaum, Jonathan R. LaRochelle
  • Modified Proteins and Methods of Use Thereof
    Publication number: 20190211062
    Abstract: This invention is generally related to small proteins, such as miniature proteins, including avian pancreatic polypeptide (aPP), modified so that the small proteins reach the cytosol. In some embodiments, the modified protein molecules deliver an associated cargo molecule to the cytosol. Other embodiments of the invention relate to modified protein fusion molecules that reach the cytosol.
    Type: Application
    Filed: January 17, 2019
    Publication date: July 11, 2019
    Inventors: Alanna S. Schepartz, Jacob S. Applebaum, Jonathan R. LaRochelle
  • Modified proteins and methods of use thereof
    Patent number: 10227384
    Abstract: This invention is generally related to small proteins, such as miniature proteins, including avian pancreatic polypeptide (aPP), modified so that the small proteins reach the cytosol. In some embodiments, the modified protein molecules deliver an associated cargo molecule to the cytosol. Other embodiments of the invention relate to modified protein fusion molecules that reach the cytosol.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: March 12, 2019
    Assignee: YALE UNIVERSITY
    Inventors: Alanna S. Schepartz, Jacob S. Applebaum, Jonathan R. LaRochelle
  • Modified Proteins and Methods of Use Thereof
    Publication number: 20160068574
    Abstract: This invention is generally related to small proteins, such as miniature proteins, including avian pancreatic polypeptide (aPP), modified so that the small proteins reach the cytosol. In some embodiments, the modified protein molecules deliver an associated cargo molecule to the cytosol. Other embodiments of the invention relate to modified protein fusion molecules that reach the cytosol.
    Type: Application
    Filed: April 14, 2014
    Publication date: March 10, 2016
    Inventors: Alanna S. Schepartz, Jacob S. Applebaum, Jonathan R. LaRochelle