Abstract: A shared storage system that is optimized for post-production workflows that use NLEs such as Final Cut Pro X, DaVinci Resolve, Premiere and Avid is disclosed. Further, shared storage systems comprising workstations and shared storage systems, such as NAS devices, are disclosed that optimize workstation settings based on a database of optimal configuration settings to provide optimal bandwidth, minimal latency and stable performance for digital content creation/editing workflows that use file exchange between the workstation and the shared storage system. Novel methods and systems for storage systems are disclosed that configure and expose share drives in novel ways to facilitate video editing, audio editing and compositing.

Abstract: Methods and compositions for inducing cell death in cells with FET-fused oncogenes, as well as methods for treating tumors with FET-fused oncogenes, such as cells and tumors associated with Ewing's sarcoma and fibromyxoid Iposarcoma. Oncogenes may include the EWS-FLI1 oncogene, FUS-FLI1 oncogene, FUS-CHOP oncogene, etc. The methods feature herein administering to a patient with a FET-fused oncogene tumor a combination of a DNA damaging agent and a transcription inhibitor. The combination of the transcription inhibitor and DNA damaging agent causes death of cells in the tumor.

Abstract: A shared storage system that is optimized for post-production workflows that use NLEs such as Final Cut Pro X, DaVinci Resolve, Premiere and Avid is disclosed. Further, shared storage systems comprising workstations and shared storage systems, such as NAS devices, are disclosed that optimize workstation settings based on a database of optimal configuration settings to provide optimal bandwidth, minimal latency and stable performance for digital content creation/editing workflows that use file exchange between the workstation and the shared storage system. Novel methods and systems for storage systems are disclosed that configure and expose share drives in novel ways to facilitate video editing, audio editing and compositing.

Abstract: A shared storage system that is optimized for post-production workflows that use NLEs such as Final Cut Pro X, DaVinci Resolve, Premiere and Avid is disclosed. Further, shared storage systems comprising workstations and shared storage systems, such as NAS devices, are disclosed that optimize workstation settings based on a database of optimal configuration settings to provide optimal bandwidth, minimal latency and stable performance for digital content creation/editing workflows that use file exchange between the workstation and the shared storage system. Novel methods and systems for storage systems are disclosed that configure and expose share drives in novel ways to facilitate video editing, audio editing and compo siting.

Abstract: Intelligent application notification management is provided. A state machine on a communication device is used to retain, sequence, and handle notifications included in a notification queue. It is determined whether a new notification has been received and whether the new notification can be added to a notification queue based on a maximum number of notifications. It may be determined whether the new notification is a duplicate of an existing notification in the notification queue. Notifications in the queue may be combined, reordered, and altered. The notification queue may be modified based on one or more of the following: an attribute, user input, user preference, a system state, or whether an application to which the notification is related is currently active. The notification management system may therefore decide which of the notifications to display and when to display them, such that notifications are presented logically and a user is not overwhelmed.

Abstract: Methods, systems, and compositions for detecting molecule aggregation, folding, or interactions featuring comparing the amount of labeling of a molecule of interest, such as a protein, in a test sample with an amount of labeling in a control, e.g., a sample wherein the molecule of interest is denatured. If less labeling is present in the test sample as compared to the control sample, the test sample may comprise the molecule of interest in aggregate form, folded form, or interactive form, e.g., interacting with another molecule such as a protein molecule, DNA molecule or RNA molecule. The present invention may be used for detecting or monitoring a disease or condition such as a protein misfolding disease (proteopathy), e.g., amyotrophic lateral sclerosis (ALS), etc.

Abstract: Methods, systems, and compositions for detecting molecule aggregation, folding, or interactions featuring comparing the amount of labeling of a molecule of interest, such as a protein, in a test sample with an amount of labeling in a control, e.g., a sample wherein the molecule of interest is denatured. If less labeling is present in the test sample as compared to the control sample, the test sample may comprise the molecule of interest in aggregate form, folded form, or interactive form, e.g., interacting with another molecule such as a protein molecule, DNA molecule or RNA molecule. The present invention may be used for detecting or monitoring a disease or condition such as a protein misfolding disease (proteopathy), e.g., amyotrophic lateral sclerosis (ALS), etc.

Abstract: A liquid metal leak detector system including a direct current (DC) power supply and a plurality of analog to digital converters connected to the DC power supply. Each converter includes a liquid metal switch, where the liquid metal switch is closed in event of a liquid metal leak since the liquid metal leak causes electrical continuity between a conductive sheeting and a housing for liquid metal. The converter also includes a comparator connected to both the liquid metal switch for converting an analog signal into a digital signal, wherein the digital signal is configured such that a high signal constitutes no leak and a low signal constitutes a leak. An AND gate is also connected to each of the plurality of converters for combining all of the digital signals output from the converters, the AND gate configured such that the AND gate outputs a high signal if all of its inputs are high and a low signal if any input is low.

Abstract: Methods, systems, and compositions for detecting molecule aggregation, folding, or interactions featuring comparing the amount of labeling of a molecule of interest, such as a protein, in a test sample with an amount of labeling in a control, e.g., a sample wherein the molecule of interest is denatured. If less labeling is present in the test sample as compared to the control sample, the test sample may comprise the molecule of interest in aggregate form, folded form, or interactive form, e.g., interacting with another molecule such as a protein molecule, DNA molecule or RNA molecule. The present invention may be used for detecting or monitoring a disease or condition such as a protein misfolding disease (proteopathy), e.g., amyotrophic lateral sclerosis (ALS), etc.

Abstract: Intelligent application notification management is provided. A state machine on a communication device is used to retain, sequence, and handle notifications included in a notification queue. It is determined whether a new notification has been received and whether the new notification can be added to a notification queue based on a maximum number of notifications. It may be determined whether the new notification is a duplicate of an existing notification in the notification queue. Notifications in the queue may be combined, reordered, and altered. The notification queue may be modified based on one or more of the following: an attribute, user input, user preference, a system state, or whether an application to which the notification is related is currently active. The notification management system may therefore decide which of the notifications to display and when to display them, such that notifications are presented logically and a user is not overwhelmed.

Abstract: A liquid metal leak detector system including a direct current (DC) power supply and a plurality of analog to digital converters connected to the DC power supply. Each converter includes a liquid metal switch, where the liquid metal switch is closed in event of a liquid metal leak since the liquid metal leak causes electrical continuity between a conductive sheeting and a housing for liquid metal. The converter also includes a comparator connected to both the liquid metal switch for converting an analog signal into a digital signal, wherein the digital signal is configured such that a high signal constitutes no leak and a low signal constitutes a leak. An AND gate is also connected to each of the plurality of converters for combining all of the digital signals output from the converters, the AND gate configured such that the AND gate outputs a high signal if all of its inputs are high and a low signal if any input is low.

Abstract: One aspect of the present disclosure relates to a system that can provide training for an operating room staff member. The system can include a hand device with a housing that can be configured to receive an input of a device from the operating room staff member. Inside the housing, the hand device can include a non-transitory memory that stores instructions and a processor that can be configured to execute the instructions to at least: provide an instruction related to placing a surgical instrument in the hand device to the operating room staff member; receive a test surgical instrument from the operating room staff member in response to the instruction; and determine whether the test surgical instrument matches the instructed surgical instrument.

Abstract: Compounds having the formula (I) wherein R1, R2, R3 and Ar as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.

Abstract: Compounds having the formula I wherein Z, Z1 Z2 Z, R3a, R3b and Rb and as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.

Abstract: The present invention provides a method for organizing genomic information from multiple organisms. In one embodiment of the invention, phylogenetic trees can be constructed for the organisms. The method of the present invention is termed CAPO, Comparative Analysis and Phylogeny with Optical-Maps. Optical maps of organisms are obtained and phylogeny between the organisms is determined by optical map comparison and bipartite graph matching between the organisms, as, for example, computed by a stable marriage algorithm.

Abstract: The present invention provides a method for organizing genomic information from multiple organisms. In one embodiment of the invention, phylogenetic trees can be constructed for the organisms. The method of the present invention is termed CAPO, Comparative Analysis and Phylogeny with Optical-Maps. Optical maps of organisms are obtained and phylogeny between the organisms is determined by optical map comparison and bipartite graph matching between the organisms, as, for example, computed by a stable marriage algorithm.

Abstract: Ligand-responsive chimeric proteins are engineered to cause a detectable output in response to a preselected stimulus. The engineered chimeric proteins are useful in industrial, commercial, medical, and scientific fields as a tool for programming a cellular response to a stimulus of choice and for use with in vitro assays. The engineered chimeric proteins include a detection domain and an interaction domain. Interaction of the engineered chimeric protein with a target biomolecule is modulated by the presence or absence of the preselected stimulus.

Abstract: The present invention provides Modular Molecular Clasps and methods of using these Modular Molecular Clasps in a wide range of applications in the health care industry, e.g., in therapy, in clinical diagnostics, in in vivo imaging or in drug discovery. The Modular Molecular Clasps of the present invention also have industrial and environmental applications, e.g., in environmental diagnostics, industrial diagnostics, food safety, toxicology, catalysis of reactions or high-throughput screening; as well as applications in the agricultural industry and in basic research. Methods of designing the Modular Molecular Clasps, as well as arrays and biosensors comprising these Modular Molecular Clasps are also provided.

Abstract: A computer user interface that represents information stored in a computer as reprentation objects located on at least one reference surface is disclosed. A user can magnify or reduce the displayed information by "zooming" in or out. The magnification operation displays a smaller portion of a particular surface, but each object that remains in view is displayed in greater size and/or detail. Similarly, the reduction operation displays a larger portion of a given surface, but each object within such surface is displayed in a smaller size and/or less detail. In order to view one part of the surface from another part of the surface or from another surface, a special type of an object, called a representation portal object, is provided. A graphical description of each object is physically stored in computer memory essentially as a sequence of compressed image representations.

Abstract: An optical radar is disclosed in which fine vernier range and angular displacement accuracy is achieved by projecting a burst of coherent pulses so as to strobe a target passing through the field of view of the projection apparatus. The use of the pulse burst permits the most recent information to be utilized in obtaining the target track. Prior to projection, the pulses in the burst are sampled. The resulting signal is delayed by an amount corresponding to course range and is directed down one of a pair of oppositely directed delay lines. The signals returned from the target are detected by a sectorized receiver, with an electrical output signal from a detector in one of the sectors being applied to the other delay line in the corresponding pair, such that the signal corresponding to the returned pulse propagates in a direction opposite to that of the sampled signal corresponding to the transmitted pulse.