Patents by Inventor JACOB SOLEY

JACOB SOLEY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROCYCLIC INHIBITORS OF IGF-1R AND USES THEREOF
    Publication number: 20260199302
    Abstract: Disclosed herein are compounds useful for the inhibition of insulin-like growth factor 1 receptor (IGF-1R). The compounds have a general Formula (I): or pharmaceutically acceptable salts thereof, wherein the variables of Formula (I) are as defined herein. Also provided herein are pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, thyroid-associated ophthalmopathy, Graves' opthalmopathy or Graves' orbitopathy. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).
    Type: Application
    Filed: January 12, 2026
    Publication date: July 16, 2026
    Applicant: AMGEN INC.
    Inventors: Ashley FENWICK, Marta E. WENZLER, Denis BILLEN, Yeeman K. RAMTOHUL, William BROWN, Thomas PINTER, Thomas JOHNSON, Jacob SOLEY, Ken Loon CHOO, Nicholas Willet Mitchell MICHEL, Naresh VEMULA, Sacha NGUYEN, Geoffrey S. SINCLAIR, Vincent ALBERT
  • HETEROCYCLIC INHIBITORS OF IGF-1R FOR TREATMENT OF DISEASE
    Publication number: 20250171431
    Abstract: The present invention relates to polycyclic heterocyclic compounds and methods which may be useful as inhibitors of IGF-1R for the treatment or prevention of thyroid eye disease (TED), also known as thyroid-associated ophthalmopathy (TAO), or Graves' ophthalmopathy or orbitopathy (GO).
    Type: Application
    Filed: August 2, 2024
    Publication date: May 29, 2025
    Inventors: ASHLEY FENWICK, MARTA E. WENZLER, DENIS BILLEN, YEEMAN K. RAMTOHUL, WILLIAM BROWN, NARESH VEMULA, NICHOLAS WILLET MICHEL, THOMAS JOHNSON, JACOB SOLEY, GEOFFREY S. SINCLAIR, KEN LOON CHOO, Yuki Maekawa, TABINDA AHMAD
  • HETEROCYCLIC INHIBITORS OF IGF-1R FOR TREATMENT OF DISEASE
    Publication number: 20250145585
    Abstract: The present invention relates to heterocyclic compounds, pharmaceutical compositions thereof, and methods which may be useful as inhibitors of IGF-1R for the treatment or prevention of thyroid eye disease (TED), also known as thyroid-associated ophthalmopathy (TAO), or Graves' ophthalmopathy or orbitopathy (GO).
    Type: Application
    Filed: July 18, 2024
    Publication date: May 8, 2025
    Inventors: ASHLEY FENWICK, MARTA E. WENZLER, DENIS BILLEN, YEEMAN K. RAMTOHUL, WILLIAM BROWN, NARESH VEMULA, FRANCIS BARABE, THOMAS PINTER, NICHOLAS WILLET MITCHELL MICHEL, THOMAS JOHNSON, JACOB SOLEY, GEOFFREY S. SINCLAIR, KEN LOON CHOO