Patents by Inventor Jacob T. Shelley

Jacob T. Shelley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11133170
    Abstract: A solution-cathode glow discharge mass spectrometry (SCGD-MS) apparatus comprises a SCGD source and a mass spectrometer. The SCGD source may comprise conductive rods, a power source, and a capillary. A method for ionizing an analyte comprises flowing an electrically conductive liquid onto a conductive rod, applying an electric potential to a second conductive rod such that a plasma discharge forms between the first conductive rod and the electrically conductive liquid to produce ions, and separating the ions in a mass spectrometer. The analyte may be a polypeptide that may be contacted with trypsin. The analyte may be a solid, liquid, gas, chemical complex, or ion in solution. The method may comprise sequencing the polypeptide.
    Type: Grant
    Filed: August 19, 2020
    Date of Patent: September 28, 2021
    Assignees: Indiana University Research and Technology Corporation, Kent State University
    Inventors: Jacob T. Shelley, Kelsey L. Williams, Gary M. Hieftje, Andrew J. Schwartz
  • Publication number: 20210098245
    Abstract: A solution-cathode glow discharge mass spectrometry (SCGD-MS) apparatus comprises a SCGD source and a mass spectrometer. The SCGD source may comprise conductive rods, a power source, and a capillary. A method for ionizing an analyte comprises flowing an electrically conductive liquid onto a conductive rod, applying an electric potential to a second conductive rod such that a plasma discharge forms between the first conductive rod and the electrically conductive liquid to produce ions, and separating the ions in a mass spectrometer. The analyte may be a polypeptide that may be contacted with trypsin. The analyte may be a solid, liquid, gas, chemical complex, or ion in solution. The method may comprise sequencing the polypeptide.
    Type: Application
    Filed: August 19, 2020
    Publication date: April 1, 2021
    Inventors: Jacob T. Shelley, Kelsey L. Williams, Gary M. Hieftje, Andrew J. Schwartz
  • Patent number: 10784097
    Abstract: A solution-cathode glow discharge (SCGD) spectrometry apparatus may comprise an SCGD source and a mass or ion mobility spectrometer. A method for ionizing a molecular analyte may comprise contacting the molecular analyte with a plasma discharge to form ions and separating the ions in a mass spectrometer or ion mobility spectrometer. The contacting step may occur under atmospheric pressure and/or ambient conditions. The molecular analyte may be fragmented by the plasma discharge.
    Type: Grant
    Filed: August 28, 2016
    Date of Patent: September 22, 2020
    Assignees: Indiana University Research And Technology Corporation, Kent State University
    Inventors: Jacob T. Shelley, Kelsey L. Williams, Gary M. Hieftje, Andrew J. Schwartz
  • Publication number: 20180247804
    Abstract: A solution-cathode glow discharge (SCGD) spectrometry apparatus may comprise an SCGD source and a mass or ion mobility spectrometer. A method for ionizing a molecular analyte may comprise contacting the molecular analyte with a plasma discharge to form ions and separating the ions in a mass spectrometer or ion mobility spectrometer. The contacting step may occur under atmospheric pressure and/or ambient conditions. The molecular analyte may be fragmented by the plasma discharge.
    Type: Application
    Filed: August 28, 2016
    Publication date: August 30, 2018
    Inventors: Jacob T. SHELLEY, Kelsey L. WILLIAMS, Gary M. Hieftje, Andrew J. SCHWARTZ
  • Patent number: 9607306
    Abstract: A method and apparatus for identification of a counterfeit electronic component, subjecting a suspected counterfeit electronic to an analytical method of ambient surface analysis to desorb and ionize compounds directly from a suspected counterfeit electronic surface with no pretreatment, detecting the resultant ions, comparing the identified ions to known standards, and returning a confidence that the suspected counterfeit electronic being analyzed is counterfeit.
    Type: Grant
    Filed: March 18, 2015
    Date of Patent: March 28, 2017
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Gary M. Hieftje, Steven J. Ray, Kevin P. Pfeuffer, Jacob T. Shelley, Norris J. Caldwell
  • Publication number: 20150269592
    Abstract: A method and apparatus for identification of a counterfeit electronic component, subjecting a suspected counterfeit electronic to an analytical method of ambient surface analysis to desorb and ionize compounds directly from a suspected counterfeit electronic surface with no pretreatment, detecting the resultant ions, comparing the identified ions to known standards, and returning a confidence that the suspected counterfeit electronic being analyzed is counterfeit.
    Type: Application
    Filed: March 18, 2015
    Publication date: September 24, 2015
    Inventors: Gary M. HIEFTJE, Steven J. RAY, Kevin P. PFEUFFER, Jacob T. SHELLEY, Norris J. CALDWELL
  • Patent number: 8207494
    Abstract: Disclosed is an apparatus for performing mass spectrometry and a method of analyzing a sample through mass spectrometry. In particular, the disclosure relates to an apparatus capable of ambient mass spectrometry and mass spectral imaging and a method for the same. The apparatus couples laser ablation, flowing atmospheric-pressure afterglow ionization, and a mass spectrometer.
    Type: Grant
    Filed: May 1, 2009
    Date of Patent: June 26, 2012
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Gary M. Hieftje, Francisco J. Andrade, Steven J. Ray, Jacob T. Shelley
  • Patent number: 7893408
    Abstract: A method for ionizing and desorbing a sample for analysis includes energizing a first and second electrode to produce a glow discharge at atmospheric pressure. The method further includes supplying a carrier gas to at least a portion of the glow discharge to create effluents thereof. The method further includes conducting the effluents of the glow discharge to the sample to ionize and desorb the sample for analysis. An associated apparatus is also disclosed.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: February 22, 2011
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Gary M. Hieftje, Steven J. Ray, Francisco J. Andrade, William C. Wetzel, Michael R. Webb, Gerardo Gamez, Jacob T. Shelley
  • Publication number: 20090272893
    Abstract: Disclosed is an apparatus for performing mass spectrometry and a method of analyzing a sample through mass spectrometry. In particular, the disclosure relates to an apparatus capable of ambient mass spectrometry and mass spectral imaging and a method for the same. The apparatus couples laser ablation, flowing atmospheric-pressure afterglow ionization, and a mass spectrometer.
    Type: Application
    Filed: May 1, 2009
    Publication date: November 5, 2009
    Inventors: Gary M. Hieftje, Francisco J. Andrade, Steven J. Ray, Jacob T. Shelley