Patents by Inventor Jacob Visser
Jacob Visser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10415045Abstract: The present invention provides a new fungal production system comprising a fungal host strain of Chrysosporium lucknowense wherein the endogenous cellulase secretion is less than 20% of the endogenous cellulase secretion of Chrysosporium lucknowense strain UV 18-25. Preferably, also the secretion of endogenous protease, endogenous ?-glucanase and endogenous cellobiohydrolase is less than 20% of the secretion of Chrysosporium lucknowense strain UV 18-25. Furthermore, fungal host strains are provided wherein several genes have been disrupted. According to another aspect of the invention a method for homologous and/or heterologous production of a pure protein with a purity of higher than 75%, comprising expressing a gene encoding said protein in the strains according to the invention have been described. Furthermore, a method for production of artificial protein mixes comprising expressing a gene encoding each of said proteins in a strain according to the invention have been disclosed.Type: GrantFiled: September 9, 2015Date of Patent: September 17, 2019Assignee: DANISCO US INCInventors: Peter J. Punt, Richard Paul Burlingame, Christine M. Pynnonen, Phillip T. Olson, Jan Wery, Johannes Heinrich Visser, Mark A. Emalfarb, Jacob Visser, Jan Cornelis Verdoes
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Patent number: 10266863Abstract: The present invention is in the area of enzymes for (hemi-)cellulose degradation and/or modification, more in particular the degradation and/or modification of xylan. The invention is based on a newly discovered enzymatic activity of a class of lytic polysaccharide monooxygenases (LPMOs), i.e. oxidative cleavage of xylan in addition to oxidative cleavage of cellulose. The present invention therefore relates to a method for degrading and/or modifying xylan in a xylan-comprising substrate, a method for preparing a product from a xylan-comprising substrate, a kit of parts, a liquid, paste or solid formulation, and a xylan-comprising composition, comprising said LPMO. The invention further relates to a use of said LPMO, said kit of parts, said formulation and/or said composition, in a method of the invention.Type: GrantFiled: March 11, 2016Date of Patent: April 23, 2019Assignee: Genencor International B.V.Inventors: Martijn Johannes Koetsier, Jacob Visser, Sandra Wilhelmina Agnes Hinz, Mirjam Anna Kabel, Matthias Frommhagen, Harm Gruppen
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Publication number: 20190002846Abstract: The present invention relates to fungal enzymes, more in particular of polyphenoloxidases (PPOs), and is based on a newly discovered enzymatic activity of a class of PPOs, i.e. de-methylation of R-substituted mono- or di-methoxyphenolsuch as present in lignin, lignin derived compounds and/or in lignocellulosic biomass. This newly discovered enzymatic activity renders these enzymes highly suitable for a plethora of applications in industry. Provided herein are methods of demethylation, processes to increase the reactivity of lignin or lignin-comprising biomass, processes of conversion lignin or lignin comprising biomass to value added products, processes for degrading and/or modifying (hemi-)cellulose in a hemicellulose-comprising substrate, and expression vectors, host cells and liquids, pastes or solid formulations and compositions for use in the demethylation method of the invention.Type: ApplicationFiled: June 24, 2016Publication date: January 3, 2019Inventors: Martijn Johannes Koetsier, Jacob Visser, Svetlana Laura Iancu, Mirjam Anna Kabel, Matthias Frommhagen, Harm Gruppen, Heiko Lange, Claudia Crestini, Bouchra Benjelloun-Mlayah
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Patent number: 10072267Abstract: Provided are cells having an increased protein production characterized in that said cell comprises modified SUMOylation, a process for producing such a cell or expression system and the use of such a cell in producing a protein of interest.Type: GrantFiled: February 22, 2017Date of Patent: September 11, 2018Assignee: DANISCO US INCInventors: Jurian Alexander Bronkhof, Jean-Paul Meijnen, Carola Bianca Michielse, Ismail Atalay Van Der Burgt, Jacob Visser, Johannes Heinrich Visser
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Publication number: 20180051305Abstract: The present invention is in the area of enzymes for (hemi-)cellulose degradation and/or modification, more in particular the degradation and/or modification of xylan. The invention is based on a newly discovered enzymatic activity of a class of lytic polysaccharide monooxygenases (LPMOs), i.e. oxidative cleavage of xylan in addition to oxidative cleavage of cellulose. The present invention therefore relates to a method for degrading and/or modifying xylan in a xylan-comprising substrate, a method for preparing a product from a xylan-comprising substrate, a kit of parts, a liquid, paste or solid formulation, and a xylan-comprising composition, comprising said LPMO. The invention further relates to a use of said LPMO, said kit of parts, said formulation and/or said composition, in a method of the invention.Type: ApplicationFiled: March 11, 2016Publication date: February 22, 2018Inventors: Martijn Johannes Koetsier, Jacob Visser, Sandra Wilhelmina Agnes Hinz, Mirjam Anna Kabel, Matthias Frommhagen, Harm Gruppen
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Publication number: 20170240909Abstract: Provided are cells having an increased protein production characterized in that said cell comprises modified SUMOylation, a process for producing such a cell or expression system and the use of such a cell in producing a protein of interest.Type: ApplicationFiled: February 22, 2017Publication date: August 24, 2017Inventors: JURIAN ALEXANDER BRONKHOF, JEAN-PAUL MEIJNEN, CAROLA BIANCA MICHIELSE, ISMAIL ATALAY VAN DER BURGT, JACOB VISSER, JOHANNES HEINRICH VISSER
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Publication number: 20150376629Abstract: The present invention provides a new fungal production system comprising a fungal host strain of Chrysosporium lucknowense wherein the endogenous cellulase secretion is less than 20% of the endogenous cellulase secretion of Chrysosporium lucknowense strain UV 18-25. Preferably, also the secretion of endogenous protease, endogenous ?-glucanase and endogenous cellobiohydrolase is less than 20% of the secretion of Chrysosporium lucknowense strain UV 18-25. Furthermore, fungal host strains are provided wherein several genes have been disrupted. According to another aspect of the invention a method for homologous and/or heterologous production of a pure protein with a purity of higher than 75%, comprising expressing a gene encoding said protein in the strains according to the invention have been described. Furthermore, a method for production of artificial protein mixes comprising expressing a gene encoding each of said proteins in a strain according to the invention have been disclosed.Type: ApplicationFiled: September 9, 2015Publication date: December 31, 2015Inventors: Peter J. PUNT, Richard Paul BURLINGAME, Christine M. PYNNONEN, Phillip T. OLSON, Jan WERY, Johannes Heinrich VISSER, Mark A. EMALFARB, Jacob VISSER, Jan Cornelis VERDOES, Jacoba VERDOES
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Patent number: 9175296Abstract: The present invention provides a new fungal production system comprising a fungal host strain of Chrysosporium lucknowense wherein the endogenous cellulase secretion is less than 20% of the endogenous cellulase secretion of Chrysosporium lucknowense strain UV 18-25. Preferably, also the secretion of endogenous protease, endogenous ?-glucanase and endogenous cellobiohydrolase is less than 20% of the secretion of Chrysosporium lucknowense strain UV 18-25. Furthermore, fungal host strains are provided wherein several genes have been disrupted. According to another aspect of the invention a method for homologous and/or heterologous production of a pure protein with a purity of higher than 75%, comprising expressing a gene encoding said protein in the strains according to the invention have been described. Furthermore, a method for production of artificial protein mixes comprising expressing a gene encoding each of said proteins in a strain according to the invention have been disclosed.Type: GrantFiled: March 16, 2010Date of Patent: November 3, 2015Assignee: DYADIC NEDERLAND B.V.Inventors: Peter J. Punt, Richard Paul Burlingame, Christine M. Pynnonen, Phillip T. Olson, Jan Wery, Johannes Heinrich Visser, Mark A. Emalfarb, Jacob Visser, Jan Cornelis Verdoes, Jacoba Verdoes
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Publication number: 20130280764Abstract: The present invention relates to modified filamentous fungal organisms having improved activity profiles with respect to the conversion of complex carbohydrates into simple sugars from cellulosic materials, including fungal organisms belonging to a genus selected from the group consisting of: Chrysosporium, Thielavia, Talaromyces, Thermomyces, Thermoascus, Neurospora, Aureobasidium, Filibasidium, Piromyces, Corynascus, Cryplococcus, Acremonium, Tolypocladium, Scytalidium, Schizophyllum, Sporotrichum, Penicillium, Gibberella, Myceliophthora, Mucor, Aspergillus, Fusarium, Humicola, Trichoderma, and Talaromyces, plus anamorphs and teleomorphs thereof.Type: ApplicationFiled: April 19, 2013Publication date: October 24, 2013Applicant: DYADIC INTERNATIONAL (USA) LTD.Inventors: Mark EMALFARB, Arkady SINITSYN, Richard JUNDZIL, Jan WERY, Jacob VISSER, Rob JOOSTEN, Martijn KOETSIER
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Patent number: 8461320Abstract: The subject invention lies in the field of microorganism mutation and selection of the mutants. In particular, the invention is directed at obtaining metabolic mutants in a simple, direct and specific manner. In a preferred embodiment it is also possible to obtain desired mutants not comprising recombinant DNA, thereby facilitating incorporation thereof in products for human consumption or application, due to shorter legislative procedures. The method according to the invention involves random mutation and specific selection of the desired metabolic mutant. Knockout, mutants wherein a gene associated with metabolism is absent or inactivated and mutants with increased or decreased DNA binding capacity are also claimed.Type: GrantFiled: April 22, 2003Date of Patent: June 11, 2013Assignee: DuPont Nutrition Biosciences ApSInventors: Leendert Hendrik De Graaff, Henriëtta Catharina Van Den Broeck, Jacob Visser
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Publication number: 20120295321Abstract: The invention relates to the production of biofuels, proteins, peptides and other value-added compounds from crude carbon sources. The inventors identified genes encoding novel pentose transporters, in particular transporters of L-arabinose and/or D-xylose. Regulation of the Aspergillus niger genes by xlnR and araR was instrumental in the identification of these genes and their substrate specificities. Provided are novel pentose transporters and their encoding nucleic acids. Also provided are host cells (over)expressing a transporter, and industrial applications thereof, for instance in biofuel production.Type: ApplicationFiled: November 12, 2010Publication date: November 22, 2012Applicants: Universiteit Utrecht Holding B.V., Universiteit Leiden, Stichting voor de Technische Wetenschappen, Vereniging voor christelijk hoger onderwijs, wetenschappelijk onderzoek en patientënzorgInventors: Patricia Ann vanKuyk, Ronald Peter de Vries, Jacob Visser, Arthur Franciscus Johannes Ram, Cornelis Antonius Maria Jacobus Johannes van den Hondel, Evy Battaglia, Diana Alexandra Vivas Duarte
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Publication number: 20120107856Abstract: The present invention provides a new fungal production system comprising a fungal host strain of Chrysosporium lucknowense wherein the endogenous cellulase secretion is less than 20% of the endogenous cellulase secretion of Chrysosporium lucknowense strain UV 18-25. Preferably, also the secretion of endogenous protease, endogenous ?-glucanase and endogenous cellobiohydrolase is less than 20% of the secretion of Chrysosporium lucknowense strain UV 18-25. Furthermore, fungal host strains are provided wherein several genes have been disrupted. According to another aspect of the invention a method for homologous and/or heterologous production of a pure protein with a purity of higher than 75%, comprising expressing a gene encoding said protein in the strains according to the invention have been described. Furthermore, a method for production of artificial protein mixes comprising expressing a gene encoding each of said proteins in a strain according to the invention have been disclosed.Type: ApplicationFiled: March 16, 2010Publication date: May 3, 2012Inventors: Peter J. Punt, Richard Paul Burlingame, Christine M. Pynnonen, Phillip T. Olson, Jan Wery, Johannes Heinrich Visser, Mark A. Emalfarb, Jacob Visser, Jan Cormelis Verdoes, Jacoba Verdoes
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Publication number: 20110287135Abstract: The invention relates to enzymes, compositions, and methods for efficient hydrolysis of arabinans present in plant biomass. More specifically, the invention relates to arabinases and compositions comprising arabinases to improve cell wall degradation to efficiently use plant biomass for bio-energy production. The invention also relates to a method for preparing a prebiotic. The prebiotic may contain branched arabinan oligomers comprise ?-(1,5)-linked arabinan backbone, and single substituted ?-(1,3)-linked arabinose monomers attached to the backbone, or double substituted ?-(1,2,3,5)-linked arabinose monomers attached to the backbone, or both. The invention also relates to a method for preparing fruit juice or wine. The invention also relates to a method for saccharification of a plant biomass. The invention also relates to a recombinant micro-organism genetically modified to express the enzymes of the present invention and optionally additional enzymes to achieve the disclosed methods.Type: ApplicationFiled: February 9, 2011Publication date: November 24, 2011Inventors: Stefan Kuehnel, Henk A. Schols, Yvonne Westphal, Sandra Hinz, Jacob Visser
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Patent number: 7078214Abstract: The present invention describes isolated polypeptides from fungi which have aminopeptidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.Type: GrantFiled: August 22, 2001Date of Patent: July 18, 2006Assignee: DSM IP Assets B.V.Inventors: Danielle Basten, Petrus Jacobus Theodorus Dekker, Paul William Schuurhuizen, Jacob Visser, Petrus Johannes Schaap
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Publication number: 20040038371Abstract: The present invention describes isolated polypeptides from fungi which have aminopeptidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.Type: ApplicationFiled: July 29, 2003Publication date: February 26, 2004Inventors: Danielle Basten, Petrus Jacobus Theodorus Dekker, Paul William Schuurhuizen, Jacob Visser, Petrus Johannes Schaap
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Publication number: 20040001904Abstract: Two cellobiohydrolase polypeptides (CBHA and CBHB) derived from Aspergillus are described and can be used to degrade cellulose. Variants of these peptides are described as well as DNA encoding the peptides, vectors and host cells. The peptides can be used to produce or process food, animal feed, wood pulp, paper and textiles.Type: ApplicationFiled: February 28, 2003Publication date: January 1, 2004Inventors: Marcus Matheus Catharina Gielkens, Jacob Visser, Leendert Hendrik De Graaff
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Publication number: 20030175893Abstract: The subject invention lies in the field of microorganism mutation and selection of the mutants. In particular the invention is directed at obtaining metabolic mutants in a simple, direct and specific manner. In a preferred embodiment it is also possible to obtain desired mutants not comprising recombinant DNA, thereby facilitating incorporation thereof in products for human consumption or application, due to shorter legislative procedures. The method according to the invention involves random mutation and specific selection of the desired metabolic mutant.Type: ApplicationFiled: April 22, 2003Publication date: September 18, 2003Applicant: DANSICO INGREDIENTS A/SInventors: Leendert Hendrik De Graaff, Henrietta Catharina Van Den Broeck, Jacob Visser
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Patent number: 6599745Abstract: The subject invention lies in the field of microorganism mutation and selection of the mutants. In particular, the invention is directed at obtaining metabolic mutants in a simple, direct and specific manner. In a preferred embodiment it is also possible to obtain desired mutants not comprising recombinant DNA, thereby facilitating incorporation thereof in products for human consumption or application, due to shorter legislative procedures. The method according to the invention involves random mutation and specific selection of the desired metabolic mutant. Knockout mutants wherein a gene associated with metabolism is absent or inactivated and mutants with increased or decreased DNA binding capacity are also claimed.Type: GrantFiled: July 11, 2000Date of Patent: July 29, 2003Assignee: Danisco Ingredients A/S (Danisco A/S)Inventors: Leendert Hendrik De Graaff, Henriëtta Catharina Van Den Broeck, Jacob Visser
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Patent number: 6558728Abstract: Recombinantly produced &agr;-glucuronidases which are useful in food manufacturing and as a feed additive to enhance the utilization of the feed components, and in other industrial applications such as pulp processing are provided. Genes coding for such enzymes can e.g. be isolated from Aspergillus sp. including A. tubigensis or A. niger.Type: GrantFiled: November 10, 1998Date of Patent: May 6, 2003Assignee: Danisco A/SInventors: Charlotte Horsmans Poulsen, Masoud R. Zargahi, Ronald Peter de Vries, Jacob Visser
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Patent number: 6558937Abstract: Two cellobiohydrolase polypeptides (CBHA and CBHB) derived from Aspergillus are described and can be used to degrade cellulose. Variants of these peptides are described as well as DNA encoding the peptides, vectors and host cells. The peptides can be used to produce or process food, animal feed, wood pulp, paper and textiles.Type: GrantFiled: April 4, 2000Date of Patent: May 6, 2003Assignee: DSM N.V.Inventors: Marcus Matheus Catharina Gielkens, Jacob Visser, Leendert Hendrik De Graaff