Abstract: A method may include illuminating a region of a choroid of an eye of a patient with off-axis illumination from a first imaging channel, the first imaging channel being off-axis with respect to an axis of a focus of the eye. The method may also include capturing an image of the choroid, where the off-axis illumination from the first imaging channel is off-set within the first imaging channel from the image sensor. A second off-axis illumination from a second imaging channel that is off-axis from both the first imaging channel and the off-axis illumination may illuminate the same or a different region of the choroid. The captured image of the choroid may be provided to a machine learning system. Indices associated with the image to may be identified based on an output of the machine learning system.