Abstract: The application relates to a sample holder (110) and a system (100). The application also relates to a method for processing a biological sample (S) and use of the sample holder or of the system in an analytical method or a diagnostic method. The sample holder (110) comprises a tubular member (111) with a wall that is at least locally transparent and at least locally permeable for reagents, wherein the tubular member consists at least partially of a transparent material.

Abstract: The invention relates to a filter unit (600), a method for manufacturing such a filter unit, and a cartridge (690) comprising such a filter unit. The filter unit (600) is characterized in that it comprises a filter material (601) which is integrated into the aperture of at least one foil (602, 603, 604). In a preferred embodiment, the filter material (601) may be located in the aperture of an intermediate foil (604) which is embedded between a top foil (602) and a bottom foil (603). Such a filter unit (600) can readily be produced in cost-effective processes like roll-to-roll manufacturing technologies.

Abstract: The invention relates to a system (1) for optically detecting at least one substance in a fluid (200). The system (1) comprises particles (400, 410) arranged to be dispersed in the fluid (200), each one comprising a magnetic bead (400) and an agent (410). The agent (410) is reactive with said substance such that it gives a specific optical response upon a determined optical excitation or a chemical reaction. The system (1) further comprises a chamber (330) to contain said fluid (200) and particles (400, 410). The chamber (330) is closed at one side by a window (310) optically transparent to the wavelengths of said optical response and said optical excitation. The system (1) further comprises an optical detector (100) adapted to detect at least a portion of said optical response. The system (1) further comprises magnetic sources (103) arranged to magnetically move the particles (400, 410) onto or close to the window (310).

Abstract: A cartridge for processing a fluid which features a fluid-treatment element that is permeable to at least a part of the fluid, and a processing chamber that is disposed adjacent to the fluid-treatment element. The treated fluid which passes the fluid-treatment element is processed in the processing chamber.

Abstract: A first output light beam (L2) that originates from a total internal reflection at a detection surface (111) of a total internal reflection TIR chamber (110) and a second output light beam (L2?) that comes from the interior of an inspectable chamber (120, 220, 320, 420, 520, 620) are both received within an observation region (OR). Preferably, these output light beams are detected with the same light detector, e.g. an image sensor (12). A total internal reflection at the TIR chamber and reflected light from inside the inspectable chamber are both directed to the same observation region (OR). This is for example enabled by different inclinations of the windows encountered by the first and the second output light beams, by different optical elements (407) in the paths of the output light beams, and/or by light scattering surface structures (122, 223, 322, 422, 522, 622) in the inspectable chamber.

Abstract: The present invention relates to a sensor cartridge (100) comprising: a sample depot (10) which is configured to store a liquid sample; a first cartridge portion (20) comprising a first measurement chamber (22) which is coupled to the sample depot (10) and configured to receive a quantity of the liquid sample from the sample depot (10), wherein the first cartridge portion (20) is configured to measure a first analyte using a first modality on the quantity of the liquid sample and to provide a first analyte test signal; a cartridge portion (30-1) comprising a second measurement chamber (32-1) which is coupled to the first measurement chamber (20), which is configured to receive the quantity of the liquid sample from the first measurement chamber (22), wherein the cartridge portion (30) is configured to measure a second analyte using a second modality on the quantity of the liquid sample and to provide a second analyte test signal.

Abstract: The invention relates to a detection apparatus (1) for detecting particles on or close to a particles detection surface (5) in a first optical detection mode and in a second optical detection mode, wherein a component of a light detection system (8) and/or a component of an optical system (9) of the detection apparatus is arranged to be used in the first detection mode and in the second detection mode. Since a component of the light detection system and/or a component of the optical system is arranged to be used in the first detection mode and in the second detection mode, this component does not need to be provided twice, i.e. for being used in the first detection mode and for being used in the second detection mode. This can lead to a reduced number of components and can make the detection apparatus technically less complex.

Abstract: The application relates to a sample holder (110) and a system (100). The application also relates to a method for processing a biological sample (S) and use of the sample holder or of the system in an analytical method or a diagnostic method. The sample holder (110) comprises a tubular member (111) with a wall that is at least locally transparent and at least locally permeable for reagents, wherein the tubular member consists at least partially of a transparent material.

Abstract: The invention relates to a cartridge (790) for processing a fluid comprising (i)a pre-treatment fluidic system with an inlet (710) via which the fluid can be supplied and at least one primary processing chamber (712) in which said fluid can be processed; (ii) a post-treatment fluidic system with at least one secondary processing chamber (755) in which fluid can be processed; (iii) a fluid-treatment element (701) that is permeable to at least a part oft he fluid and that couples the post-treatment fluidic system to the pre-treatment fluidic system. The fluid-treatment element may particularly be a filter material (701) integrated into at least one foil (702, 703, 704).

Abstract: The invention relates to a detection apparatus (1) for detecting particles on or close to a particles detection surface (5) in a first optical detection mode and in a second optical detection mode, wherein a component of a light detection system (8) and/or a component of an optical system (9) of the detection apparatus is arranged to be used in the first detection mode and in the second detection mode. Since a component of the light detection system and/or a component of the optical system is arranged to be used in the first detection mode and in the second detection mode, this component does not need to be provided twice, i.e. for being used in the first detection mode and for being used in the second detection mode. This can lead to a reduced number of components and can make the detection apparatus technically less complex.

Abstract: An apparatus for examination of a sample includes at least one sample chamber in which the sample can be provided, where the sample chamber has a detection surface; at least one light source for emitting a first input light beam which is totally internally reflected at the detection surface of the sample chamber into a first output light beam, and for emitting a second input light beam which is at least partially transmitted through the sample chamber into a second output light beam. The apparatus further includes at least one light detector for detecting the first and the second output light beams. The sample chamber is elongated and traversed in longitudinal direction by light of the second input light beam.

Abstract: The invention relates to an optical sensor device (100) that comprises a plurality of objectives (152) for generating primary images of corresponding sensor regions (111). The primary images are then mapped with intermediate optics (153) onto a detector plane (154), particularly onto the sensitive plane of an image sensor.

Abstract: A sensor device and a method for a double telecentric optical system includes a single focusing element, such as a lens. The device and method further include a mirror element arranged at a focal point of the single focusing element to reflect incoming light rays back to the single focusing element. The incoming and reflected light rays pass through different parts of the single focusing element to allow for a spatially separated arrangement of an object and its image.

Abstract: The invention relates to a filter unit (600), a method for manufacturing such a filter unit, and a cartridge (690) comprising such a filter unit. The filter unit (600) is characterized in that it comprises a filter material (601) which is integrated into the aperture of at least one foil (602, 603, 604). In a preferred embodiment, the filter material (601) may be located in the aperture of an intermediate foil (604) which is embedded between a top foil (602) and a bottom foil (603). Such a filter unit (600) can readily be produced in cost-effective processes like roll-to-roll manufacturing technologies.

Abstract: The invention relates to a cartridge (790) for processing a fluid comprising (i)a pre-treatment fluidic system with an inlet (710) via which the fluid can be supplied and at least one primary processing chamber (712) in which said fluid can be processed; (ii) a post-treatment fluidic system with at least one secondary processing chamber (755) in which fluid can be processed; (iii) a fluid-treatment element (701) that is permeable to at least a part oft he fluid and that couples the post-treatment fluidic system to the pre-treatment fluidic system. The fluid-treatment element may particularly be a filter material (701) integrated into at least one foil (702, 703, 704).

Abstract: The invention relates to a cartridge (890) for processing a fluid, comprising (i) a fluid-treatment element (801) that is permeable to at least a part of the fluid, and (ii) a processing chamber (855) that is disposed adjacent to the fluid-treatment element (801) and in which treated fluid that has passed said fluid-treatment element can be processed. The fluid-treatment element may particularly be a filter material (801) integrated into at least one foil (802, 803, 804).

Abstract: The invention relates to a cartridge (400), a sensor device, and a method for the optical examination of a sample. A first output light beam that originates from a total internal reflection at a detection surface of a TIR chamber and a second output light beam (L2?) that comes from the interior of an inspectable chamber (420) are both received within an observation region (OR). Preferably, these output light beams are detected with the same light detector, e.g. an image sensor. The invention hence allows for observing a total internal reflection at the TIR chamber and for looking into the inspectable chamber (420) from the same observation region (OR). This is for example enabled by different inclinations of the windows encountered by the first and the second output light beams, by different optical elements (407) in the paths of the output light beams, and/or by light scattering surface structures in the inspectable chamber.

Abstract: The invention relates to an optical sensor device (100) that comprises a plurality of objectives (152) for generating primary images of corresponding sensor regions (111). The primary images are then mapped with intermediate optics (153) onto a detector plane (154), particularly onto the sensitive plane of an image sensor.

Abstract: For irradiating a layer a radiation beam is directed and focussed to a spot on the layer, relative movement of the layer relative to the lens is caused so that, successively, different portions of the layer are irradiated and an interspace between a surface of the lens nearest to the layer is maintained. Furthermore, at least a portion of the interspace through which the radiation irradiates the spot on the layer is maintained filled with a liquid, the liquid being supplied via a supply conduit. At least a portion of the liquid fills up a recess through which the radiation irradiates the spot.

Abstract: For irradiating a layer a radiation beam is directed and focussed to a spot on the layer, relative movement of the layer relative to the lens is caused so that, successively, different portions of the layer are irradiated and an interspace between a surface of the lens nearest to the layer is maintained. Furthermore, at least a portion of the interspace through which the radiation irradiates the spot on the layer is maintained filled with a liquid, the liquid being supplied via a supply conduit. At least a portion of the liquid fills up a recess through which the radiation irradiates the spot.