Patents by Inventor Jacobus Johannes Van Dongen

Jacobus Johannes Van Dongen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acid amplification primers for pcr-based clonality studies
    Publication number: 20060234234
    Abstract: The invention relates to PCR-based clonality studies for among others early diagnosis of lymphoproliferative disorders. Provided is a set of nucleic acid amplification primers comprising a forward primer, or a variant thereof, and a reverse primer, or a variant thereof, capable of amplifying a rearrangement selected from the group consisting of a VH-JH IGH rearrangement, a DH-JH IGH rearrangement, a VK-JK IGK rearrangement, a VK/intron-Kde IGK rearrangement, a V?-J? IGL rearrangement, a V?-J? TCRB rearrangement, a D?-J? TCRB rearrangement, a V?-J? TCRG rearrangement, a V?-J? TCRD rearrangement, a D?-D? TCRD rearrangement, a D?-J? TCRD rearrangement, a V?-D? TCRD rearrangement, or a translocation selected from t(11; 14)(BCL1-IGH) and t(14;18)(BCL2-IGH). The primers can be used in PCR-based clonality studies for early diagnosis of lymphoproliferative disorders and detection of minimal residual disease (MRD). Also provided is a kit comprising at least one set of primers of the invention.
    Type: Application
    Filed: October 13, 2003
    Publication date: October 19, 2006
    Inventors: Jacobus Johannes Van Dongen, Eduardus Maria Schuuring, Jesus San Miquel, Ramon Garzia Sanz, Antonio Parreira, John Smith, Frances Lavender, Gareth Morgan, Paul Anthony Evans, Michael Kneba, Michael Hummel, Elizabeth Macintyre, Christian Bastard