Patents by Inventor Jacobus Maria Lemmens
Jacobus Maria Lemmens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20090326233Abstract: The invention relates to a compound, and pharmaceutically acceptable salts, having the formula I: wherein: R represents an alkyl or alkynyl group having 1-4 carbon atoms, or a phenyl group optionally substituted by C1-4 alkyl, alkylthio, alkoxy, halogen, nitro, acylamino, methylsulfonyl or methylenedioxy, or represents tetrahydronaphthyl, R1 represents hydrogen, trifluoro (C1-4) alkyl, alkyl or alkynyl, X represents hydrogen, alkyl having 1-4 carbon atoms, alkoxy, trifluoroalkyl, hydroxy, halogen, methylthio or aralkoxy, R2 represents: a C1-C10 alkyl group, a phenyl group optionally substituted by one or more of the following groups: a C1-C10 alkyl group, a halogen group, a nitro group, hydroxy group, and/or an alkoxy group.Type: ApplicationFiled: January 23, 2009Publication date: December 31, 2009Inventors: Franciscus Bernardus Gemm BENNEKER, Frans Van Dalen, Jacobus Maria Lemmens, Theodorus Hendricus Antonium Peters, Frantisek Picha
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Patent number: 7598271Abstract: The invention relates to a compound, and pharmaceutically acceptable salts, having the formula I: wherein: R represents an alkyl or alkynyl group having 1-4 carbon atoms, or a phenyl group optionally substituted by C1-4 alkyl, alkylthio, alkoxy, halogen, nitro, acylamino, methylsulfonyl or methylenedioxy, or represents tetrahydronaphthyl, R1 represents hydrogen, trifluoro (C1-4) alkyl, alkyl or alkynyl, X represents hydrogen, alkyl having 1-4 carbon atoms, alkoxy, trifluoroalkyl, hydroxy, halogen, methylthio or aralkoxy, R2 represents: a C1-C10 alkyl group, a phenyl group optionally substituted by one or more of the following groups: a C1-C10 alkyl group, a halogen group, a nitro group, hydroxy group, and/or an alkoxy group.Type: GrantFiled: November 30, 1998Date of Patent: October 6, 2009Assignee: Noven Therapeutics, LLCInventors: Franciscus Bernardus Gemma Benneker, Frans Van Dalen, Jacobus Maria Lemmens, Theodorus Hendricus Antonium Peters, Frantisek Picha
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Patent number: 6900327Abstract: The invention relates to a compound, and pharmaceutically acceptable salts, having the formula I: wherein: R represents an alkyl or alkynyl group having 1-4 carbon atoms, or a phenyl group optionally substituted by C1-4 alkyl, alkylthio, alkoxy, halogen, nitro, acylamino, methylsulfonyl or methylenedioxy, or represents tetrahydronaphthyl, R1 represents hydrogen, trifluoro (C1-4) alkyl, alkyl or alkynyl, X represents hydrogen, alkyl having 1-4 carbon atoms, alkoxy, trifluoroalkyl, hydroxy, halogen, methylthio or aralkoxy, R2 represents: a C1-C10 alkyl group, a phenyl group optionally substituted by one or more of the following groups: a C1-C10 alkyl group, a halogen group, a nitro group, hydroxy group, and/or an alkoxy group.Type: GrantFiled: May 16, 2001Date of Patent: May 31, 2005Assignee: Synthon BCT Technologies, LLCInventors: Franciscus Bernardus Gemma Benneker, Frans Van Dalen, Jacobus Maria Lemmens, Theodorus Hendricus Antonium Peters, Frantisek Picha
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Patent number: 6770761Abstract: A new process to obtain pramipexole and related products is described. The process involves the reaction of new compounds of formula (6), wherein R is hydrogen or acyl group, R3 and R4 are either the same and each of them represents an alkoxy group of 1-4 carbons or they together form a C2-C5 alkylenedioxy group or an oxo-group, with an alkylamine in the presence of a reducing agent or a hydrogen gas with hydrogenation catalyst. A process to obtain new compounds of formula (6) is also described.Type: GrantFiled: August 7, 2003Date of Patent: August 3, 2004Assignee: Synthon BVInventors: Karel Pospisilik, Hans Jan Hoorn, Theodorus Hendricus Antonius Peters, Jacobus Maria Lemmens
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Publication number: 20040086559Abstract: The invention is directed to novel and advantageous pharmaceutical compositions for oral administration of the antidepressant compound paroxetine. The composition is in the form of a tablet having a dissolution rate of at least 90% in 30 minutes measured with a paddle apparatus according to US Pharmacopoeia.Type: ApplicationFiled: December 23, 2003Publication date: May 6, 2004Inventors: Theodorus Hendricus Antonius Peters, Frans van Dalen, Jacobus Maria Lemmens, Frantisek Picha
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Publication number: 20040029936Abstract: A new process to obtain pramipexole and related products is described. The process involves the reaction of new compounds of formula (6), wherein R is hydrogen or acyl group, R3 and R4 are either the same and each of them represents an alkoxy group of 1-4 carbons or they together form a C2-C5 alkylenedioxy group or an oxo-group, with an alkylamine in the presence of a reducing agent or a hydrogen gas with hydrogenation catalyst. A process to obtain new compounds of formula (6) is also described.Type: ApplicationFiled: August 7, 2003Publication date: February 12, 2004Inventors: Karel Pospisilik, Hans Jan Hoorn, Theodorus Hendricus Antonius Peters, Jacobus Maria Lemmens
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Publication number: 20020035274Abstract: A process for the production of simvastatin and its analogues that is efficient, economical and convenient involves the use of hydroxyl protected intermediates of formula (III) or (VII). These intermediates allow for direct alkylation of the butyrate side chain followed by deprotection and reformation of the lactone ring.Type: ApplicationFiled: June 18, 2001Publication date: March 21, 2002Inventors: Frans Van Dalen, Jacobus Maria Lemmens, Gertruda Antonetta Philomina Van Helvoirt, Theororus Hendricus Antonius Peters, Frantisek Picha
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Publication number: 20010031767Abstract: The invention relates to a compound, and pharmaceutically acceptable salts, having the formula I: 1Type: ApplicationFiled: May 16, 2001Publication date: October 18, 2001Inventors: Franciscus Bernardus Gemma Benneker, Frans Van Dalen, Jacobus Maria Lemmens, Theodorus Hendricus Antonium Peters, Frantisek Picha
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Patent number: 6281360Abstract: Imidazopyridine compounds of the formula 1 are can be made in high purity, e.g. greater than 95% pure, by a process that use a novel intermediate of formula 5: wherein R1 and R2 each independently represent hydrogen or a lower alkyl group and Y and Z each independently represent a lower alkyl group. By this process, zolpidem, a commercial pharmaceutical of the formula 1 can be effectively made.Type: GrantFiled: February 25, 2000Date of Patent: August 28, 2001Assignee: Synthon BVInventors: Gerrit Jan Bouke Ettema, Jacobus Maria Lemmens, Theodorus Hendricus Antonius Peters, Frantisek Picha
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Patent number: 6271398Abstract: A process for the production of simvastatin and its analogues that is efficient, economical and convenient involves the use of hydroxyl protected intermediates of formula (III) or (VII). These intermediates allow for direct alkylation of the butyrate side chain followed by deprotection and reformation of the lactone ring. R1 is hydrogen or methyl; R2 represents a straight or branched chain alkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 3 to 7 carbon atoms, or an aralkyl group having 1 to 6 carbon atoms in the alkyl chain; R3 and R4 each independently represent an alkyl group, an ether group, a thioether group, an aryl group, an aralkyl group, an alkenyl group, a cyclic ether group, or a cyclic thioether group; and R5 and R6 each independently represent hydrogen, an alkyl group, an aryl group, an aralkyl group, an alkoxy group, or an ether group.Type: GrantFiled: June 19, 2000Date of Patent: August 7, 2001Assignee: Synthon BVInventors: Frans Van Dalen, Jacobus Maria Lemmens, Gertruda Antonetta Philomina Van Helvoirt, Theororus Hendricus Antonius Peters, Frantisek Picha
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Patent number: 6242460Abstract: Zolpidem salts having improved physical stability do not exhibit a melting endotherm corresponding to zolpidem free base when heated at 5° C./minute from about 25° C. to 250° C. The salts are generally easy to reproduce, even on an industrial scale and are easier to handle due to the increased stability than the known zolpidem tartrate. The zolpidem salts are typically pharmaceutically acceptable salts and can be used in formulating pharmaceutical compositions and in pharmaceutical uses; e.g. as a hypnotic.Type: GrantFiled: November 26, 1999Date of Patent: June 5, 2001Assignee: Synthon BVInventors: Gerrit Jan Bouke Ettema, Jacobus Maria Lemmens, Theodorus Hendricus Antonius Peters, Frantisek Picha
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Patent number: 5874447Abstract: The invention relates to a compound, and pharmaceutically acceptable salts, having the formula I: ##STR1## wherein: R represents an alkyl or alkynyl group having 1-4 carbon atoms, or a phenyl group optionally substituted by C.sub.1-4 alkyl, alkylthio, alkoxy, halogen, nitro, acylamino, methylsulfonyl or methylenedioxy, or represents tetrahydronaphthyl,R.sup.1 represents hydrogen, trifluoro (C.sub.1-4) alkyl, alkyl or alkynyl,X represents hydrogen, alkyl having 1-4 carbon atoms, alkoxy, trifluoroalkyl, hydroxy, halogen, methylthio or aralkoxy,R.sup.2 represents:a C1-C10 alkyl group,a phenyl group optionally substituted by one or more of the following groups:a C1-C10 alkyl group,a halogen group,a nitro group,hydroxy group,and/or an alkoxy group.Type: GrantFiled: June 10, 1997Date of Patent: February 23, 1999Assignee: Synthon B. V.Inventors: Franciscus Bernardus Gemma Benneker, Frans Van Dalen, Jacobus Maria Lemmens, Theodorus Hendricus Antonium Peters, Frantisek Picha