Patents by Inventor Jacque Banville

Jacque Banville has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alpha-substituted thio, -oxo trifluoromethylketones as phospholipase inhibitors
    Patent number: 6492550
    Abstract: Inhibitors of the cytosolic phospholypase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula where X, Z, X1, R1, R2, Ra and Rb are as defined in the specification.
    Type: Grant
    Filed: February 8, 2001
    Date of Patent: December 10, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jacques Banville, Serge Plamondon, Yonghua Gai, Neelakantan Balasubramanian
  • Alpha-and beta-substituted trifluoromethyl ketones as phospholipase inhibitors
    Patent number: 6414179
    Abstract: Inhibitors of the cytosolic phospholipase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula where X, Z, R1, R2, R3, R4, Ra and Rb are as defined in the specification.
    Type: Grant
    Filed: March 23, 2001
    Date of Patent: July 2, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jacques Banville, Anne Marinier, Yonghua Gai, Serge Plamondon, Stephan Roy, Neelakantan Balasubramanian
  • Alpha-substituted thio,-oxo trifluoromethylketones as phospholipase inhibitors
    Publication number: 20020068722
    Abstract: Inhibitors of the cytosolic phospholypase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases.
    Type: Application
    Filed: February 8, 2001
    Publication date: June 6, 2002
    Inventors: Jacques Banville, Serge Plamondon, Yonghua Gai, Neelakantan Balasubramanian
  • Alpha-and beta- substituted trifluoromethyl ketones as phospholipase inhibitors
    Publication number: 20020065246
    Abstract: Inhibitors of the cytosolic phospholipase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases.
    Type: Application
    Filed: March 23, 2001
    Publication date: May 30, 2002
    Inventors: Jacques Banville, Anne Marinier, Yonghua Gai, Serge Plamondon, Stephan Roy, Neelakantan Balasubramanian
  • Alpha-amino,-thio,-oxo substituted ketones as phospholipase inhibitors
    Publication number: 20020037875
    Abstract: Inhibitors of the cytosolic phospholypase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases.
    Type: Application
    Filed: May 3, 2001
    Publication date: March 28, 2002
    Inventors: Jacques Banville, Roger Remillard, Neelakantan Balasubramanian, Gilles Bouthillier, Alain Martel
  • Trifluoromethyl ketone analogs as selective cPLA2 inhibitors
    Patent number: 6350892
    Abstract: Selective inhibitors of the cPLA2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula where (R′), p, D, Y, Z, Ra, Rb and A are as defined in the specification.
    Type: Grant
    Filed: February 18, 2000
    Date of Patent: February 26, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jacques Banville, Yonghua Gai, Graham Johnson, Fred Christopher Zusi, James R. Burke
  • Trifluoromethyl ketone analogs as selective cPLA2 inhibitors
    Patent number: 6255496
    Abstract: Selective inhibitors of the cPLA2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases.
    Type: Grant
    Filed: April 27, 1999
    Date of Patent: July 3, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jacques Banville, Yonghua Gai, Graham Johnson, Fred Christopher Zusi, James R. Burke
  • Sulfated .alpha.-glycolipid derivatives as cell adhesion inhibitors
    Patent number: 5663151
    Abstract: There is provided novel sulfated .alpha.-glycolipid compounds of the formula ##STR1## wherein R is an acyl residue of a fatty acid;R.sup.1 is --(CH.dbd.CH).sub.m --(CH.sub.2).sub.n --CH.sub.3 ;R.sup.2, R.sup.3, R.sup.4and R.sup.6 are independently at least two --SO.sub.3 H;R.sup.2, R.sup.3, R.sup.4R.sup.5 and R.sup.6 each are independently hydrogen, unsubstituted or substituted alkanoyl, arylalkyl or arylcarbonyl wherein said substituent is selected from halogen, C.sub.1-4 alkyl, trifluoromethyl, hydroxy and C.sub.1-4 alkoxy;m is an integer of 0 or 1;n is an integer of from 5 to 14, inclusive;or a non-toxic pharmaceutically acceptable salt, solvate or hydrate thereof which are inhibitors of selectin-mediated cellular adhesion and are useful in the treatment or prevention of inflammatory diseases and other pathological conditions in mammals.
    Type: Grant
    Filed: January 27, 1995
    Date of Patent: September 2, 1997
    Assignee: Bristol-Myers Squibb Company
    Inventors: Alain Martel, Jacques Banville, Alejandro A. Aruffo
  • Sulfated .beta.-glycolipid derivatives as cell adhesion inhibitors
    Patent number: 5565433
    Abstract: There is provided novel sulfated p-glycolipid compounds of the formula ##STR1## wherein R is an acyl residue of a fatty acid;R.sup.1 is --(CH.dbd.CH).sub.m --(CH.sub.2).sub.n --CH.sub.3 ;R.sup.2, R.sup.3, R.sup.4 and R.sup.6 each are independently --SO.sub.3 H, hydrogen, unsubstituted or substituted alkanoyl, arylalkyl or arylcarbonyl wherein said substituent is selected from the group consisting of halogen, C.sub.1-4 alkyl, trifluoromethyl, hydroxy and C.sub.1-4 alkoxy; or R.sub.4 and R.sub.6, taken together are isopropylidene; provided at least two of R.sup.2, R.sup.3, R.sup.4 and R.sup.6 are --SO.sub.3 H;R.sup.5 is hydrogen, unsubstituted or substituted alkanoyl, arylalkyl or arylcarbonyl wherein said substituent is selected from the group consisting of halogen, C.sub.1-4 alkyl, trifluoromethyl, hydroxy and C.sub.
    Type: Grant
    Filed: February 12, 1996
    Date of Patent: October 15, 1996
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jacques Banville, Alain Martel, Alejandro A. Aruffo