Patents by Inventor Jacqueline Douglass

Jacqueline Douglass has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENGINEERED IMMUNE CELLS AND USES THEREOF
    Publication number: 20240148870
    Abstract: Provided herein are immune cells and methods of use, wherein the immune cells include a chimeric antigen receptor (CAR), wherein the CAR comprises an extracellular antigen binding domain that binds specifically to a first epitope; and an inhibitory chimeric antigen receptor (iCAR), wherein the iCAR comprises an extracellular antigen binding domain that binds specifically to a second epitope, wherein the immune cell is activated when the immune cells binds to the first epitope and does not bind to the second epitope; and wherein the immune cell is inactivated when the immune cell binds to the first and second epitopes.
    Type: Application
    Filed: March 11, 2022
    Publication date: May 9, 2024
    Inventors: Michael S. Hwang, Jacqueline Douglass, Emily Han-Chung Hsiue, Kenneth W. Kinzler, Brian J. Mog, Nickolas Papadopoulos, Alexander H. Pearlman, Bert Vogelstein, Shibin Zhou
  • METHODS AND MATERIALS FOR TREATING T CELL CANCERS
    Publication number: 20240002541
    Abstract: This document relates to methods and materials for treating T cell cancers. For example, a composition containing one or more bispecific molecules can be administered to a mammal having a T cell cancer to treat the mammal. For example, methods and materials for using one or more bispecific molecules to treat a mammal having a T cell cancer are provided.
    Type: Application
    Filed: December 1, 2021
    Publication date: January 4, 2024
    Inventors: Sarah DiNapoli, Jacqueline Douglass, Emily Han-Chung Hsiue, Michael S. Hwang, Kenneth W. Kinzler, Maximilian Konig, Brian J. Mog, Nickolas Papadopoulos, Andrew M. Pardoll, Suman Paul, Alexander H. Pearlman, Bert Vogelstein, Shibin Zhou
  • MANAbodies and methods of using
    Patent number: 11807662
    Abstract: This document provides methods and materials for assessing a mammal having or suspected of having cancer and/or for treating a mammal having cancer. For example, molecules including one or more antigen-binding domains (e.g., a single-chain variable fragment (scFv)) that can bind to a modified peptide (e.g., a tumor antigen), as well as method for using such molecules, are provided.
    Type: Grant
    Filed: May 16, 2018
    Date of Patent: November 7, 2023
    Assignee: The Johns Hopkins University
    Inventors: Emily Han-Chung Hsiue, Qing Wang, Bert Vogelstein, Kenneth W. Kinzler, Shibin Zhou, Jacqueline Douglass, Michael S. Hwang, Nickolas Papadopoulos
  • MANAbodies TARGETING TUMOR ANTIGENS AND METHODS OF USING
    Publication number: 20230051847
    Abstract: This document provides methods and materials for assessing a mammal having or suspected of having cancer and/or for treating a mammal having cancer. For example, molecules including one or more antigen-binding domains (e.g., a single-chain variable fragment (scFv)) that can bind to a modified peptide (e.g., a tumor antigen), as well as method for using such molecules, are provided.
    Type: Application
    Filed: December 17, 2020
    Publication date: February 16, 2023
    Inventors: Bert Vogelstein, Kenneth W. Kinzler, Emily Han-Chung Hsiue, Jacqueline Douglass, Michael S. Hwang, Alexander Pearlman, Nickolas Papadopoulos, Shibin Zhou, Brian Mog, Katharine M. Wright, Sandra B. Gabelli
  • MANAbodies AND METHODS OF USING
    Publication number: 20200079854
    Abstract: This document provides methods and materials for assessing a mammal having or suspected of having cancer and/or for treating a mammal having cancer. For example, molecules including one or more antigen-binding domains (e.g., a single-chain variable fragment (scFv)) that can bind to a modified peptide (e.g., a tumor antigen), as well as method for using such molecules, are provided.
    Type: Application
    Filed: May 16, 2018
    Publication date: March 12, 2020
    Inventors: Emily Han-Chung Hsiue, Qing Wang, Bert Vogelstein, Kenneth W. Kinzler, Shibin Zhou, Jacqueline Douglass, Michael S. Hwang, Nickolas Papadopoulos