Patents by Inventor Jacqueline F. Bromberg

Jacqueline F. Bromberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Constitutively active transcription factors and their uses for identifying modulators of activity including dysproliferative cellular changes
    Patent number: 6235873
    Abstract: The invention is directed to constitutively active Stat proteins and methods for their preparation. The modified Stat proteins have at least one cysteine residue which may interact with the corresponding cysteine residue on another modified Stat protein to form a dimer. The constitutively active Stat proteins are capable of binding to DNA and activating transcription in the absence of tyrosine phosphorylation. Cell lines expressing the modified Stat protein exhibit a transformed phenotype and are capable of forming tumors in nude mice. Methods are describe utilizing the modified Stat proteins of the invention in the absence and presence of tyrosine phosphorylation in identifying agents capable of modulating Stat protein dimerization, transcriptional activity, and cellular transformation in vitro and in vivo. The invention is also directed to polynucleotides encoding modified, constitutively active Stat proteins.
    Type: Grant
    Filed: July 31, 1999
    Date of Patent: May 22, 2001
    Assignee: The Rockefeller University
    Inventors: Jacqueline F. Bromberg, Melissa H. Wrzeszczynska, Yanxiang Zhao, James E. Darnell, Jr.