Patents by Inventor Jacqueline MacRitchie

Jacqueline MacRitchie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted pyrazinone derivatives for use in MCH-1 mediated diseases
    Patent number: 8329704
    Abstract: The present invention concerns aryl and heteroaryl substituted pyrazinone derivatives having antagonistic melanin-concentrating hormone (MCH) activity, in particular MCH-1 activity according to the general Formula (I) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, wherein the variables are defined in Claim 1. It further relates to their preparation, compositions comprising them and their use as a medicine. The compounds according to the invention are useful for the prevention and/or treatment of psychiatric disorders, including but not limited to anxiety, eating disorders, mood disorders, such as bipolar disorders and depression, psychoses, such as schizophrenia, and sleeping disorders; obesity; diabetes; sexual disorders and neurological disorders.
    Type: Grant
    Filed: December 18, 2006
    Date of Patent: December 11, 2012
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: José Ignacio Andrés-Gil, Manuel Jesús Alcázar-Vaca, Rosa María Álvarez-Escobar, Julen Oyarzabal Santamarina, Frank Matthias Dautzenberg, Jacqueline Macritchie, Donald Simpson, Sonia Martinez Gonzalez
  • TRIAZOLOPYRIDINE COMPOUNDS AND THEIR USE AS ASK INHIBITORS
    Publication number: 20120238565
    Abstract: The present invention relates to triazolopyridine compounds according to Formula (I), their use as medicament, for treating autoimmune disorders, inflammatory diseases, cardiovascular diseases and/or neurodegenerative diseases and a process for their preparation.
    Type: Application
    Filed: May 30, 2012
    Publication date: September 20, 2012
    Applicant: MERCK SERONO SA
    Inventors: DOMINIQUE SWINNEN, Catherine Jorand-Lebrun, Tania Grippi-Vallotton, Mathilde Muzerelle, Amanda Royle, Jacqueline Macritchie, Richard Hill, Jeffrey P. Shaw
  • Triazolopyridine compounds and their use as ask inhibitors
    Patent number: 8263595
    Abstract: The present invention relates to triazolopyridine compounds according to Formula (I), their use as medicament, for treating autoimmune disorders, inflammatory diseases, cardiovascular diseases and/or neurodegenerative diseases and a process for their preparation.
    Type: Grant
    Filed: August 20, 2008
    Date of Patent: September 11, 2012
    Assignee: Merck Serono SA
    Inventors: Dominique Swinnen, Catherine Jorand-Lebrun, Tania Grippi-Vallotton, Mathilde Muzerelle, Amanda Royle, Jacqueline MacRitchie, Richard Hill, Jeffrey P. Shaw
  • Tricyclic spiro derivatives as CRTH2 modulators
    Patent number: 8236963
    Abstract: The present invention is related to the use of spiro derivatives of Formula (I) for the treatment and/or prevention of allergic diseases, inflammatory dermatoses and other diseases with an inflammatory component. Specifically, the present invention is related to the use of spiro derivatives for the modulation of CRTH2 activity.
    Type: Grant
    Filed: May 23, 2006
    Date of Patent: August 7, 2012
    Assignee: Merck Serono SA
    Inventors: Matthias Schwarz, Eric Sebille, Christophe Cleva, Cedric Merlot, Dennis Church, Patrick Page, Jacqueline A. Macritchie, John Frederick Atherall, Stefano Crosignani, Doris Pupowicz
  • Triazolopyridine Compounds and Their Use as Ask Inhibitors
    Publication number: 20100197681
    Abstract: The present invention relates to triazolopyridine compounds according to Formula (I), their use as medicament, for treating autoimmune disorders, inflammatory diseases, cardiovascular diseases and/or neurodegenerative diseases and a process for their preparation.
    Type: Application
    Filed: August 20, 2008
    Publication date: August 5, 2010
    Applicant: Merck Serono SA
    Inventors: Dominique Swinnen, Catherine Jorand-Lebrun, Tania Grippi-Vallotton, Mathilde Muzerelle, Amanda Royle, Jacqueline MacRitchie, Richard Hill, Jeffrey P. Shaw
  • Tricyclic spiro derivatives as CRTH2 modulators
    Publication number: 20090318486
    Abstract: The present invention is related to the use of spiro derivatives of Formula (I) for the treatment and/or prevention of allergic diseases, inflammatory dermatoses and other diseases with an inflammatory component. Specifically, the present invention is related to the use of spiro derivatives for the modulation of CRTH2 activity.
    Type: Application
    Filed: May 23, 2006
    Publication date: December 24, 2009
    Applicant: Laboratoires Serono S.A.
    Inventors: Matthias Schwarz, Eric Sebille, Christophe Cleva, Cedric Merlot, Dennis Church, Patrick Page, Jacqueline A. Macritchie, John Frederick Atherall, Stefano Crosignani, Doris Pupowicz
  • Novel Substituted Pyrazinone Derivatives for Use in Mch-1 Mediated Diseases
    Publication number: 20090012062
    Abstract: The present invention concerns aryl and heteroaryl substituted pyrazinone derivatives having antagonistic melanin-concentrating hormone (MCH) activity, in particular MCH-1 activity according to the general Formula (I) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, wherein the variables are defined in Claim 1. It further relates to their preparation, compositions comprising them and their use as a medicine. The compounds according to the invention are useful for the prevention and/or treatment of psychiatric disorders, including but not limited to anxiety, eating disorders, mood disorders, such as bipolar disorders and depression, psychoses, such as schizophrenia, and sleeping disorders; obesity; diabetes; sexual disorders and neurological disorders.
    Type: Application
    Filed: December 18, 2006
    Publication date: January 8, 2009
    Inventors: Jose Ignacio Andres-Gil, Manuel Jesus Alcazar-Vaca, Rosa Maria Alvarez-Escobar, Julen Oyarzabal Santamarina, Frank Matthias Dautzenberg, Jacqueline Macritchie, Donald Simpson, Sonia Martinez Gonzalez
  • Piperazine Derivatives As Glyt 1 Inhibitors
    Publication number: 20080090822
    Abstract: The invention provides a compound of formula (I) or a salt or solvate thereof: wherein R1, n, X, Y and Z are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia.
    Type: Application
    Filed: March 9, 2006
    Publication date: April 17, 2008
    Inventors: Daniel Bradley, Clive Branch, Bethany Brown, Wai Chan, Steven Coulton, Martin Gilpin, Sharon Gough, Jacqueline MacRitchie, Howard Marshall, David Nash, Roderick Porter, Anthony Dean, Paul Doyle, Brian Evans, Luigi Stasi