Patents by Inventor Jacqueline Sagen

Jacqueline Sagen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preventing opiate tolerance by cellular implantation
    Patent number: 5762925
    Abstract: The use of CNS transplants, in particular adrenal medullary transplants, in reducing and/or preventing tolerance to opiates.
    Type: Grant
    Filed: November 3, 1994
    Date of Patent: June 9, 1998
    Inventor: Jacqueline Sagen
  • Reversing opiate tolerance by cellular implantation
    Patent number: 5730974
    Abstract: A method for reversing tolerance to opiates by implantation of adrenal medullary cells into the CNS is provided.
    Type: Grant
    Filed: October 23, 1996
    Date of Patent: March 24, 1998
    Assignee: Jacqueline Sagen
    Inventor: Jacqueline Sagen
  • Implantable cells that alleviate chronic pain in humans
    Patent number: 5656267
    Abstract: This invention provides a method of alleviating chronic pain in humans. Viable, implantable cells are selected which release neuroactive substances that reduce chronic pain. The cells are cultured to improve their viability, and administered into a region of the central nervous system of a patient who is suffering from chronic pain. The cells continue to secrete the neuroactive substances within the patient without exogenous stimulation. Suitable implantable cells include adrenal medullary tissue cells, chromaffin cells or genetically engineered cells.
    Type: Grant
    Filed: January 27, 1995
    Date of Patent: August 12, 1997
    Inventors: Jacqueline Sagen, George Demetrios Pappas
  • Method for alleviating depression
    Patent number: 4980174
    Abstract: A novel method for alleviating depression comprises implanting monoamine producing living cells in the CNS of depressive subjects.
    Type: Grant
    Filed: December 23, 1988
    Date of Patent: December 25, 1990
    Inventors: Jacqueline Sagen, Caryl E. Sortwell, George D. Pappas
  • Inducing analgesia by implantation of cells releasing neuroactive substances
    Patent number: 4753635
    Abstract: A method of inducing analgesia or reducing pain is described. The method involves implanting in the central nervous system of a host susceptible to pain, living material capable of releasing effective amount of analgesic substance when interacted with a stimulus which induces said material to release analgesic amount of said substance. The procedure described herein reduces sensitivity to intractable pain.
    Type: Grant
    Filed: May 23, 1986
    Date of Patent: June 28, 1988
    Inventors: Jacqueline Sagen, Mark Perlow, George D. Pappas, Harvey B. Pollard