Abstract: Provided herein are methods of treating a cancer in a patient wherein the patient has a KRAS G12C mutation, comprising administering to the patient a therapeutically effective combination of sotorasib and RMC-4630.

Abstract: The present disclosure relates to combinations of inhibitors of SOS1 and inhibitors of mTOR useful in the treatment of diseases or disorders.

Abstract: The present invention is directed to compositions and methods of treating or preventing diseases or disorders with inhibitors of SHP2, alone, and in combination with other therapeutic agents such as RAS pathway inhibitors (e.g., MEK inhibitors); methods of establishing appropriate treatment plans for subjects based upon the expression of one or more biomarker indicative of SHP2 inhibitor sensitivity; and methods of determining sensitivity to a SHP2 inhibitor based on a phosphorylation status of SHP2.

Abstract: The present disclosure relates to combinations of inhibitors of SOS1 and inhibitors of RAS useful in the treatment of diseases or disorders.

Abstract: A cloud service receives locations of priority vehicles (PVs) and non-priority vehicles in a metropolitan area. The cloud service accesses a database storing indicia of restricted road portions in the metropolitan area. The cloud service allocates restricted road portions from the database to the NPVs based on the locations of the PVs, the locations of the NPVs, and locations of the restricted road portions. The allocating includes preventing some of the restricted road portions in the database from being available to be allocated to the NPVs based on determining, according to the locations of the PVs and NPVs and according to pre-stored routes of the PVs, that estimated uses of the road portions by the NPVs would conflict with estimated uses of the road portions by the PVs as they travel along the pre-stored routes. Routes generated to include the respectively allocated road portions are provided to the NPVs.

Abstract: A cloud service receives locations of priority vehicles (PVs) and non-priority vehicles in a metropolitan area. The cloud service accesses a database storing indicia of restricted road portions in the metropolitan area. The cloud service allocates restricted road portions from the database to the NPVs based on the locations of the PVs, the locations of the NPVs, and locations of the restricted road portions. The allocating includes preventing some of the restricted road portions in the database from being available to be allocated to the NPVs based on determining, according to the locations of the PVs and NPVs and according to pre-stored routes of the PVs, that estimated uses of the road portions by the NPVs would conflict with estimated uses of the road portions by the PVs as they travel along the pre-stored routes. Routes generated to include the respectively allocated road portions are provided to the NPVs.

Abstract: The present invention is directed to compositions and methods of treating or preventing diseases or disorders with inhibitors of SHP2, alone, and in combination with other therapeutic agents such as RAS pathway inhibitors (e.g., MEK inhibitors); methods of establishing appropriate treatment plans for subjects based upon the expression of one or more biomarker indicative of SHP2 inhibitor sensitivity; and methods of determining sensitivity to a SHP2 inhibitor based on a phosphorylation status of SHP2.

Abstract: The present invention is directed to compositions and methods of treating or preventing diseases or disorders with inhibitors of SHP2, alone, and in combination with other therapeutic agents such as RAS pathway inhibitors (e.g., MEK inhibitors); methods of establishing appropriate treatment plans for subjects based upon the expression of one or more biomarker indicative of SHP2 inhibitor sensitivity; and methods of determining sensitivity to a SHP2 inhibitor based on a phosphorylation status of SHP2.

Abstract: Small molecule inhibitors of XBP1 splicing by IRE1? are provided, as well as methods for their use in treating or preventing cancer (e.g., endocrine resistant breast cancer), diabetes, and obesity.

Abstract: A glutathione-cleavable prodrug is provided herein, as well as methods for its use in treating cancer, including triple negative breast cancer. The prodrug can be cleaved by glutathione under physiological conditions to generate a biologically active agent. The compound described herein is advantageous as the compound is fluorescent and can therefore be monitored within a subject.

Abstract: A glutathione-cleavable prodrug is provided herein, as well as methods for its use in treating cancer, including triple negative breast cancer. The prodrug can be cleaved by glutathione under physiological conditions to generate a biologically active agent. The compound described herein is advantageous as the compound is fluorescent and can therefore be monitored within a subject.

Abstract: Small molecule inhibitors of XBP1 splicing by IRE1? are provided, as well as methods for their use in treating or preventing cancer (e.g., endocrine resistant breast cancer), diabetes, and obesity.

Abstract: The present invention provides avian CSF1 genes encoding proteins which bind avian colony stimulating factor 1 receptor (CSF1R) and which exhibit immunomodulatory properties.

Abstract: The present invention provides avian CSF1 genes encoding proteins which bind avian colony stimulating factor 1 receptor (CSF1R) and which exhibit immunomodulatory properties.

Abstract: Small molecule inhibitors of XBP1 splicing by IRE1 are provided, as well as methods for their use in treating or preventing cancer (e.g., endocrine resistant breast cancer), diabetes, and obesity.

Abstract: Provided are compositions and methods for modulating quorum sensing in microbes. The compounds are AI-2 analogs and as such have structures similar to 4,5-dihydroxy-2,3-pentanedione that can act as agonists/antagonists of quorum sensing. The compounds are useful for modulating quorum sensing in bacteria and can be used in methods for prophylaxis or therapy of bacterial infections and for reduction of biofilms.

Abstract: Provided are compositions and methods for modulating quorum sensing in microbes. The compounds are AI-2 analogs and as such have structures similar to 4,5-dihydroxy-2,3-pentanedione that can act as agonists/antagonists of quorum sensing. The compounds are useful for modulating quorum sensing in bacteria and can be used in methods for prophylaxis or therapy of bacterial infections and for reduction of biofilms.

Abstract: The present invention provides avian CSF1 genes encoding proteins which bind avian colony stimulating factor 1 receptor (CSF1R) and which exhibit immunomodulatory properties.

Abstract: A scoop for the collection of animal refuse comprising a housing having an interior hollow containing an opposing entry and egress opening, the housing having a top wall, opposing side guide walls and a bottom wall arranged adjacent the entry and egress openings, with the bottom wall having an interior scooping surface with an upwardly curved scraping lip with a straight scraping edge for scooping animal waste onto an interior scooping surface of the bottom wall and the egress opening being surrounded by a mounting shoulder extending outwardly from the housing, which is arranged to accept a mounting collar for removably mounting a pliant collection bag to it.

Abstract: In a system that projects application windows onto an information display, one or more users command their respective window applications using laser pointers and/or voice. A registration program assigns a unique identification to each user and associates that user's voice and a particular laser pointer pattern. A sequence of computer decisions checks each laser pointer command so as to correctly associate respective users with their commands and their application windows. Users may speak voice commands. The invention performs speech recognition of the user's voice command. If the command is recognized, the invention performs the speech-recognized command as a window operation.