Abstract: Glass-ceramics exhibiting a Vickers indentation crack initiation threshold of at least 15 kgf are disclosed. These glass-ceramics may be ion exchangeable or ion exchanged. The glass-ceramics include a crystalline and amorphous phases generated by subjecting a thin precursor glass article to ceramming cycle having an average cooling rate in the range from about 10° C./minute to about 25° C./minute. In one or more embodiments, the crystalline phase may comprise at least 20 wt % of the glass-ceramics. The glass-ceramics may include ?-spodumene ss as the predominant crystalline phase and may exhibit an opacity?about 85% over the wavelength range of 400-700 nm for an about 0.8 mm thickness and colors an observer angle of 10° and a CIE illuminant F02 determined with specular reflectance included of a* between ?3 and +3, b* between ?6 and +6, and L* between 88 and 97.

Abstract: A cloud service receives locations of priority vehicles (PVs) and non-priority vehicles in a metropolitan area. The cloud service accesses a database storing indicia of restricted road portions in the metropolitan area. The cloud service allocates restricted road portions from the database to the NPVs based on the locations of the PVs, the locations of the NPVs, and locations of the restricted road portions. The allocating includes preventing some of the restricted road portions in the database from being available to be allocated to the NPVs based on determining, according to the locations of the PVs and NPVs and according to pre-stored routes of the PVs, that estimated uses of the road portions by the NPVs would conflict with estimated uses of the road portions by the PVs as they travel along the pre-stored routes. Routes generated to include the respectively allocated road portions are provided to the NPVs.

Abstract: The present invention is directed to compositions and methods of treating or preventing diseases or disorders with inhibitors of SHP2, alone, and in combination with other therapeutic agents such as RAS pathway inhibitors (e.g., MEK inhibitors); methods of establishing appropriate treatment plans for subjects based upon the expression of one or more biomarker indicative of SHP2 inhibitor sensitivity; and methods of determining sensitivity to a SHP2 inhibitor based on a phosphorylation status of SHP2.

Abstract: A nail manicure method comprising applying a protective coating to portions of the surface of a finger or toe nail or a cuticle adjacent thereto where the application of nail polish is not desired, optionally manipulating the protective coating into a desired shape, and applying nail polish to regions not covered by the protective coating. Once the nail polish has at least partially dried, the protective coating is removed to reveal an underlying area with defined regions of nail polish.

Abstract: The present invention is directed to compositions and methods of treating or preventing diseases or disorders with inhibitors of SHP2, alone, and in combination with other therapeutic agents such as RAS pathway inhibitors (e.g., MEK inhibitors); methods of establishing appropriate treatment plans for subjects based upon the expression of one or more biomarker indicative of SHP2 inhibitor sensitivity; and methods of determining sensitivity to a SHP2 inhibitor based on a phosphorylation status of SHP2.

Abstract: Small molecule inhibitors of XBP1 splicing by IRE1? are provided, as well as methods for their use in treating or preventing cancer (e.g., endocrine resistant breast cancer), diabetes, and obesity.

Abstract: A glutathione-cleavable prodrug is provided herein, as well as methods for its use in treating cancer, including triple negative breast cancer. The prodrug can be cleaved by glutathione under physiological conditions to generate a biologically active agent. The compound described herein is advantageous as the compound is fluorescent and can therefore be monitored within a subject.

Abstract: A glutathione-cleavable prodrug is provided herein, as well as methods for its use in treating cancer, including triple negative breast cancer. The prodrug can be cleaved by glutathione under physiological conditions to generate a biologically active agent. The compound described herein is advantageous as the compound is fluorescent and can therefore be monitored within a subject.

Abstract: Small molecule inhibitors of XBP1 splicing by IRE1? are provided, as well as methods for their use in treating or preventing cancer (e.g., endocrine resistant breast cancer), diabetes, and obesity.

Abstract: The present invention provides avian CSF1 genes encoding proteins which bind avian colony stimulating factor 1 receptor (CSF1R) and which exhibit immunomodulatory properties.

Abstract: The present invention provides avian CSF1 genes encoding proteins which bind avian colony stimulating factor 1 receptor (CSF1R) and which exhibit immunomodulatory properties.

Abstract: Small molecule inhibitors of XBP1 splicing by IRE1 are provided, as well as methods for their use in treating or preventing cancer (e.g., endocrine resistant breast cancer), diabetes, and obesity.

Abstract: A nail manicure method comprising applying a protective coating to portions of the surface of a finger or toe nail or a cuticle adjacent thereto where the application of nail polish is not desired, optionally manipulating the protective coating into a desired shape, and applying nail polish to regions not covered by the protective coating. Once the nail polish has at least partially dried, the protective coating is removed to reveal an underlying area with defined regions of nail polish.

Abstract: A method of creating designs on the surface of a finger nail or toenail is disclosed. A first amount of a flowable protective coating is applied over at least a first portion of a surface of a cuticle adjacent the nail. A first nail polish is applied to the surface of the nail. An additional amount of the flowable protective coating is applied over one or more portions of the surface of the nail coated with the first nail polish. A second nail polish is applied over exposed portions of the nail not covered by the additional amount of the flowable protective coating. The first amount of flowable protective coating and the additional amount of the flowable protective coating are removed by peeling the first amount of flowable protective coating and the additional amount of the flowable protective coating from the cuticle and the nail.

Abstract: Provided are compositions and methods for modulating quorum sensing in microbes. The compounds are AI-2 analogs and as such have structures similar to 4,5-dihydroxy-2,3-pentanedione that can act as agonists/antagonists of quorum sensing. The compounds are useful for modulating quorum sensing in bacteria and can be used in methods for prophylaxis or therapy of bacterial infections and for reduction of biofilms.

Abstract: A nail manicure method comprising applying a protective coating to portions of the surface of a finger or toe nail or a cuticle adjacent thereto where the application of nail polish is not desired, optionally manipulating the protective coating into a desired shape, and applying nail polish to regions not covered by the protective coating. Once the nail polish has at least partially dried, the protective coating is removed to reveal an underlying area with defined regions of nail polish.

Abstract: A nail manicure method and kit, comprising applying a protective coating to portions of the surface of a finger or toe nail where the application of nail polish is not desired, optionally manipulating the protective coating into a desired shape, and applying nail polish to regions not covered by the protective coating. Once the nail polish has at least partially dried, the protective coating is removed to reveal a surface of a nail with well defined regions of nail polish and the region covered by the protective coating. The protective coating is used to generate various customized designs by the user. The protective coating is manipulated by pushing or removing portions of the protective coating using a shaping object. The protective coating is removed by peeling or rubbing. The protective coating comprises rubber and water.

Abstract: Provided are compositions and methods for modulating quorum sensing in microbes. The compounds are AI-2 analogs and as such have structures similar to 4,5-dihydroxy-2,3-pentanedione that can act as agonists/antagonists of quorum sensing. The compounds are useful for modulating quorum sensing in bacteria and can be used in methods for prophylaxis or therapy of bacterial infections and for reduction of biofilms.

Abstract: The present invention provides avian CSF1 genes encoding proteins which bind avian colony stimulating factor 1 receptor (CSF1R) and which exhibit immunomodulatory properties.

Abstract: A fibrous structure product comprising one or more plies of fibrous structure; a basis weight from about 10 lbs/3000 ft2 to about 50 lbs/3000 ft2; from 16% to about 40% of hardwood fibers, in one embodiment eucalyptus fibers, wherein the starting hardwood fibers have a Runkel Ratio of from 4.5 to about 15 and a fiber count of from about 12 fibers/gram to about 35 fibers/gram; and a Residual Water Value from about 0.001 to about 0.18. In one embodiment the product comprises two or more plies of fibrous structure, a basis weight from about 25 lbs/3000 ft2 to about 50 lbs/3000 ft2 and from about 23% to about 40% of hardwood fibers. In another embodiment at least one of the piles of the fibrous structure product further comprises a plurality of embossments thereon comprising an embossment height of from about 600 ?m to about 1,200 ?m.