Patents by Inventor Jacques Acher

Jacques Acher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of providing anxiolytic and antipsychotic treatment
    Patent number: 5141949
    Abstract: Anxiolytic and antipsychotic treatment is provided to patients by administering therapeutically effective amounts of N-[2-(diethylamino)-ethyl]-2-methoxy-4-[(1-H-4,5-dihydro-2-imidazolyl)-ami no]-5-chlorobenzamide, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: October 31, 1991
    Date of Patent: August 25, 1992
    Assignee: Laboratoires Delagrange (Synthelabo)
    Inventors: Jacques Acher, Jean-Claude Monier, Jean-Paul Schmitt, Brenda Costall, Robert Naylor, Renee Gardaix-Luthereau
  • Method of increasing gastrointestinal motility with substituted benzamides
    Patent number: 5116857
    Abstract: The present invention relates to the use of substituted benzamides of formula (1): ##STR1## in which: A is linear or branched C.sub.1 -C.sub.3 alkyl; allyl or diethylaminoethyl;R.sub.1 is hydrogen or methyl, andZ-- is --NH--, --O-- or --S--,and of their pharmacologically acceptable salts for modifying gastric motility.
    Type: Grant
    Filed: December 14, 1989
    Date of Patent: May 26, 1992
    Assignee: Laboratoires Delagrange Div. Societe d'Applications Pharmacodynamiques
    Inventors: Jacques Acher, Jean-Claude Monier, Jean-Paul Schmitt, Brenda Costall, Robert Naylor, Renee Gardaix-Luthereau
  • Method of providing anxiolytic and antipsychotic treatment
    Patent number: 5116859
    Abstract: Anxiolytic and antipsychotic treatment is provided to patients by administering therapeutically effective amounts of N-[2-(diethylamino)-ethyl]-2-methoxy-4-[(1-H-4,5-dihydro-2-immidazolyl)-am ino]-5-chlorobenzamide, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: June 17, 1988
    Date of Patent: May 26, 1992
    Assignee: Laboratoires Delagrange Societe d'Application Pharmacodynamiques
    Inventors: Jacques Acher, Jean-Claude Monier, Jean-Paul Schmitt, Brenda Costall, Robert Naylor, Renee Gardaix-Luthereau
  • Method of treating disorders of cognitive function with substituted benzamides
    Patent number: 5110824
    Abstract: The invention relates to the use of benzamide derivatives of the formula: ##STR1## in which: A is a diethylaminoethyl group or a group of the formula II: ##STR2## where R is a C.sub.1 -C.sub.3 alkyl, allyl, cyclopropylmethyl or cyclohexenylmethyl group,X is a chlorine or bromine atom, andZ is --NH-- or --O-- with the following condition: when Z is --O--, A is a diethylaminoethyl group, and their pharmacologically acceptable salts for the preparation of medicinal products which are useful in the treatment and prevention of disorders of the cognitive function.
    Type: Grant
    Filed: April 12, 1990
    Date of Patent: May 5, 1992
    Assignee: Societe d'Etudes Scientifiques et Industrielles de L'Ile-de-France
    Inventors: Jacques Acher, Jean-Claude Monier, Jean-Paul Schmitt, Renee Gardaix-Luthereau, Brenda Costall, Robert Naylor
  • Method of providing anxiolytic and antipsychotic treatment with substituted benzamides
    Patent number: 5086066
    Abstract: The present invention relates to the application of substituted benzamides of formula (I): ##STR1## in which: A is diethylaminoethyl, 1-ethyl-2-pyrrolidinylmethyl or 1-allyl-2-pyrrolidinylmethyl;R.sub.1 is hydrogen or methyl;X is chlorine or bromine;Z is --NH-- or --O-- except when Z is --NH--,R.sub.1 is hydrogen and X is chlorine, and of their pharmacologically acceptable addition salts, as anxiolytics and antipsychotics.
    Type: Grant
    Filed: December 20, 1989
    Date of Patent: February 4, 1992
    Assignee: Laboratoires Delagrange Societe d'Applications Pharmacodnymiques
    Inventors: Jacques Acher, Jean-Claude Monier, Jean-Paul Schmitt, Renee Gardaix-Luthereau, Robert Naylor, Brenda Costall
  • Novel benzamides, intermediates and process for the preparation and therapeutic use thereof
    Patent number: 4914117
    Abstract: New substituted benzamides have the general formula: ##STR1## their optical isomers and their physiologically acceptable salts. The compounds are used as activators of the central nervous system.
    Type: Grant
    Filed: March 13, 1989
    Date of Patent: April 3, 1990
    Assignee: Societe d'Etudes Scientifiques et Industrielle de l'Ile-d-France
    Inventors: Jacques Acher, Jean-Claude Monier, Jean-Paul Schmitt, Gardaix-Luthereau Renee, Brenda Costall, Robert Naylor
  • Novel benzamides, intermediates and process for the preparation and therapeutic use thereof
    Patent number: 4835172
    Abstract: New substituted benzamides have the general formula: ##STR1## A=alkyl, alkenyl, diethylaminoethyl or ##STR2## R.sub.1, R.sub.2 =H, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl; R.sub.3, R.sub.4, R.sub.5, R.sub.6 =hydrogen or C.sub.1 -C.sub.6 alkyl;X=halogen;Y=H, halogen;Z=NH, oxygen or sulfur;their optical isomers and their physiologically acceptable salts. The compounds are used as activators of the central nervous system.
    Type: Grant
    Filed: December 19, 1986
    Date of Patent: May 30, 1989
    Assignee: Societe D'Etudes Scientifiques et Industrielles de L'Ile-de-France
    Inventors: Jacques Acher, Jean-Claude Monier, Jean-Paul Schmitt, Renee Gardaix-Luthereau, Brenda Costall, Robert Naylor
  • Substituted heterocyclic benzamides, methods of preparing them and their application as anti-emetics
    Patent number: 4816471
    Abstract: There are provided substituted heterocyclic benzamides and derivatives thof which exhibit strong anti-emetic properties.
    Type: Grant
    Filed: April 30, 1986
    Date of Patent: March 28, 1989
    Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ille-de France
    Inventors: Michel Thominet, Jacques Acher, Jean-Claude Monier
  • Process for synthesizing N-[(1'-allyl-2'pyrrolidinyl) methyl]2-methoxy-4,5-azimidobenzamide
    Patent number: 4804765
    Abstract: The invention concerns a novel process for the synthesis of N-[(1'-allyl-2'-pyrrolidinyl) methyl]-2-methoxy-4,5-azimidobenzamide, which successively comprises the preparation of 2-methoxy-4,5-diaminobenzoic acid, 2-methoxy-4,5-diacetylaminobenzoic acid, N-(2',5'-dihalopentyl)-2-methoxy-4,5-diacetylaminobenzamide, N-[(1'-allyl-2'-pyrrolidinyl) methyl]-2-methoxy-4,5-diacetylaminobenzamide and then N-[(1'-allyl-2'-pyrrolidinyl) methyl]-2-methoxy-4,5-azimido benzamide.
    Type: Grant
    Filed: December 18, 1985
    Date of Patent: February 14, 1989
    Assignee: Societe D'Etudes Scientifiques et Industrielles de L'Ile-d-France
    Inventors: Jacques Acher, Jean-Claude Monier
  • New substituted heterocyclic benzamides, methods of preparing them and their application as behavior modifiers
    Patent number: 4673686
    Abstract: There are provided new substituted heterocyclic benzamides and derivatives hereof which provide modifications on the central nervous system.
    Type: Grant
    Filed: August 26, 1985
    Date of Patent: June 16, 1987
    Assignee: Societe d'Etudes Scientifiques et Industrielle de l'Ile de France
    Inventors: Michel Thominet, Jacques Acher, Jean-Claude Monier
  • Derivatives of 4-amino-5-alkyl sulphonyl orthoanisamides
    Patent number: 4401822
    Abstract: N-(1-lower alkyl or alkenyl-2-pyrrolidinylmethyl)-2-lower alkoxy-4-amino-ower alkylsulphonylbenzamides and derivatives thereof which have antiapomorphine and antiserotonin activity.
    Type: Grant
    Filed: October 9, 1981
    Date of Patent: August 30, 1983
    Assignee: Societe de'Etudes Scientifiques et Industrielles de l'Ile-de France
    Inventors: Michel Thominet, Jacques Acher, Jean-Claude Monier
  • Substituted 2,3-alkylene di (oxy) benzamides and derivatives
    Patent number: 4323503
    Abstract: Novel substituted 2,3-alkylene bis (oxy) benzamides and derivatives thereof are disclosed. Also disclosed is a method for producing said compounds. The compounds have anxiolytic, psychostimulant, disinhibiting and thymoanaleptic properties useful therapeutically in the psychofunctional field, particularly in gastro-enterology, cardiology, urology, rheumatology and gynaecology.
    Type: Grant
    Filed: June 12, 1979
    Date of Patent: April 6, 1982
    Assignee: Societe d'Etudes Scientifiques et Industrielles de L'ile-de-France
    Inventors: Michel Thominet, Gerard Bulteau, Jacques Acher, Claude Collignon
  • Substituted 2,3-alkylene bis (oxy)-4,5 (or 5,6) azimido benzamides and derivatives thereof
    Patent number: 4306072
    Abstract: Novel substituted 2,3-alkylene bis (oxy) benzamide azimido compounds and derivatives thereof are disclosed as for example N-(1-allyl-2-pyrrolidylmethyl)-7,8-azimido-1,4-benzodioxane-5-carboxamide and N-(1-allyl-2-pyrrolidylmethyl)-6,7-azimido-1,4-benzodioxane-5-carboxamide. The compounds have anxiolytic, psychostimulant, disinhibiting and thymoanaleptic properties useful therapeutically in the psychofunctional field, particularly in gastro-enterology, cardiology, urology, rheumatology and gynaecology.
    Type: Grant
    Filed: July 26, 1979
    Date of Patent: December 15, 1981
    Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ile
    Inventors: Michel Thominet, Gerard Bulteau, Jacques Acher, Claude Collignon
  • New derivatives of 4-amino-5-alkyl sulphonyl orthoanisamides, methods of preparing them and their application as psychotropic agents
    Patent number: 4294828
    Abstract: There are provided certain N-(1-lower alkyl-2-pyrrolidylmethyl)2-lower aly-4-amino-5-lower alkyl sulphonyl benzamides and derivatives thereof which provide surprising antiapomorphine and antiserotonin activity.
    Type: Grant
    Filed: January 18, 1979
    Date of Patent: October 13, 1981
    Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ile de-France
    Inventors: Michel Thominet, Jacques Acher, Jean-Claude Monier
  • Substituted 2,3-alkylene bis (oxy) benzamides and derivatives and method of preparation
    Patent number: 4268512
    Abstract: Novel substituted 2,3-alkylene bis (oxy) benzamides and derivatives thereof are disclosed. Also disclosed is a method for producing said compounds. The compounds have anxiolytic, psychostimulant, disinhibiting and thymoanaleptic properties useful therapeutically in the psychofunctional field, particularly in gastro-enterology, cardiology, urology, rheumatology and gynaecology.
    Type: Grant
    Filed: February 23, 1979
    Date of Patent: May 19, 1981
    Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ile-de-France
    Inventors: Michel Thominet, Gerard Bulteau, Jacques Acher, Claude Collignon
  • Substituted 2,3-alkylene bis(oxy) benzamides and derivatives to treat psychofunctional disorders
    Patent number: 4248885
    Abstract: Novel substituted 2,3-alkylene bis (oxy) benzamides and derivatives thereof are disclosed. Also disclosed is a method for producing said compounds. The compounds have anxiolytic, psychostimulant, disinhibiting and thymoanaleptic properties useful therapeutically in the psychofunctional field, particularly in gastro-enterology, cardiology, urology, rheumatology and gynaecology.
    Type: Grant
    Filed: February 23, 1979
    Date of Patent: February 3, 1981
    Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ile-de-France
    Inventors: Michel Thominet, Gerard Bulteau, Jacques Acher, Claude Collignon
  • Substituted 2,3-alkylene bis (oxy) benzamides and derivatives and method of preparation
    Patent number: 4186135
    Abstract: Novel substituted 2,3-alkylene bis (oxy) benzamides and derivatives thereof are disclosed. Also disclosed is a method for producing said compounds. The compounds have anxiolytic, psychostimulant, disinhibiting and thymoanaleptic properties useful therapeutically in the psychofunctional field, particularly in gastro-enterology, cardiology, urology, rheumatology and gynaecology.
    Type: Grant
    Filed: August 2, 1977
    Date of Patent: January 29, 1980
    Assignee: Societe D'Etudes Scientifiques et Industrielles de L'ile-de-France
    Inventors: Michel Thominet, Gerard Bulteau, Jacques Acher, Claude Collignon
  • Process for producing enamines
    Patent number: 4166060
    Abstract: Enamines which are employed to obtain benzamides effective in the treatment of emesis are produced by efficient processes.
    Type: Grant
    Filed: December 21, 1977
    Date of Patent: August 28, 1979
    Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ile-de-France
    Inventors: Gerard Bulteau, Jacques Acher, Jean-Claude Monier
  • N-(1'-ethyl-2'-oxo-5'-pyrrolidinylmethyl) benzamide compounds and derivatives, method of preparation and pharmaceutical preparations
    Patent number: 4161532
    Abstract: Novel substituted N-(1'-ethyl-2'-oxo-5'-pyrrolidinylmethyl) benzamide comnds and derivatives thereof are disclosed. The compounds have psychotropic properties and may be used in pharmaceutical compositions as behavior modifiers.
    Type: Grant
    Filed: April 14, 1978
    Date of Patent: July 17, 1979
    Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ile de France
    Inventors: Gerard Bulteau, Jacques Acher, Jean C. Monier
  • Enamines, their derivatives and processes of production
    Patent number: 4077976
    Abstract: The enamines of this invention are useful in the preparation of certain benzamides employed in the treatment of emesis in mammals.
    Type: Grant
    Filed: June 11, 1976
    Date of Patent: March 7, 1978
    Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ile-de-France
    Inventors: Gerard Bulteau, Jacques Acher, Jean-Claude Monier