Patents by Inventor Jacques Bailly

Jacques Bailly has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for differentiation of pluripotent stem cells into multi-competent renal precursors
    Patent number: 10138468
    Abstract: This application relates to a method for differentiating pluripotent stem cells (PSCs) into multi-competent renal precursor cells expressing Six2. These renal precursor cells are able to differentiate into fully functional and fully differentiated podocytes. Moreover this application relates to a method for differentiating human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) into defined renal precursor cells expressing Six2 and podocytes based on linked steps of chemically defined medium inductions.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: November 27, 2018
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jacques Bailly, Osele Ciampi, Martin Graf, Roberto Iacone, Christoph Patsch
  • METHOD FOR DIFFERENTIATION OF PLURIPOTENT STEM CELLS INTO MULTI-COMPETENT RENAL PRECURSORS
    Publication number: 20160145578
    Abstract: This application relates to a method for differentiating pluripotent stem cells (PSCs) into multi-competent renal precursor cells expressing Six2. These renal precursor cells are able to differentiate into fully functional and fully differentiated podocytes. Moreover this application relates to a method for differentiating human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) into defined renal precursor cells expressing Six2 and podocytes based on linked steps of chemically defined medium inductions.
    Type: Application
    Filed: January 29, 2016
    Publication date: May 26, 2016
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Jacques Bailly, Osele Ciampi, Martin Graf, Roberto Iacone, Christoph Patsch
  • Glucocorticoid receptor antagonists
    Patent number: 8883786
    Abstract: The present invention relates to compounds of formula I wherein A, n, R1a to R1e and R2 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.
    Type: Grant
    Filed: February 13, 2012
    Date of Patent: November 11, 2014
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jacques Bailly, Cornelia Hertel, Daniel Hunziker, Christian Lerner, Ulrike Obst Sander, Jens-Uwe Peters, Philippe Pflieger, Tanja Schulz-Gasch
  • GLUCOCORTICOID RECEPTOR ANTAGONISTS
    Publication number: 20130045972
    Abstract: The present invention relates to compounds of formula I wherein A, n, R1a to R1e and R2 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.
    Type: Application
    Filed: February 13, 2012
    Publication date: February 21, 2013
    Inventors: Jacques Bailly, Cornelia Hertel, Daniel Hunziker, Christian Lerner, Ulrike Obst Sander, Jens-Uwe Peters, Philippe Pflieger, Tanja Schulz-Gasch
  • Glucocorticoid receptor antagonists
    Patent number: 8143280
    Abstract: The present invention relates to compounds of formula I wherein A, n, R1a to R1e and R2 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.
    Type: Grant
    Filed: September 15, 2008
    Date of Patent: March 27, 2012
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jacques Bailly, Cornelia Hertel, Daniel Hunziker, Christian Lerner, Ulrike Obst Sander, Jens-Uwe Peters, Philippe Pflieger, Tanja Schulz-Gasch
  • COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF GLUCOCORTICOID RECEPTOR (GCR) GENES
    Publication number: 20110020300
    Abstract: This invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a GCR gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a GCR gene using said pharmaceutical composition; and methods for inhibiting the expression of GCR in a cell.
    Type: Application
    Filed: May 14, 2010
    Publication date: January 27, 2011
    Applicant: GENENTECH, INC.
    Inventors: JACQUES BAILLY, AGNÈS BÉNARDEAU, BIRGIT BRAMLAGE, RAINER CONSTIEN, ANDREA FORST, MARKUS HOSSBACH, BRIGITTE SCHOTT
  • Anti-obesity compositions
    Patent number: 7816342
    Abstract: The present invention relates to compositions and methods for treating obesity. More particularly, the invention relates to a composition comprising a lipase inhibitor such as orlistat, and glucomannan such as konjac as well as methods for utilizing such compositions and kits for carrying out this method.
    Type: Grant
    Filed: February 7, 2006
    Date of Patent: October 19, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jacques Bailly, Rainer Eugen Martin, Susanne Raab
  • GLUCOCORTICOID RECEPTOR ANTAGONISTS
    Publication number: 20090088425
    Abstract: The present invention relates to compounds of formula I wherein A, n, R1a to R1e and R2 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.
    Type: Application
    Filed: September 15, 2008
    Publication date: April 2, 2009
    Inventors: Jacques Bailly, Cornelia Hertel, Daniel Hunziker, Christian Lerner, Ulrike Obst Sander, Jens-Uwe Peters, Philippe Pflieger, Tanja Schulz-Gasch
  • Anti-obesity compositions
    Publication number: 20060135471
    Abstract: The present invention relates to compositions and methods for treating obesity. More particularly, the invention relates to a composition comprising a lipase inhibitor such as orlistat, and glucomannan such as konjac as well as methods for utilizing such compositions and kits for carrying out this method.
    Type: Application
    Filed: February 7, 2006
    Publication date: June 22, 2006
    Inventors: Jacques Bailly, Rainer Martin, Susanne Raab
  • Anti-obesity compositions
    Publication number: 20040033983
    Abstract: The present invention relates to compositions and methods for treating obesity. More particularly, the invention relates to a composition comprising a lipase inhibitor such as orlistat, and glucomannan such as konjac as well as methods for utilizing such compositions and kits for carrying out this method.
    Type: Application
    Filed: April 23, 2003
    Publication date: February 19, 2004
    Inventors: Jacques Bailly, Rainer Eugen Martin, Susanne Raab
  • Pharmaceutical composition containing chitosan
    Patent number: 6030953
    Abstract: The present invention provides orally administrable pharmaceutical compositions containing an inhibitor of gastrointestinal lipase, and at least one compound selected from the group consisting of chitosan, its derivatives and salts thereof. Methods are provided for preventing and treating anal leakage of oil in a patient to whom a composition containing an inhibitor of gastrointestinal lipase is orally administered.
    Type: Grant
    Filed: August 10, 1999
    Date of Patent: February 29, 2000
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jacques Bailly, Andre Fleury, Paul Hadvary, Hans Lengsfeld, Hans Steffen
  • Method of diagnosing epidermis differentiation disorders in a patient using a stratum corneum-specific antibody
    Patent number: 5541073
    Abstract: The subject invention relates to a method of diagnosing epidermis differentiation disorders in a patient by obtaining an epidermis sample from the patient, adding to the sample, antibodies that specifically bind to an antigen of the stratum corneum, the said antigen being specifically recognized by BC 21 monoclonal antibody and detecting the presence or absence of the antibodies that are specifically bound to the epidermis sample.
    Type: Grant
    Filed: April 22, 1994
    Date of Patent: July 30, 1996
    Assignee: Centre International De Recherches Dermatologiques Galderma (Cird Galderma)
    Inventors: Serge Michel, Jacques Bailly, Gaelle Saintigny, Uwe Reichert
  • Hybridoma producing a monoclonal antibody specific for an antigen of the stratum corneum of human epidermis
    Patent number: 5312751
    Abstract: The subject invention relates to monoclonal antibodies which react with antigenic determinants which are present of the stratus corneum of human epidermis. Furthermore, the invention also relates to methods of using such monoclonal antibodies in immunoassays. One monoclonal antibody of the present invention which is particularly useful is BC 21.
    Type: Grant
    Filed: February 7, 1991
    Date of Patent: May 17, 1994
    Assignee: Centre International de Recherches Dermatologiques Galderma (Cird Galderma)
    Inventors: Serge Michel, Jacques Bailly, Gaelle Saintigny, Uwe Reichert