Patents by Inventor Jacques Bertrand Brocard

Jacques Bertrand Brocard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified nuclear glucocorticoid receptor, fusion protein, and DNA fragments coding for said receptor and said fusion protein
    Patent number: 6699686
    Abstract: A DNA fragment coding for a modified nuclear glucocorticoid receptor, particularly one mutated in the region coding for the ligand binding domain, so that receptor activity is more strongly inducible by a synthetic glucocorticoid ligand than by a natural glucocorticoid ligand, is disclosed. A recombination system inducible in mammals by means of a fusion protein produced between a recombinase and the binding domain of the ligand derived from the modified glucocorticoid receptor of which the activity is more strongly inducible by synthetic glucocorticoids than by natural glucocorticoids, is also disclosed.
    Type: Grant
    Filed: August 20, 1998
    Date of Patent: March 2, 2004
    Assignee: Association pour le Development de la Recherche en Genetique Moleculaire (ADEREGEM)
    Inventors: Jacques Bertrand Brocard, Pierre Henri Chambon, Hinrich Gronemeyer, Daniel Metzger, Jean-Claude Nicolas, Sylvie Roux