Patents by Inventor Jacques Defaye

Jacques Defaye has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8440814
    Abstract: The invention relates to a compound corresponding to general formula (I) wherein n is a whole number from 1-6, m is a whole number equal to 5, 6 or 7, R1 is an OH group, all R1 s are identical, Z is an NHX group, X is a hydrogen atom, and R is a hydrogen atom or a bioidentification element, with the proviso that the compound wherein n=1, m=6, Z=NH2 and R1=OH is excluded.
    Type: Grant
    Filed: May 19, 2009
    Date of Patent: May 14, 2013
    Assignees: Centre National de la Recherche Scientifique, Universite Joseph Fourier, Consejo Superior de Investigaciones Cientificas (CSIC), Universidad de Sevilla
    Inventors: Jacques Defaye, Carmen Ortiz-Mellet, Jose Manuel Garcia-Fernandez, Maria Gomez-Garcia, Kazimierz Chmurski, Jian-Xin Yu
  • Patent number: 7781417
    Abstract: The invention relates to a compound according to the following general formula (I), in which: m represents an integer equal to 5, 6 or 7; n and n1 represent an integer from 1 to 5; the A groups represent, in particular, a hydrogenated atom; X represents O or S; Y represents, in particular, a group NR1, R1, representing, in particular, a hydrogenated atom; W represents CH or N; and Z represents, in particular, a hydrogenated atom.
    Type: Grant
    Filed: November 24, 2004
    Date of Patent: August 24, 2010
    Assignees: Centre National de la Recherche Scientifique, Universite Joseph Fourier, Consejo Superior de Investigaciones Cientificas (CSIC), Universidad de Sevilla
    Inventors: Jacques Defaye, Carmen Ortiz-Mellet, José Manuel Garcia-Fernandez, Juan M. Benito, Marta Gomez-Garcia, Jian-Xin Yu
  • Publication number: 20100093662
    Abstract: The present invention relates to cyclodextrins having the following formula (I): to nanostructures comprising them, to processes for preparing them, to the use thereof, and also to compositions comprising them.
    Type: Application
    Filed: July 20, 2007
    Publication date: April 15, 2010
    Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS-
    Inventors: Jacques Defaye, Alejandro Diaz Moscoso, Annabelle Geze, Pierre Vierling, Patricia Balbuena, Juan M. Benito, Christophe Di Giorgio, Jose Garcia Fernandez, Marta Gomez Garcia, Carmen Ortiz Mellet, Denis Wouessidjewe
  • Patent number: 7632941
    Abstract: The invention relates to a cyclodextrin derivative corresponding to general formula (I) wherein n is a whole number from 1-6, m is a whole number equal to 5, 6 or 7, R1 is an OH group, all R1s are identical, Z is a thiourea group, X is a hydrogen atom, and R is a hydrogen atom or a bioidentification element.
    Type: Grant
    Filed: March 22, 2004
    Date of Patent: December 15, 2009
    Assignees: Centre National de la Recherche Scientifique, Universite Joseph Fourier, Consejo Superior de Investigaciones Cientificas (CSIC), Universidad de Sevilla
    Inventors: Jacques Defaye, Carmen Ortiz-Mellet, José Manuel Garcia-Fernandez, Maria Gomez-Garcia, Kazimierz Chmurski, Jian-Xin Yu
  • Publication number: 20090264540
    Abstract: The invention relates to a compound corresponding to general formula (I) wherein n is a whole number from 1-6, m is a whole number equal to 5, 6 or 7, R1 is an OH group, all R1 s are identical, Z is an NHX group, X is a hydrogen atom, and R is a hydrogen atom or a bioidentification element, with the proviso that the compound wherein n=1, m=6, Z=NH2 and R1=OH is excluded.
    Type: Application
    Filed: May 19, 2009
    Publication date: October 22, 2009
    Inventors: Jacques DEFAYE, Carmen Ortiz-Mellet, Jose Manuel Garcia-Fernandez, Maria Gomez-Garcia, Kazimierz Chmurski, Jian-Xin Yu
  • Publication number: 20070167401
    Abstract: The invention relates to a compound corresponding to general formula (I) wherein n is a whole number from 1-6, m is a whole number equal to 5, 6 or 7, R1 is an OH group, all R1s are identical, Z is an NHX group, X is a hydrogen atom, and R is a hydrogen atom or a bioidentification element, with the proviso that the compound wherein n=1, m=6, Z=NH2 and R1=OH is excluded.
    Type: Application
    Filed: March 22, 2004
    Publication date: July 19, 2007
    Inventors: Jacques Defaye, Carmen Ortiz-Mellet, Jose Garcia-Fernandez, Maria Gomez-Garcia, Kazimierz Chmurski, Jian-Xin Yu
  • Publication number: 20070082867
    Abstract: The invention relates to a compound according to the following general formula (I), in which: m represents an integer equal to 5, 6 or 7; n and n1 represent an integer from 1 to 5; the A groups represent, in particular, a hydrogenated atom; X represents O or S; Y represents, in particular, a group NR1, R1, representing, in particular, a hydrogenated atom; W represents CH or N; and Z represents, in particular, a hydrogenated atom.
    Type: Application
    Filed: November 24, 2004
    Publication date: April 12, 2007
    Inventors: Jacques Defaye, Carmen Ortiz-Mellet, Jose Manuel Garcia-Fernandez, Juan Benito, Marta Gomez-Garcia, Jian-Xin Yu
  • Patent number: 6570009
    Abstract: The invention relates to a highly regioselective method for preparing a derivative of cyclodextrin, &bgr;-cyclodextrin in particular, monosulfonylated at C-6, in which said cyclodextrin is caused to react with a sulfonylation agent, in an alkaline aqueous solution, in the presence of a metal salt able to form a co-ordination complex with the secondary hydroxyl groups of the cyclodextrin, and after the reaction said cyclodextrin derivative monosulfonylated at C-6 is recovered from the reaction mixture. The monosulfonylated derivatives of cyclodextrins find particular application as starting material for access to monofunctionalized derivatives of cyclodextrins.
    Type: Grant
    Filed: December 20, 2000
    Date of Patent: May 27, 2003
    Assignee: Centre National de la Recherche Scientifique
    Inventors: Jacques Defaye, Serge Crouzy, Nicolas Evrard, Ho Law
  • Patent number: 6080733
    Abstract: The invention relates to thioureido-cyclodextrins, usable in particular to solubilize anti-tumor and antiparasitic agents and their preparation processes.These thioureido-cyclodextrins correspond to the formula: ##STR1## with m=6, 7 or 8, R.sup.1 represents OH or NH--CS--NHR.sup.2, at least one of the R.sup.1 being NH--CS--NHR.sup.2,R.sup.2 represents an alkyl, monosaccharide, oligosaccharide glycosyl-amino acid or glycopeptide group.These cyclodextrins are usable for solubilizing anti-tumor or antiparasitic agents of the Taxol family.
    Type: Grant
    Filed: October 20, 1998
    Date of Patent: June 27, 2000
    Assignee: Centre National de la Recherche Scientifique
    Inventors: Jacques Defaye, Carmen Ortiz-Mellet, Jose-Manuel Garcia-Fernandez
  • Patent number: 5798342
    Abstract: The invention relates to the use of natural cyclodextrins and their derivatives for the solubilization of platelet anti-aggregating agents from the family of Ginkgolides.The cyclodextrins used comply with the formula: ##STR1## in which n is equal to 6, 7 or 8 and the R.sup.1, which can be the same or different, represent OH or SR.sup.2 with R.sup.2 representing a group derived from a monosaccharide or an oligosaccharide.The Ginkgolide is preferably Ginkgolide B.
    Type: Grant
    Filed: September 9, 1996
    Date of Patent: August 25, 1998
    Assignee: Commissariat a l'Energie Atomique
    Inventors: Jacques Defaye, Valerie Laine, Florence Djedaini-Pilard, Bruno Perly
  • Patent number: 5417755
    Abstract: An amphoteric starch containing carboxyl and cationic groups characterized in that its carboxyl groups originate from the selective oxidation of the hemiacetal groups of the cationic starch and possibly of the hemiacetal groups of its products of acid hydrolysis. The process for producing the amphoteric starch consists in reacting a cationic starch in aqueous solution with hydrogen peroxide and hydrobromic acid or bromine, so as to oxidize selectively the hemiacetal groups of the cationic starch and, where appropriate, the hemiacetal groups of its products of acid hydrolysis, to give carboxyl groups.
    Type: Grant
    Filed: June 21, 1994
    Date of Patent: May 23, 1995
    Assignee: Elf Atochem, S.A.
    Inventors: Sophie Suc, Jacques Defaye, Andree Gadelle, Jacques Kervennal
  • Patent number: 5383964
    Abstract: This process consists in reacting a cationic starch in aqueous solution with hydrogen peroxide and hydrobromic acid or bromine, so as to oxidize selectively the hemiacetal groups of the cationic starch and, where appropriate, the hemiacetal groups of its products of acid hydrolysis, to give carboxyl groups. The amphoteric starch containing carboxyl and cationic groups, thus obtained, is characterized in that its carboxyl groups originate from the selective oxidation of the hemiacetal groups of the cationic starch and possibly of the hemiacetal groups of its products of acid hydrolysis.
    Type: Grant
    Filed: March 22, 1993
    Date of Patent: January 24, 1995
    Assignee: Elf Atochem S.A.
    Inventors: Sophie Suc, Jacques Defaye, Andree Gadelle, Jacques Kervennal
  • Patent number: 5118804
    Abstract: A process for preparing alkykl-1-thio-.alpha.,.beta.-glycosides and alkyl glycosides is described. The glycosides are prepared from a saccharide selected from monosaccharides and reducible di- and oligo-saccharides. The saccharide is reacted with either a thiol to produce an alkyl-1-thio-.alpha.,.beta.-glycoside or an alcohol to produce an alkyl glycoside in the presence of the solvent and reagent poly-(hydrogen fluoride)-pyridinium. Novel alkyl-1-thio-.alpha.,.beta.-glycosides prepared by the process of the invention are characterized in that they are in the form of a mixture of .alpha. and .beta. anomers. The alkyl-1-thio-.alpha.,.beta.-glycosides having a long alkyl chain are useful as nonionic detergents, in particular in the extraction of membrane proteins.
    Type: Grant
    Filed: July 31, 1990
    Date of Patent: June 2, 1992
    Assignee: Beghin-Say, SA
    Inventors: Jacques Defaye, Andree Gadelle, Christian Pedersen
  • Patent number: 4861871
    Abstract: The invention concerns a process for dehydrating glucides and applicable to those glucides of which the molecule includes at least one ketose type group, being characterized in that the glucide is made to react without addition of water with a hydrogen halide, whereupon the hydrogen halide is eliminated by evaporation in order to collect the formed disaccharide anhydride.The invention also relates to novel products characterized by essentially consisting of saccharide anhydrides of which the molecule includes two saccharide cycles linked to each other by two acetal bonds included in a dioxane cycle. As a rule at least one of the saccharide cycles is that of fructose (and may be substituted), and this cycle is linked by a spirane bond to the dioxane cycle.Product application as food additives.
    Type: Grant
    Filed: April 11, 1988
    Date of Patent: August 29, 1989
    Assignee: Beghin-Say S.A.
    Inventors: Jacques Defaye, Andree Gadelle, Christian Pedersen
  • Patent number: 4739043
    Abstract: The process comprises the action of a saturated aliphatic or cycloaliphatic alcohol or an aliphatic or cycloaliphatic alcohol comprising a double ethylenic bound not situated in alpha of the hydroxyl group with an aldose, aldoside or polyaldoside in the solvent and reactant formed by the hydrogen fluoride. Application to the synthesis of surfactants or as additives for rigidifying polyurethane foams.
    Type: Grant
    Filed: April 18, 1986
    Date of Patent: April 19, 1988
    Assignee: Beghin-Say, S.A.
    Inventors: Jacques Defaye, Emile Wong, Christian Pedersen, Jean Chedin, Alain Bouchu
  • Patent number: 4737584
    Abstract: The invention concerns a process for dehydrating glucides and applicable to those glucides of which the molecule includes at least one ketose type group, being characterized in that the glucide is made to react without addition of water with a hydrogen halide, whereupon the hydrogen halide is eliminated by evaporation in order to collect the formed disaccharide anhydride.The invention also relates to novel products characterized by essentially consisting of saccharide anhydrides of which the molecule includes two saccharide cycles linked to each other by two acetal bonds included in a dioxane cycle. As a rule at least one of the saccharide cycles is that of fructose (and may be substituted), and this cycle is linked by a spirane bond to the dioxane cycle.Product application as food additives.
    Type: Grant
    Filed: April 5, 1985
    Date of Patent: April 12, 1988
    Assignee: Beghin-Say S.A.
    Inventors: Jacques Defaye, Andree Gadelle, Christian Pedersen