Abstract: Compounds, compositions and their use in the treatment of a proliferative disease or condition such as a said proliferative disease or disorder is associated with a RAF gene mutation and/or a RAS gene mutation.

Abstract: A direct drive valve includes a rotary motor transmitting a linear movement to a hydraulic valve through an arm linked to the engine and acting on a clevis integral with the valve. A spring acting on one end of the valve provides clearance adjustment of the connection between the engine and the valve and enables the return of the latter into a predetermined safety position in the event of breakdown of the system. The valve is for use in motor vehicle applications.

Abstract: An arrangement for damping movement of a mass with respect to a support to which the mass is connected by a suspension device. The suspension device is provided with one or more springs and a hydraulic damping system through which a hydraulic fluid flows. One or more devices are present for wire-drawing this fluid through a respective aperture. Each wire-drawing device is arranged to continuously vary the damping characteristics by controlling the extent of opening of the aperture(s) and thus regulate the flow of the fluid through the hydraulic damping system.

Abstract: Mechanically controlled power transmission device comprising a rotary engine driving, through a lever and a clevis, a hydraulic slide valve which consists, in a known manner, of a rod sliding in a hole and includes blocks capable of selectively establishing communication between firstly a user device and secondly a high pressure source or an outlet. Two springs act on the slide valve in opposite directions, return the latter, in the event of a breakdown, into a neutral position which is preferably a position in which no communication is established. The device of the invention is for use in the motor car industry.

Abstract: The invention concerns a crankcase or cylinder block for an internal combustion engine of any type, for example, of the V or in-line cylinder type. The upper half of the crankcase comprises internal conduits which connect the upper part of the crankcase with the lower compartments separating the crankshaft bearings, these conduits making possible the exhaust of crankcase gases and the recycling of the engine oil and opening into a chamber of a flat shape, with said chamber and said internal conduits forming an integral as-cast system. The invention applies in particular to the automotive industry.

Abstract: A retainer for the parts of the interior assembly of sliding automotive universal joints, for example, of the tripod type constituted, of a splined hub with trunnions which support rollers with interposed bearing means, such as needle bearings. The retainer (1) is a flat slitted ring (2) made of a slightly elastically deformable material and has regularly spaced open seats (L) for receiving rollers (12), and holder (6,7) to retain the rollers (12) and needle bearings (13) in position on the trunnions (11) of the interior assembly of the universal joint.

Abstract: A universal coupling comprising an outer element integral with a first shaft having a spherical cavity inside which are formed grooves, an inner element integral with a second shaft and having an external surface in which grooves are also formed whose bottom has a section through a plane passing through the axis of the inner element formed by an arc of a curve, rolling means being disposed between the pairs of grooves, these rolling means being held in the windows of a cage. The inner element has on its outer surface a cylindrical surface portion situated substantially in the median region in the axial direction and extending at least substantially as far as the plane orthogonal to the axis containing the points of the bottoms the furthest from the axis, this portion being extended on each side by spherical surface portions intended to mate with the inner surface of the cage.