Patents by Inventor Jacques Duhault

Jacques Duhault has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6596749
    Abstract: Method of treating with compounds of formula (I): wherein: n is 0 or 1, W represents —CO— or S(O)q and q is 0, 1 or 2, G represents a G1, G2, G3 or G4 group as defined in the description, Z represents alkyl, aryl, heteroaryl, arylalkyl, arylalkenyl, arylalkynyl, heteroarylakenyl, heteroarylalkynyl or heteroarylalkyl each optionally substituted, A represents a grouping selected from —A2—, —A1—A2—, —A2—A1—, and —A1—A2—A1— wherein A1 is alkylene and A2 represents phenylene, cycloalkylene, naphthylene or heteroarylene each optionally substituted, R represents hydrogen, alkyl, aryl, heteroaryl, arylalkyl arylalkenyl, arylalkynyl, heteroarylakenyl, heteroarylalkynyl or heteroarylalkyl each optionally substituted, R1 represents alkyl, aryl, heteroaryl, arylalkyl arylalkenyl, arylalkynyl, heteroarylakenyl, heteroarylalkynyl or heteroarylalkyl each optionally substituted, and medicinal products containing the
    Type: Grant
    Filed: March 5, 2001
    Date of Patent: July 22, 2003
    Assignee: Les Laboratoires Servier
    Inventors: Jean-Luc Fauchere, Jean-Claude Ortuno, Jacques Duhault, Jean Albert Boutin, Nigel Levens
  • Publication number: 20010018522
    Abstract: Compound of formula (I): 1
    Type: Application
    Filed: March 5, 2001
    Publication date: August 30, 2001
    Inventors: Jean-Luc Fauchere, Jean-Claude Ortuno, Jacques Duhault, Jean Albert Boutin, Nigel Levens
  • Patent number: 6271247
    Abstract: Compounds of formula (I): R—NH—A—CO—NH—NH—(W)n—Z   (I) wherein: n is 0 or 1, W represents —CO— or S(O)r wherein r is 0, 1 or 2, Z represents a group selected from aryl, arylalkyl, heteroaryl and heteroarylalkyl, each optionally substituted, R represents a grouping selected from: Z1—T—CO—, Z1—O—T—CO—, Z1—T—O—CO—, Z1—T—S(O)q— wherein Z1, T and q are as defined in the description, A represents alkylene, alkenylene or alkynylene each having from 3 to 8 carbon atoms, alkylenecycloalkylene, cycloalkylenealkylene, alkylenecycloalkylenealkylene, alkylenearylene, arylenealkylene, alkylenearylenealkylene a grouping wherein B1 is as defined in the description, or A forms with the adjacent nitrogen atom a grouping as defined in the description. Medicinal products containing the same are useful as Neuropeptide Y receptors ligands.
    Type: Grant
    Filed: June 23, 2000
    Date of Patent: August 7, 2001
    Assignee: Adir et Compagnie
    Inventors: Antonio Monge Vega, Ignacio Aldana Moraza, Daniel-Henri Caignard, Jacques Duhault, Jean Boutin, Odile Dellazuana
  • Patent number: 6245916
    Abstract: Compound of formula (I): wherein: n is 0 or 1, W represents —CO— or S(O)q and q is 0, 1 or 2, G represents a G1, G2, G3 or G4 group as defined in the description, Z represents alkyl, aryl, heteroaryl, arylalkyl, arylalkenyl, arylalkynyl, heteroarylalkenyl, heteroarylalkynyl or heteroarylalkyl each optionally substituted.
    Type: Grant
    Filed: April 14, 2000
    Date of Patent: June 12, 2001
    Assignee: Adir et Compagnie
    Inventors: Jean-Luc Fauchere, Jean-Claude Ortuno, Jacques Duhault, Jean Albert Boutin, Nigel Levens
  • Patent number: 6172108
    Abstract: Compounds of formula (I): R—NH—A—CO—NH—NH—(W)n—Z  (I) wherein: n is 0 or 1, W represents —CO— or S(O)r wherein r is 0, 1 or 2, Z represents a group selected from aryl, arylalkyl, heteroaryl and heteroarylalkyl, each optionally substituted, R represents a grouping selected from: Z1—T—CO—, Z1—O—T—CO—, Z1—T—O—CO—, Z1—T—S(O)q— wherein Z1, T and q are as defined in the description, A represents alkylene, alkenylene or alkynylene each having from 3 to 8 carbon atoms, alkylenecycloalkylene, cycloalkylenealkylene, alkylenecycloalkylenealkylene, alkylenearylene, arylenealkylene, alkylenearylenealkylene a grouping wherein B1 is as defined in the description, or A forms with the adjacent nitrogen atom a grouping as defined in the description, and medicinal products containing the same which are useful as Neuropeptide Y receptor
    Type: Grant
    Filed: December 16, 1999
    Date of Patent: January 9, 2001
    Assignee: Adir et Compagnie
    Inventors: Antonio Monge Vega, Ignacio Aldana Moraza, Daniel-Henri Caignard, Jacques Duhault, Jean Boutin, Odile Dellazuana
  • Patent number: 5506245
    Abstract: The compounds are 5-(4-substituted benzyl)thiazolidine-2,4-diones, enantiomers, diastereoisomers and pharmaceutically tolerable salts thereof, useful for treating conditions of insulin-resistance and/or non insulin-dependent diabetes.A compound disclosed is: .(R,S)-5-{4-[2-benzofuran-2-yl)carbonylamino)ethyl]benzyl}thiazolidine-2,4 -dione.
    Type: Grant
    Filed: January 19, 1995
    Date of Patent: April 9, 1996
    Assignee: ADIR et Compagnie
    Inventors: Gilbert Regnier, Yves Charton, Jacques Duhault, Joseph Espinal
  • Patent number: 5478853
    Abstract: The compounds are 5-(4-substituted benzyl)thiazolidine-2,4-diones, enantiomers, diastereoisomers and pharmaceutically tolerable salts thereof, useful for treating conditions of insulin-resistance and/or non insulin-dependent diabetes.A compound disclosed is: 5-{4-[2-(2-methoxy-5-chlorobenzamido)ethyl]benzyl}thiazolidine-2,4-dione.
    Type: Grant
    Filed: January 20, 1995
    Date of Patent: December 26, 1995
    Assignee: Adir et Compagnie
    Inventors: Gilbert Regnier, Yves Charton, Jacques Duhault, Joseph Espinal
  • Patent number: 5422365
    Abstract: A compound selected from those of formula (I): ##STR1## wherein: R.sub.1, R'.sub.1 and R.sub.2 are each selected, independently of the others, from hydrogen and an alkyl radical, the two R.sub.2 groups being in the cis position in relation to the rings,and R, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10, R'a and R'b are as defined in the description,useful therapeutically in the regulation of the secretion of insulin.
    Type: Grant
    Filed: August 12, 1994
    Date of Patent: June 6, 1995
    Assignee: Adir et Compagnie
    Inventors: David Billington, Francoise Perron-Sierra, Isabelle Picard, Jacques Duhault, Joseph Espinal
  • Patent number: 5385920
    Abstract: Compounds of formula (I): ##STR1## in which: R.sub.1 and R.sub.2, which are identical or different, represent a higher alkyl or higher alkenyl radical,R.sub.3 represents a pyridyl or pyrazinyl radical,their isomers and their addition salts with a pharmaceutically acceptable acid and medicaments for the reduction of plasma lipids containing the same.
    Type: Grant
    Filed: June 9, 1993
    Date of Patent: January 31, 1995
    Assignee: Adir et Compagnie
    Inventors: Alex Cordi, Jean-Michel Lacoste, Jacques Duhault, Joseph Espinal, Michelle Boulanger
  • Patent number: 5330999
    Abstract: Compounds of formula (I): ##STR1## in which: R represents any one of the groups defined in the description. Medicinal products.
    Type: Grant
    Filed: January 29, 1993
    Date of Patent: July 19, 1994
    Assignee: Adir et Compagnie
    Inventors: Guillaume de Nanteuil, Jacques Duhault, Denis Ravel, Yolande Herve
  • Patent number: 5296605
    Abstract: Compounds of formula (I): ##STR1## in which: R represents any one of the groups defined in the description used as medicinal products.
    Type: Grant
    Filed: January 29, 1993
    Date of Patent: March 22, 1994
    Assignee: Adir et Compagnie
    Inventors: Guillaume de Nanteuil, Jacques Duhault, Denis Ravel, Yolande Herve
  • Patent number: 5278154
    Abstract: Compounds of formula (I): ##STR1## in which: R.sub.1 or R.sub.4, which are identical or different, represent hydrogen or alkyl,R.sub.2 represents hydrogenm or alkyl, hydroxymethyl, --CH.sub.2 OPO(OH).sub.2 or --CH.sub.2 OPO(ONa).sub.2,R.sub.3 represents hydrogen, alkyl or hydroxyl or any one of the following groups: ##STR2## in which: T represents oxygen or sulfur,n represents an integer between 1 and 4,R.sub.5 represents hydrogen or alkyl,X represents nitrogen, CH or CR'.sub.3 (in which R'.sub.3 has the same meaning as R.sub.3 except in the case where R.sub.3 represents hydroxyl),A represents alkylene of formula --(CH.sub.2).sub.p --in which p represents an integer between 2 and 4, optionally substituted by one or more linear or branched (C.sub.1 -C.sub.
    Type: Grant
    Filed: December 31, 1992
    Date of Patent: January 11, 1994
    Assignee: Adir et Compagnie
    Inventors: Jean-Michel Lacoste, Jacques Duhault, Denis Ravel
  • Patent number: 5266591
    Abstract: The compounds are ethanolamine benzoate compounds useful for the treatment of syndrome X, and of hypertension in patients who are insulin resistant or have one or more metabolic anomalies.A compound disclosed is S-1-(m-trifluoromethylphenyl)-2-{.beta.-{4-[2-(N-(3,3-diphenylpropionyl)am ino)ethyl] benzoyloxy}ethylamino} propane.
    Type: Grant
    Filed: November 20, 1992
    Date of Patent: November 30, 1993
    Assignee: Adir et Compagnie
    Inventors: Michel Wierzbicki, Pierre Hugon, Jacques Duhault, Michelle Boulanger, Francoise Lacour
  • Patent number: 5266718
    Abstract: New ethanolamine benzoate compounds which can be used as medicaments and correspond to the formula: ##STR1## wherein R is as defined in the description, in the form of racemic compounds and enantiomers. These new compounds and their physiologically tolerable salts can be used therapeutically for treatment of insulin-resistance states.
    Type: Grant
    Filed: June 12, 1992
    Date of Patent: November 30, 1993
    Assignee: Adir et Compagnie
    Inventors: Michel Wierzbicki, Pierre Hugon, Jacques Duhault, Francoise Lacour, Michelle Boulanger
  • Patent number: 5266565
    Abstract: Compounds of formula (I): ##STR1## in which: R.sub.1 or R.sub.4, which are identical or different, represent hydrogen or alkyl,R.sub.2 represents hydrogenm or alkyl, hydroxymethyl, --CH.sub.2 OPO(OH).sub.2 or --CH.sub.2 OPO(ONa).sub.2,R.sub.3 represents hydrogen, alkyl or hydroxyl or any one of the following groups: ##STR2## in which: T represents oxygen or sulfur,n represents an integer between 1 and 4,R.sub.5 represents hydrogen or alkyl,X represents nitrogen, CH or CR'.sub.3 (in which R'.sub.3 has the same meaning as R.sub.3 except in the case where R.sub.3 represents hydroxyl),A represents alkylene of formula --(CH.sub.2).sub.p -in which p represents an integer between 2 and 4, optionally substituted by one or more linear or branched (C.sub.1 -C.sub.
    Type: Grant
    Filed: July 2, 1992
    Date of Patent: November 30, 1993
    Assignee: Adir et Compagnie
    Inventors: Jean-Michel Lacoste, Jacques Duhault, Denis Ravel
  • Patent number: 5266582
    Abstract: Compounds of formula (I): ##STR1## in which: R represents any one of the groups defined in the description.Medicinal products.
    Type: Grant
    Filed: August 14, 1992
    Date of Patent: November 30, 1993
    Assignee: Adir et Compagnie
    Inventors: Guillaume de Nanteuil, Jacques Duhault, Denis Ravel, Yolande Herve
  • Patent number: 5173491
    Abstract: 1,3,7-trimethyl-8-[3-(4-diethylaminocarbonyl-piperazino) propyl] xanthine and physiologically tolerable acid addition salts thereof may be used for the preparation of medicaments for the treatment of memory disorders, intellectual disorders of ageing, and Alzheimer's disease.
    Type: Grant
    Filed: September 20, 1990
    Date of Patent: December 22, 1992
    Assignee: Adir et Compagnie
    Inventors: Annie Kamoun, Elisabeth Mocaer, Gilbert Regnier, Claude Guillonneau, Jacques Duhault
  • Patent number: 5079245
    Abstract: The compounds 2-trifluoromethyl-7-substituted-6,7,8,9-tetrahydro-[5H]-benzocycloheptenes are disclosed and disclosed to be useful in the treatment of metabolic illnesses such as diabetes, obesity, and their complications. A perferred compound is 2-trifluoromethyl-7-amino-6,7,8,9-tetrahydro-[5H-benzocycloheptane.
    Type: Grant
    Filed: July 5, 1989
    Date of Patent: January 7, 1992
    Assignee: Adir et Compagnie
    Inventors: Michel Wierzbicki, Pierre Hugon, Jacques Duhault, Francoise Lacour
  • Patent number: 4999372
    Abstract: New aminochromanol compounds of the formula: ##STR1## in which X is cyano, nitro, trifluoromethyl, alkoxycarbonyl, carbamido, dialkylcarbamido, aminosulfonyl, dialkylaminosulfonyl, alkylsulfonyl, alkylsulfonylamino or acyl;CH.sub.2 -R is attached (in the 5 position of the pyrrolidinone nucleus) to an R- or S-configured carbon atom, and R is:either OR' or SR' in which R' is hydrogen, (C.sub.1 -C.sub.10)-alkyl, (C.sub.1 -C.sub.5 -alkyl)-carbonyl or ##STR2## and physiologically tolerable acid addition salts thereof, in the case where R contains a basic function.These compounds and their physiologically tolerable salts can be used in therapeutics for the activation of potassium channels, especially in the treatment of disorders associated with abnormal smooth muscle contraction and in the cardiovascular, bronchopulmonary, digestive, urinary and uterine fields.
    Type: Grant
    Filed: October 11, 1989
    Date of Patent: March 12, 1991
    Assignee: ADIR et Compagnie
    Inventors: Gilbert Regnier, Alain Dhainaut, Jean-Paul Vilaine, Nicole Villeneuve, Ghislaine Joly, Jacques Duhault
  • Patent number: 4970301
    Abstract: Compound of general formula I: ##STR1## in which: A is a single or double bond,R.sub.1 and R.sub.3, which may be identical or different, are each a hydrogen atom, an alkoxycarbonylmethylene radical of formula --CH.sub.2 CO.sub.2 R.sub.4 (in which R.sub.4 denotes an alkyl radical having 1 to 5 carbon atoms) or a radical of formula W: ##STR2## (in which n is equal to 0 or 1 and R.sub.5, R.sub.6 and R.sub.7, which may be identical or different, are each a hydrogen or halogen atom, a hydroxyl radical, a trifluoromethyl radical, a lower alkyl radical containing 1 to 5 carbon atoms or an alkoxy radical containing 1 to 5 carbon atoms),R.sub.2 is a hydrogen atom, an alkoxycarbonylmethylene radical of formula --CH.sub.2 CO.sub.2 R.sub.4, a radical of formula W, or a .beta.-glucose or rutinose molecule linked to the oxygen to which it is attached with a glycoside bond,on condition, however, that at least either R.sub.1 or R.sub.2 or R.sub.
    Type: Grant
    Filed: November 29, 1988
    Date of Patent: November 13, 1990
    Assignee: Adir et Cie
    Inventors: Yves Rolland, Jacques DuHault