Abstract: A re-wearable physiological monitoring device includes a reusable component and a disposable component. The reusable component includes an electronics module and a latching system for latching the reusable component to the disposable component. The disposable component includes an adhesive patch to be adhered to a user's skin, two electrodes to receive electrical signals from the user's skin, a cradle for the reusable component to be latched on, and a battery to power the device. The disposable component may include a “battery disconnect switch” for disconnecting the battery when the reusable component is not latched on; a gasket for isolating each contact between the reusable component and the disposable component in a waterproof enclosure; and a printed contact within the disposable component that is resistant to scratching.

Abstract: A fetal and maternal monitoring system is provided, including one or more sensing devices, a central control device which receives signals from, and provides power to, the sensing devices, and a gateway device in wireless communication with the central control device for visualization of data received from the central control device and transmission of the received data to a remote location over a network. The one or more sensing devices may include a fetal heart rate monitor (FHR), a strain gauge tocodynamometer (TOCO), maternal heart rate monitor (MHR), blood pressure monitor or other wearable health or fitness sensing device which require only a basic sensor and rely upon the central control device for processing and power. Lighting elements on the sensing devices provide indications of signal detection and strength. The gateway device will also provide instructions to a user for performing tests and virtual physician visits.

Abstract: Techniques for acquiring and analyzing M-FISH images in a manner that allows for proper image registration; and techniques for combining a plurality of registered images to provide labeled images. Epi-illumination embodiments use multiple filter cubes for different subsets of the entire set of desired dyes. The registration problem is addressed by configuring the different multiband cubes so that pairs of cubes have a common dye for which they are configured. Accordingly, a first set of images generated with a first cube includes an image that corresponds to (contains the same features as) one of the images in a second set of images generated with a second cube. This allows the first set of images to be precisely and accurately aligned with the second set of images. A method for generating a labeled image typically includes a normalization of the pixel intensities within each image, followed by a transformation to ratio images.

Abstract: Techniques for acquiring and analyzing M-FISH images in a manner that allows for proper image registration; and techniques for combining a plurality of registered images to provide labeled images. Epi-illumination embodiments use multiple filter cubes for different subsets of the entire set of desired dyes. The registration problem is addressed by configuring the different multiband cubes so that pairs of cubes have a common dye for which they are configured. Accordingly, a first set of images generated with a first cube includes an image that corresponds to (contains the same features as) one of the images in a second set of images generated with a second cube. This allows the first set of images to be precisely and accurately aligned with the second set of images. A method for generating a labeled image typically includes a normalization of the pixel intensities within each image, followed by a transformation to ratio images.

Abstract: In an automatic focusing system an element (2) is inserted in the path of a beam of light (3) directed towards a sensor array. The element comprises a transparent material or predetermined reflective index, the element presenting a first region (4) of a first thickness and another region (5) of a greater thickness. The image falling on to the sensor comprises three areas--one area where the light has passed through the one region and another area where the light has passed through the further region and yet another area. The automatic focusing system derives signals from two of the areas and processes the signals so that the image is in focus in the third area.