Patents by Inventor Jacques Gosteli
Jacques Gosteli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4692442Abstract: The invention relates to 2-penem-3-carboxylic acid compounds of the formula ##STR1## in which R.sub.a represents an organic radical bonded by a carbon atom to the ring carbon atom, a free, etherified or esterified hydroxy or mercapto group or a halogen atom, R.sub.1 represents hydrogen, an organic radical bonded by a carbon atom to the ring carbon atom, or an etherified mercapto group, and R.sub.2 represents a hydroxy group or an R.sub.2.sup.A radical that together with the carbonyl grouping --C(.dbd.O)-- forms a protected carboxyl group, and to salts of such compounds with salt-forming groups, processes for the manufacture of such compounds, pharmaceutical preparations containing compounds of the formula I with pharmacological properties, and their use. The compounds have antibiotic activity.Type: GrantFiled: November 18, 1980Date of Patent: September 8, 1987Assignee: Ciba-Geigy CorporationInventors: Jacques Gosteli, Ivan Ernest, Marc Lang, Robert B. Woodward
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Patent number: 4692543Abstract: Process for the production of optically-active di-[3-chloro-2-oxy-propyltrimethylammonium]-tartrate. Racemic 3-chloro-2-oxy-propyltrimethylammonium-chloride is converted by racemate resolution with CaCl.sub.2, for example, into the optically-active di-[3-chloro-2-oxy-propyltrimethylammonium]-tartrate. Such optically-active tartrate compound is dissociated into calcium tartrate and optically-active 3-chloro-2-oxy-propyltrimethylammonium-chloride, and the latter is converted with inorganic cyanides. From the product, the production of optically-active carnitine nitrile chloride can be achieved.Type: GrantFiled: February 25, 1986Date of Patent: September 8, 1987Assignee: Lonza Ltd.Inventors: Leander Tenud, Jacques Gosteli
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Patent number: 4670192Abstract: Process for the production of optically-active di-[3-chloro-2-hydroxy-propyltrimethylammonium]-tartrate. Racemic 3-chloro-2-hydroxy-propyltrimethylammonium-chloride is converted by racemate resolution with optically-active tartaric acid into the optically-active di-[3-chloro-2-hydroxy-propyltrimethylammonium]-tartrate. Such optically-active tartrate compound is dissociated in tartaric acid and optically-active 3-chloro-2-hydroxy-propyltrimethylammonium-chloride and the latter is converted with inorganic cyanides. From the product, the production of optically-active carnitine nitrile chloride can be achieved.Type: GrantFiled: June 24, 1986Date of Patent: June 2, 1987Assignee: Lonza Ltd.Inventors: Leander Tenud, Jacques Gosteli
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Patent number: 4524028Abstract: 2-Penem-3-carboxylic acid compounds of the formula ##STR1## in which R.sub.1 represents hydrogen, an organic radical bonded by a carbon atom to the ring carbon atom or an etherified mercapto group andR.sub.2 represents hydroxy or a radical R.sub.2.sup.A forming together with the carbonyl grouping --C(.dbd.O)-- a protected carboxyl group,1-oxides thereof, as well as salts of such compounds having salt-forming groups, in racemic and optically active form, processes for their preparation, pharmaceutical compositions containing such compounds, and their use as antibiotics, and intermediates and their processes which are useful in the production of the compounds of the formula I.Type: GrantFiled: September 24, 1982Date of Patent: June 18, 1985Assignee: Ciba-Geigy CorporationInventors: Jacques Gosteli, Ivan Ernest, Robert B. Woodward
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Patent number: 4518533Abstract: 2-Penem-3-carboxylic acid compounds of the formula ##STR1## in which R.sub.1 represents hydrogen, an organic radical bonded by a carbon atom to the ring carbon atom or an etherified mercapto group andR.sub.2 represents hydroxy or a radical R.sub.2.sup.A forming together with the carbonyl grouping --C(.dbd.O)--a protected carboxyl group,1-oxides thereof, as well as salts of such compounds having salt-forming groups, in racemic and optically active form, processes for their preparation, pharmaceutical compositions containing such compounds, and their use as antibiotics, and intermediates and their processes which are useful in the production of the compounds of the formula I.Type: GrantFiled: September 24, 1982Date of Patent: May 21, 1985Assignee: Ciba Geigy CorporationInventors: Jacques Gosteli, Ivan Ernest, Robert B. Woodward
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Patent number: 4515717Abstract: 2-Penem-3-carboxylic acid compounds of the formula ##STR1## in which R.sub.1 represents hydrogen, an organic radical bonded by a carbon atom to the ring carbon atom or an etherified mercapto group andR.sub.2 represents hydroxy or a radical R.sub.2.sup.A forming together with the carbonyl grouping --C(.dbd.O)-- a protected carboxyl group,1-oxides thereof, as well as salts of such compounds having salt-forming groups, in racemic and optically active form, processes for their preparation, pharmaceutical compositions containing such compounds, and their use as antibiotics, and intermediates and their processes which are useful in the production of the compounds of the formula I.Type: GrantFiled: September 24, 1982Date of Patent: May 7, 1985Assignee: Ciba Geigy CorporationInventors: Jacques Gosteli, Ivan Ernest, Robert B. Woodward
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Patent number: 4500457Abstract: 2-Penem-3-carboxylic acid compounds of the formula ##STR1## in which R.sub.1 represents hydrogen, an organic radical bonded by a carbon atom to the ring carbon atom or an etherified mercapto group andR.sub.2 represents hydroxy or a radical R.sub.2.sup.A forming together with the carbonyl grouping --C(.dbd.O)-- a protected carboxyl group,1-oxides thereof, as well as salts of such compounds having salt-forming groups, in racemic and optically active form, processes for their preparation, pharmaceutical compositions containing such compounds, and their use as antibiotics, and intermediates and their processes which are useful in the production of the compounds of the formula I.Type: GrantFiled: March 1, 1982Date of Patent: February 19, 1985Assignee: Ciba-Geigy CorporationInventors: Jacques Gosteli, Ivan Ernest, Robert B. Woodward
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Patent number: 4447360Abstract: 2-Penem-3-carboxylic acid compounds of the formula ##STR1## in which R.sub.1 represents hydrogen, an organic radical bonded by a carbon atom to the ring carbon atom or an etherified mercapto group andR.sub.2 represents hydroxy or a radical R.sub.2.sup.A forming together with the carbonyl grouping --C(.dbd.O)-- a protected carboxyl group,1-oxides thereof, as well as salts of such compounds having salt-forming groups, in racemic and optically active form, processes for their preparation, pharmaceutical compositions containing such compounds, and their use as antibiotics, and intermediates and their processes which are useful in the production of the compounds of the formula I.Type: GrantFiled: December 8, 1980Date of Patent: May 8, 1984Assignee: Ciba-Geigy CorporationInventors: Jacques Gosteli, Ivan Ernest, Robert B. Woodward
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Patent number: 4430510Abstract: The present invention relates to a novel process for the preparation of 2-(2,4-dichlorophenoxy)-phenylacetic acid a compound having useful anti-inflammatory properties. The process comprises reacting a 2-halo-phenylacetic acid or a salt thereof under basic conditions in the presence of metallic copper with 2,4-dichlorophenol or a salt thereof.Type: GrantFiled: May 24, 1982Date of Patent: February 7, 1984Assignee: Schering CorporationInventor: Jacques Gosteli
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Patent number: 4396621Abstract: Oxothia compounds, especially 2-oxo-2,3-dihydro-benzo[b]-thiophene compounds of the formula ##STR1## in which Ph represents an optionally substituted 1,2-phenylene radical, X represents oxygen or sulphur, R.sub.1 represents an organic radical bonded via a carbon atom and R.sub.2 denotes hydrogen or an optionally substituted hydrocarbon radical of aliphatic character, and their salts are useful as peripheral analgetics and/or as antiphlogistic uricosuric and/or thrombolytic agents.Type: GrantFiled: November 7, 1980Date of Patent: August 2, 1983Assignee: Ciba-Geigy CorporationInventors: Raymond Bernasconi, Pier G. Ferrini, Richard Goschke, Jacques Gosteli
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Patent number: 4364865Abstract: The invention relates to 6-amino-2-penem-3-carboxylic acid compounds of the formula ##STR1## in which R.sub.1.sup.a denotes hydrogen or an amino protective group R.sub.1.sup.A and R.sub.1.sup.b represents hydrogen or an acyl radical Ac, or in which R.sub.1.sup.a and R.sub.1.sup.b conjointly form a bivalent amino protective group, R.sub.2 denotes hydroxyl or a radical R.sub.2.sup.A which, together with the carbonyl grouping --C(.dbd.O)--, forms a protected carboxyl group, and R.sub.3 represents hydrogen or an organic radical which is linked via a carbon atom to the ring carbon atom, and 1-oxides thereof, as well as salts of such compounds having salt-forming groups, which compounds possess antibiotic properties, processes for the manufacture of such compounds, and also pharmaceutical formulations containing compounds of the formula I with pharmacological properties, and the use thereof, either as antibiotics, preferably in the form of pharmaceutical formulations, or as intermediate products.Type: GrantFiled: June 11, 1980Date of Patent: December 21, 1982Assignee: Ciba-Geigy CorporationInventors: Ivan Ernest, Jacques Gosteli, Robert B. Woodward
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Patent number: 4331676Abstract: 2-Penem-3-carboxylic acid compounds of the formula ##STR1## in which R.sub.1 represents hydrogen, an organic radical bonded by a carbon atom to the ring carbon atom or an etherified mercapto group andR.sub.2 represents hydroxy or a radical R.sub.2.sup.A forming together with the carbonyl grouping --C(.dbd.O)-- a protected carboxyl group, 1-oxides thereof, as well as salts of such compounds having salt-forming groups, in racemic and optically active form, processes for their preparation, pharmaceutical compositions containing such compounds, and their use as antibiotics, and intermediates and their processes which are useful in the production of the compounds of the formula I.Type: GrantFiled: May 4, 1978Date of Patent: May 25, 1982Assignee: Ciba-Geigy CorporationInventors: Jacques Gosteli, Ivan Ernest, Robert B. Woodward
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Patent number: 4320138Abstract: Oxothia compounds, especially 2-oxo-2,3-dihydro-benzo[b]-thiophene compounds of the formula ##STR1## in which Ph represents an optionally substituted 1,2-phenylene radical, X represents oxygen or sulphur, R.sub.1 represents an organic radical bonded via a carbon atom and R.sub.2 denotes hydrogen or an optionally substituted hydrocarbon radical of aliphatic character, and their salts are useful as peripheral analgetics and/or as antiphlogistic uricosuric and/or thrombolytic agents.Type: GrantFiled: December 8, 1980Date of Patent: March 16, 1982Assignee: Ciba-Geigy CorporationInventors: Raymond Bernasconi, Pier G. Ferrini, Richard Goschke, Jacques Gosteli
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Patent number: 4260779Abstract: Oxothia compounds, especially 2-oxo-2,3-dihydro-benzo[b]thiophene compounds of the formula ##STR1## in which Ph represents an optionally substituted 1,2-phenylene radical, X represents oxygen or sulphur, R.sub.1 represents an organic radical bonded via a carbon atom and R.sub.2 denotes hydrogen or an optionally substituted hydrocarbon radical of aliphatic character, and their salts are useful as peripheral analgetics and/or as antiphlogistic uricosuric and/or thrombolytic agents.Type: GrantFiled: November 9, 1979Date of Patent: April 7, 1981Assignee: Ciba-Geigy CorporationInventors: Raymond Bernasconi, Pier G. Ferrini, Richard Goschke, Jacques Gosteli
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Patent number: 4249027Abstract: According to the present invention, 5-substituted resorcinols of the formula I ##STR1## wherein R.sub.1 represents a hydrocarbon radical, optionally unsubstituted or substituted by inert substituents, are prepared by reacting a carboxylic acid ester of the formula IIR.sub.1 --C.tbd.C--CO--O--R.sub.2 (II)wherein R.sub.2 represents a non-aromatically bound lower hydrocarbon radical, in the presence of an alkaline condensation agent, with a diester of 3-oxoglutaric acid of the formula IIIR.sub.3 --O--CO--CH.sub.2 --CO--CH.sub.2 --CO--O--R.sub.4 (III)wherein R.sub.3 and R.sub.4 represent non-aromatically bound lower hydrocarbon radicals; hydrolyzing the resulting dihydroxyisophthalic acid acid ester of the formula IV ##STR2## and decarboxylating the hydrolyzed product, a specific embodiment is the preparation of 5-pentylresorcinol.Type: GrantFiled: November 1, 1976Date of Patent: February 3, 1981Assignee: Ciba-Geigy CorporationInventor: Jacques Gosteli
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Patent number: 4213920Abstract: A process for the production of benzaldehydes which are substituted in the ortho-position by an electrophilic group R, which comprises brominating an ortho-substituted compound of the formula I ##STR1## in which R represents the nitro group, the cyano group, an alkoxy group of 1 to 8 carbon atoms or a halogen atom, under irradiation with visible light in an inert solvent, to give the bromide of the formula II ##STR2## converting the resulting bromide by treatment with an alkali bromide in an inert solvent into a styrene compound of the formula III ##STR3## and ozonising this latter compound in an inert solvent to give the compound of the formula IV ##STR4##Type: GrantFiled: June 28, 1978Date of Patent: July 22, 1980Assignee: Ciba-Geigy CorporationInventor: Jacques Gosteli
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Patent number: 4206152Abstract: The present invention provides a process for the production of unsubstituted or substituted o-phthalaldehydes by hydrolysis of .alpha.,.alpha., .alpha.',.alpha.'-tetrahalogeno-o-xylenes with a carboxylate in an aqueous medium in the presence of a phase transfer catalyst and an organic base.Type: GrantFiled: December 21, 1978Date of Patent: June 3, 1980Assignee: Ciba-Geigy CorporationInventor: Jacques Gosteli
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Patent number: 4165268Abstract: A process for the production of benzal bromides which contain an electrophilic substituent in the ortho- and/or para-position of the formula (Ia), or of mixtures thereof with the corresponding benzyl bromides of the formula (Ib), ##STR1## IN WHICH R represents an electrophilic substituent in the ortho- and/or para position, by treating correspondingly substituted toluenes with elementary bromine under irradiation with visible light in a two-phase system which consists of an aqueous and an organic phase, which process comprises carrying out the reaction in the presence of a base.Type: GrantFiled: October 31, 1977Date of Patent: August 21, 1979Assignee: Ciba-Geigy AGInventors: Franz Marti, Tibor Somlo, Jacques Gosteli
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Patent number: 4151170Abstract: A process for the manufacture of indigoid dyes, wherein a functional derivative of the anthranilic acid of the general formula I ##STR1## in which A completes a mono- or polynuclear, substituted or unsubstituted aromatic ring,X represents a hydrogen atom or a protective group for the free amino group which can form an anhydro derivative with the carboxyl group in the ortho-position,Is reacted with nitromethane in the presence of a base or with a salt of nitroacetic acid to give the .omega.-nitro-o-amino-acetophenone derivative of the general formula II ##STR2## in which A and X are as defined in formula I, and this intermediate is condensed by heating with acids to give the indigo compound of the general formula III ##STR3## in which A is as defined in formula I.Type: GrantFiled: December 16, 1976Date of Patent: April 24, 1979Assignee: Ciba-Geigy AGInventor: Jacques Gosteli
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Patent number: 4138451Abstract: Thioformamidophosphono-acetates are prepared by reacting an isocyano compound of the formula C.dbd.N--CH.sub.2 --X.sub.1 in the presence of a base with a compound of the formula R.sub.o --X.sub.2, in which compounds one of the groups X.sub.1 and X.sub.2 represents a protected carboxyl group of the formula --C(.dbd.O)--OR.sub.1 and the other a disubstituted phosphono group of the formula --P(.fwdarw.O) (OR).sub.2, and wherein R.sub.o represents a reactive etherified or esterified hydroxyl group, and adding hydrogen sulphide on to the isocyano group of the phosphono-isocyano-acetate formed as an intermediate.Type: GrantFiled: April 28, 1977Date of Patent: February 6, 1979Assignee: Ciba-Geigy CorporationInventor: Jacques Gosteli