Abstract: The present invention provides a compound, or a pharmaceutically acceptable salt thereof, of formula (I): wherein R1, R2, R3, R4, R5, R26, R27, y, R, M, W, L, V, T, Y, J, K and A are as described herein, therapeutic uses of said compounds, uses of said compounds as research chemicals, a pharmaceutical composition and combinations comprising said compounds, and methods for manufacturing the compounds of the invention.

Abstract: The present invention provides a compound, or a pharmaceutically acceptable salt thereof, of formula (I): wherein R1, R2, R3, R4, R5, R26, R27, y, R, M, W, L, V, T, Y, J, K and A are as described herein, therapeutic uses of said compounds, uses of said compounds as research chemicals, a pharmaceutical composition and combinations comprising said compounds, and methods for manufacturing the compounds of the invention.

Abstract: A digital seismic sensor adapted to be connected, via a two-conductor line, to an acquisition device. The digital seismic sensor includes: a digital sensor; a local sampling clock providing a sampling frequency; a receiver for receiving command data coming from the acquisition device and synchronization information providing accurate timing information to enable seismic sensor synchronization; a compensator for compensating, as a function of the synchronization information, a drift of the local sampling clock; a transmitter for transmitting seismic data towards the acquisition device; a driver for driving the receiver and the transmitter, according to a half-duplex transmission protocol over the two-conductor line and using a transmission clock extracted from the received command data; a power receiver for receiving electrical power; and a coupler for coupling the command and synchronization information receiver, the transmitter and the power receiver to the two-conductor line.

Abstract: A digital seismic sensor adapted to be connected, via a two-conductor line, to an acquisition device. The digital seismic sensor includes: a digital sensor; a local sampling clock providing a sampling frequency; a receiver for receiving command data coming from the acquisition device and synchronization information providing accurate timing information to enable seismic sensor synchronization; a compensator for compensating, as a function of the synchronization information, a drift of the local sampling clock; a transmitter for transmitting seismic data towards the acquisition device; a driver for driving the receiver and the transmitter, according to a half-duplex transmission protocol over the two-conductor line and using a transmission clock extracted from the received command data; a power receiver for receiving electrical power; and a coupler for coupling the command and synchronization information receiver, the transmitter and the power receiver to the two-conductor line.

Abstract: A digital seismic sensor adapted to be connected, via a two-conductor line, to an acquisition device. The digital seismic sensor includes: a digital sensor; a local sampling clock providing a sampling frequency; a receiver for receiving command data coming from the acquisition device and synchronization information providing accurate timing information to enable seismic sensor synchronization; a compensator for compensating, as a function of the synchronization information, a drift of the local sampling clock; a transmitter for transmitting seismic data towards the acquisition device; a driver for driving the receiver and the transmitter, according to a half-duplex transmission protocol over the two-conductor line and using a transmission clock extracted from the received command data; a power receiver for receiving electrical power; and a coupler for coupling the command and synchronization information receiver, the transmitter and the power receiver to the two-conductor line.

Abstract: A method for harvesting seismic data and generating seismic output files from the seismic data and corresponding source data. The method includes: positioning, in a survey area, data acquisition units associated with sensors; performing at least one seismic event using at least one seismic source; acquiring seismic data in the data acquisition units, the seismic data resulting from the at least one seismic event; deploying at least two data harvester units at fixed positions in the survey area. Each data harvester unit: harvests the seismic data; receives source data relating to the seismic event; generates a partial seismic output file from the harvested seismic data and the received source data; transmits the partial seismic output file to a central unit. The method also comprises generating, by the central unit, a final seismic output file from the partial seismic output files transmitted by the at least two data harvester units.

Abstract: A digital seismic sensor adapted to be connected, via a two-conductor line, to an acquisition device. The digital seismic sensor includes: a digital sensor; a local sampling clock providing a sampling frequency; a receiver for receiving command data coming from the acquisition device and synchronization information providing accurate timing information to enable seismic sensor synchronization; a compensator for compensating, as a function of the synchronization information, a drift of the local sampling clock; a transmitter for transmitting seismic data towards the acquisition device; a driver for driving the receiver and the transmitter, according to a half-duplex transmission protocol over the two-conductor line and using a transmission clock extracted from the received command data; a power receiver for receiving electrical power; and a coupler for coupling the command and synchronization information receiver, the transmitter and the power receiver to the two-conductor line.

Abstract: The invention relates to a device, a method and an apparatus for acquiring data, the device comprising a wireless network including a set of nodes (100), each node (100) including a sender (140) and a receiver (150) for sending and/or receiving and/or relaying data and/or commands, and a satellite positioning system (130), characterized in that each satellite positioning system (130) includes means for providing specific data used for time-stamping the data relative to a common time reference, organizing an access to the wireless network in a perfectly controlled manner, and routing data and/or commands within the network.

Abstract: The invention relates to a device, a method and an apparatus for acquiring data, the device comprising a wireless network including a set of nodes (100), each node (100) including a sender (140) and a receiver (150) for sending and/or receiving and/or relaying data and/or commands, and a satellite positioning system (130), characterized in that each satellite positioning system (130) includes means for providing specific data used for time-stamping the data relative to a common time reference, organizing an access to the wireless network in a perfectly controlled manner, and routing data and/or commands within the network.

Abstract: A tricyclic compound of Formula (I): wherein: R1 is hydrogen or hydroxy; R2 is hydrogen or hydroxy; or R1 and R2 together are oxygen; A is a bond, CH2, CH CH3, CH2 CH2 or C(CH3)2; R3 and R4 are the same or different and are hydrogen, halo, C1-C6 alkyl, C1-C4 alkoxy, trifluoromethyl NO2, COR6, COOR6 or NR6R7, wherein R6 and R7 are the same or different and are hydrogen, C1-C6 alkyl or benzyl; R5 is hydrogen, C1-6 alkyl, C2-6 alkenyl, C3-6 cycloalkyl, (O═C)—C1-6 alkyl, (O═C)—C2-6 alkenyl, (O═C)—C3-6 cycloalkyl wherein said alkyl, alkenyl and cycloalkyl groups can be substituted by 1, 2 or 3 groups selected from halo, C3-C6 cycloalkyl, phenyl or substituted phenyl, and salts thereof, are particularly useful for treating, among other indications, neuropathic pain and other CNS disorders.

Abstract: The invention relates to the use of trimebutine [2-dimethylamino-2-phenylbutyl-3,4,5-trimethoxy-benzoate hydrogen maleate] or its corresponding stereoisomers for the preparation of a medicament to prevent and/or treat inflammatory somatic pain as well as chronic pain.

Abstract: The invention provides a combination of of trimebutine [2-dimethylamino-2-phenylbutyl-3, 4, 5-trimethoxy-benzoate hydrogen maleate] or its corresponding stereoisomers with an opioid analgesic for the preparation of a medicament to prevent and/or treat pain or nociception.

Abstract: The invention relates to the use of trimebutine [2-dimethylamino-2-phenylbutyl-3,4,5-trimethoxy-benzoate hydrogen maleate] or its corresponding stereoisomers for the preparation of a medicament to prevent and/or treat inflammatory somatic pain as well as chronic pain.

Abstract: The invention relates to the use of trimebutine [2-dimethylamino-2-phenylbutyl-3,4,5-trimethoxy-benzoate hydrogen maleate] or its corresponding stereoisomers for the preparation of a medicament to prevent and/or treat arthritis, osteo-traumatic pain, and neuralgias.

Abstract: The invention concerns novel phenylcyclidine derivatives with selective affinity for low affinity receptors, methods for preparing them, pharmaceutical compositions containing them and their use as protective agents for central or peripheral nervous system cells against acute or chronic degeneration, or as an anticonvulsant.