Abstract: The present invention is directed to a 3D-printed tire segment model having a tread portion comprising a plurality of grooves, ribs and/or tread blocks, and a plurality of blades extending out of the ribs and/or tread blocks, wherein the tire segment model is made of a 3D-printed polymer. Moreover, the present invention is drawn to a method of making a tire mold segment, including the step of 3D-printing the above tire segment model with a polymer.

Abstract: A system and method for monitoring configuration status of a plurality of network components of a network. The method comprises generating, based on a network object model, a first configuration file indicative of expected configuration status of the plurality of network components, the network model comprising Node objects, Interface objects, evpnEdge objects and Layer objects. The method further comprises receiving a second configuration file indicative of current configuration status of the plurality of network components, the first and second configuration files comprising tagged sections and sub-sections, and comparing the first and second configuration files comprising comparing a first sub-section of the first configuration file with a corresponding second sub-section of the second configuration file based on tags of the first and second sub-sections, the first and second sub-sections comprising configuration commands relative to one of the plurality of network components.

Abstract: The present disclosure relates, in general, to: (a) solid pharmaceutical dosage forms comprising acalabrutinib maleate; (b) methods of using such pharmaceutical dosage forms to treat B-cell malignancies and/or other conditions; (c) kits comprising such pharmaceutical dosage forms and, optionally, a second pharmaceutical dosage form comprising another therapeutic agent; (d) methods for the preparation of such pharmaceutical dosage forms; and (e) pharmaceutical dosage forms prepared by such methods.

Abstract: A system and method for monitoring configuration status of a plurality of network components of a network. The method comprises generating, based on a network object model, a first configuration file indicative of expected configuration status of the plurality of network components, the network model comprising Node objects, Interface objects, evpnEdge objects and Layer objects. The method further comprises receiving a second configuration file indicative of current configuration status of the plurality of network components, the first and second configuration files comprising tagged sections and sub-sections, and comparing the first and second configuration files comprising comparing a first sub-section of the first configuration file with a corresponding second sub-section of the second configuration file based on tags of the first and second sub-sections, the first and second sub-sections comprising configuration commands relative to one of the plurality of network components.

Abstract: A method and system of monitoring BGP-eVpn messages sent over a Mesh between a Point of Presence, POP, and a datacenter managed by an infrastructure provider in an Infrastructure provider network, including (i) receiving a BGP-eVpn message, at a Deployed network monitor connected to the Mesh, (ii) parsing by the Deployed network monitor the received BGP-eVpn message into Destination-type fields; and (iii) updating by the Deployed network monitor a Database representative of a per-tenant historical view of BGP-eVpn updates for a network deployed by or for a customer of the infrastructure provider in the Infrastructure provider network, based on a correlation between one or more of the parsed Destination-type fields and existing values in the Database entries.

Abstract: A method is devised of deploying a network configuration in a datacenter. The network configuration includes one of more points of interconnection, a point of presence of the datacenter being one of the one or more points of interconnection. Each of the one or more points of interconnection in the network configuration is modeled through objects comprising, for each given point of interconnection, a node object representing the point of interconnection, an interface object hierarchically inferior to the node object and representing a connection to the point of interconnection, an evpnEdge object representing the transport to/from of the point of interconnection in the network, and a layer object hierarchically inferior to the evpnEdge object, and representing the characteristics of the protocol of transport to/from the point of interconnection. The network configuration is set up by a succession of commands on the objects and then pushed to the datacenter.

Abstract: A data processing system to determine a risk factor of an impending transfer to the emergency department of an individual. The system includes a database which stores a plurality of status records for each person of a set of people. Each status record is dated and includes a list of monitoring indicators. Each indicator has a value chosen from a list of two predetermined values according to the status of the corresponding person. The system also a microprocessor to determine the risk factor by analyzing a plurality of status records of the individual, filled out according to the status of the individual, using a machine learning algorithm. The parameters of the algorithm being generated beforehand. A data processing method is further provided to determine a risk factor for an impending transfer of the individual to the emergency department.

Abstract: This disclosure relates to a portable multi-interface Braille key board cell system. The system includes a bump frame and a Braille keyboard module that are assembled together. The Braille keyboard module unit includes a Braille keyboard assembly integrated together with an extendable and retractable wing panel mechanism. The system is further in integration with a controller and a processing unit of a handheld device. The system can further access functions of the handheld device via Braille buttons or presser buttons provided by the Braille keyboard assembly.

Abstract: A method is devised of deploying a network configuration in a datacenter. The network configuration includes one of more points of interconnection, a point of presence of the datacenter being one of the one or more points of interconnection. Each of the one or more points of interconnection in the network configuration is modeled through objects comprising, for each given point of interconnection, a node object representing the point of interconnection, an interface object hierarchically inferior to the node object and representing a connection to the point of interconnection, an evpnEdge object representing the transport to/from of the point of interconnection in the network, and a layer object hierarchically inferior to the evpnEdge object, and representing the characteristics of the protocol of transport to/from the point of interconnection. The network configuration is set up by a succession of commands on the objects and then pushed to the datacenter.

Abstract: The present invention relates to a novel method for identifying pairs of receptors/ligands, transgenic animals useful for carrying out said method, and the use of ligands and/or modulators of the interaction between a ligand and its receptor in the food industry, fragrance industry, and health industry, for instance.

Abstract: This disclosure relates to a portable multi-interface Braille key board cell system. The system includes a bump frame and a Braille keyboard module that are assembled together. The Braille keyboard module unit includes a Braille keyboard assembly integrated together with an extendable and retractable wing panel mechanism. The system is further in integration with a controller and a processing unit of a handheld device. The system can further access functions of the handheld device via Braille buttons or preser buttons provided by the Braille keyboard assembly.

Abstract: The invention concerns a device and a process, the device being a cleaning device utilizing a dry chemical means assisted by plasma from a reactor (10) containing an unwanted deposit on its walls and at least one other polarizable surface (12), characterized in that it comprises means (13, 14) for positively polarizing one or each of the polarizable surfaces relative to the reactor walls maintained at a reference potential.

Abstract: The present invention relates to a novel method for identifying pairs of receptors/ligands, transgenic animals useful for carrying out said method, and the use of ligands and/or modulators of the interaction between a ligand and its receptor in the food industry, fragrance industry, and health industry, for instance.

Abstract: The invention relates to a protein construct, comprising (i) a targeting moiety that is capable of binding to a target cell, and (ii) an effector immunogenic moiety that is capable of triggering an existing, vaccine-induced or natural, immune response. The protein construct, that is preferably in the form of a heteromultimeric protein, is useful for redirecting an immune response that was pre-existing in a patient, toward an undesired target cell.

Abstract: A loudspeaker array is described including several circular sound emitters that are bunked. One circular sound emitter can be either a circular array of loudspeakers (kind 1) or a toroidal loudspeaker (kind 2) The loudspeaker array can be composed of circular sound emitters of kind 1, kind 2 or both. A toroidal loudspeaker is a loudspeaker whose membrane is annular and whose enclosure has a central hole. Both toroidal loudspeaker and circular array radiate mainly in their normal axis, i.e., perpendicular to the plane comprising the membrane or the loudspeakers. Circular sound emitters are arranged like an end-fire array so that all the circular sound emitter centers are on the same axis. Each circular sound emitter is driven by its own signal, which results from a filtered version of the input signal, allowing the sound to be focused in the radiation direction.

Abstract: The invention relates to a method for controlling and monitoring the level of confinement of the internal environment of a room, which includes determining the confinement index I from measurements of the CO2 content during a predetermined period, and reducing the level of confinement in accordance with the CO2 content. According to the invention, periods of occupancy of the internal environment are determined by means of at least one presence sensor provided with a calibration device which enables the sensor to react to the presence of humans as from an occupancy threshold. The invention also relates to a device configured in particular to calculate the confinement index I.

Abstract: The invention relates to a protein construct, comprising (i) a targeting moiety that is capable of binding to a target cell, and (ii) an effector immunogenic moiety that is capable of triggering an existing, vaccine-induced or natural, immune response. The protein construct, that is preferably in the form of a heteromultimeric protein, is useful for redirecting an immune response that was pre-existing in a patient, toward an undesired target cell.

Abstract: Compounds having the general formula II, III, or IV wherein R1 can be a radical of an optionally substituted C-4 to C-7 N-containing heterocycle or a radical of an optionally substituted cyclic or acyclic tertiary amine or isoindoline-1,3-dione: R2,3,4,5,6 can each independently be any one or combinations of the following moieties, cyano, nitro, acyl, alkyl, amido, azido, isothiocyanate, isocyanate, optionally substituted anilino, halogens, ethers, sulfonamides, thioacyl, nitro, aromatic, heterocyclic, olefinic, acetylene, deuterium, or tritium; Y can be either CH, CH2, O, S, OCH2, N—R, N—Ar, C—R, C—Ar; Z can be either H, O, S, S—R or NR.

Abstract: The invention relates to a protein construct, comprising (i) a targeting moiety that is capable of binding to a target cell, and (ii) an effector immunogenic moiety that is capable of triggering an existing, vaccine-induced or natural, immune response. The protein construct, that is preferably in the form of a heteromultimeric protein, is useful for redirecting an immune response that was pre-existing in a patient, toward an undesired target cell.

Abstract: A compound useful for treating subjects in need of therapy involving sigma receptors or for alleviation of affects resulting from drug abuse having the general formula I in which R1 can be a radical of an optionally substituted C-4 to C-7 N-containing heterocycle such as, for example, radicals of optionally substituted piperidines, optionally substituted piperazines, optionally substituted tetrahydropyridines, optionally substituted azepanes, tertiary amines (cyclic or acyclic), isoindoline-1,3-dione, or optionally substituted tetrahydroisoquinolones (aromatically substituted): R2,3,4,5,6 can each independently be any one or combinations of the following moieties, cyano, nitro, acyl, alkyl, amido, azido, isothiocyanate, isocyanate optionally substituted anilino, halogens, ethers, sulfonamides, thioacyl, nitro, aromatic, heterocyclic, olefinic, acetylene, deuterium, or tritium; Y can be either CH, CH2, O, S, OCH2, N—R, N—Ar, C—R, C—Ar; Z can be either H, O, S, S—R or NR.