Patents by Inventor Jacques Lux

Jacques Lux has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYSTEMIC INJECTION OF SUPERHEATED PERFLUOROCARBON EMULSION TO IMPROVE VENTILATION AND REDUCE VENTILATOR-INDUCED LUNG INJURY
    Publication number: 20250041332
    Abstract: Methods of treating or preventing a respiratory disease or condition in a subject in need thereof, inflating the lungs of a subject in need thereof, and reducing the positive-end expiratory pressure (PEEP) needed for mechanical ventilation, the methods comprising administering an effective amount of a composition comprising one or more perfluorocarbons to the subject.
    Type: Application
    Filed: September 13, 2022
    Publication date: February 6, 2025
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: ROBERT F. MATTREY, CAROLINE DE GRACIA LUX, JACQUES LUX
  • MICROBUBBLE-ASSISTED ULTRASOUND-GUIDED THERAPY
    Publication number: 20240269287
    Abstract: The innate immune sensing STING pathway has emerged as a potential therapeutic target to boost antitumor immune responses. STING resides in the cytoplasm, and its agonists, such as cGAMP, are dinucleotides that are difficult to deliver intracellularly. Disclosed herein is a microbubble-based platform (Microbubble (MB)-assisted UltraSound (US)-guided Immunotherapy of Cancer (MUSIC)) that can be used for targeted activation of STING, such as for treatment of primary and metastatic tumors.
    Type: Application
    Filed: April 12, 2022
    Publication date: August 15, 2024
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: SINA KHORSANDI, JACQUES LUX, WEN JIANG
  • POLYMER-CONJUGATED MICROBUBBLES FOR HIGH DRUG/GENE LOADING
    Publication number: 20240058470
    Abstract: Spermine-decorated microbubbles and methods of making the same as well as methods for using spermine-decorated microbubbles for drug delivery are described.
    Type: Application
    Filed: October 13, 2021
    Publication date: February 22, 2024
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: JACQUES LUX, SINA KHORSANDI, CAROLINE DE GRACIA LUX, ROBERT F. MATTREY
  • Microbubble and nanobubble expansion using perfluorocarbon nanodroplets for enhanced ultrasound imaging and therapy
    Patent number: 11763451
    Abstract: The disclosure describes imaging and therapy techniques comprising nanodroplets. More particularly, aspects of the disclosure relate to the use of nanodroplets to modify nanobubbles or microbubbles to provide improved imaging and/or therapeutic techniques and compositions.
    Type: Grant
    Filed: May 13, 2022
    Date of Patent: September 19, 2023
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Robert F. Mattrey, Caroline De Gracia Lux, Jacques Lux, Zhenghong Gao, Carlos J. Brambila
  • Bioresponsive particles
    Patent number: 11648297
    Abstract: Shielding enzymes are made by modifying the enzyme surface with silica precursors and then depositing silica to a desired thickness while retaining biological activity of the enzyme.
    Type: Grant
    Filed: June 2, 2019
    Date of Patent: May 16, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Jacques Lux, Robert F. Mattrey, Annie Y. Heble
  • NANODROPLETS WITH IMPROVED PROPERTIES
    Publication number: 20230039515
    Abstract: Stable perfluorocarbon nanodroplet compositions with properties such as low-boiling points and small particle diameters are provided for improved performance in ultrasound imaging and therapeutic applications. Methods of producing stabilized nanodroplet compositions and methods of using the compositions are further provided to allow for improved performance in ultrasound imaging techniques and/or therapeutic applications.
    Type: Application
    Filed: August 8, 2022
    Publication date: February 9, 2023
    Applicant: The Board of Regents of The University of Texas System
    Inventors: Caroline de Gracia Lux, Jacques Lux, Alexander M. Vezeridis, Robert F. Mattrey
  • MICROBUBBLE AND NANOBUBBLE EXPANSION USING PERFLUOROCARBON NANODROPLETS FOR ENHANCED ULTRASOUND IMAGING AND THERAPY
    Publication number: 20230005134
    Abstract: The disclosure describes imaging and therapy techniques comprising nanodroplets. More particularly, aspects of the disclosure relate to the use of nanodroplets to modify nanobubbles or microbubbles to provide improved imaging and/or therapeutic techniques and compositions.
    Type: Application
    Filed: May 13, 2022
    Publication date: January 5, 2023
    Applicant: The Board of Regents of The University of Texas System
    Inventors: Robert F. MATTREY, Caroline DE GRACIA LUX, Jacques LUX, Zhenghong GAO, Carlos J. BRAMBILA
  • Nanodroplets with improved properties
    Patent number: 11406722
    Abstract: Stable perfluorocarbon nanodroplet compositions with properties such as low-boiling points and small particle diameters are provided for improved performance in ultrasound imaging and therapeutic applications. Methods of producing stabilized nanodroplet compositions and methods of using the compositions are further provided to allow for improved performance in ultrasound imaging techniques and/or therapeutic applications.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: August 9, 2022
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Caroline de Gracia Lux, Jacques Lux, Alexander M. Vezeridis, Robert F. Mattrey
  • Microbubble and nanobubble expansion using perfluorocarbon nanodroplets for enhanced ultrasound imaging and therapy
    Patent number: 11334993
    Abstract: The disclosure describes imaging and therapy techniques comprising nanodroplets. More particularly, aspects of the disclosure relate to the use of nanodroplets to modify nanobubbles or microbubbles to provide improved imaging and/or therapeutic techniques and compositions.
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: May 17, 2022
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Robert F. Mattrey, Caroline De Gracia Lux, Jacques Lux, Zhenghong Gao, Carlos J. Brambila
  • MICROBUBBLE AND NANOBUBBLE EXPANSION USING PERFLUOROCARBON NANODROPLETS FOR ENHANCED ULTRASOUND IMAGING AND THERAPY
    Publication number: 20200320689
    Abstract: The disclosure describes imaging and therapy techniques comprising nanodroplets. More particularly, aspects of the disclosure relate to the use of nanodroplets to modify nanobubbles or microbubbles to provide improved imaging and/or therapeutic techniques and compositions.
    Type: Application
    Filed: February 24, 2020
    Publication date: October 8, 2020
    Inventors: Robert F. MATTREY, Caroline DE GRACIA LUX, Jacques LUX, Zhenghong GAO, Carlos J. BRAMBILA
  • Bioresponsive Particles
    Publication number: 20190367902
    Abstract: Shielding enzymes are made by modifying the enzyme surface with silica precursors and then depositing silica to a desired thickness while retaining biological activity of the enzyme.
    Type: Application
    Filed: June 2, 2019
    Publication date: December 5, 2019
    Applicant: Board of Regents, The University of Texas System
    Inventors: Jacques Lux, Robert F. Mattrey, Annie Y. Heble
  • Bioresponsive Particles
    Publication number: 20190365869
    Abstract: Shielding enzymes are made by modifying the enzyme surface with silica precursors and then depositing silica to a desired thickness while retaining biological activity of the enzyme.
    Type: Application
    Filed: June 1, 2019
    Publication date: December 5, 2019
    Applicant: Board of Regents, The University of Texas System
    Inventors: Jacques Lux, Robert F. Mattrey, Annie Yang
  • NANODROPLETS WITH IMPROVED PROPERTIES
    Publication number: 20180272012
    Abstract: Stable perfluorocarbon nanodroplet compositions with properties such as low-boiling points and small particle diameters are provided for improved performance in ultrasound imaging and therapeutic applications. Methods of producing stabilized nanodroplet compositions and methods of using the compositions are further provided to allow for improved performance in ultrasound imaging techniques and/or therapeutic applications.
    Type: Application
    Filed: March 16, 2018
    Publication date: September 27, 2018
    Inventors: Caroline de Gracia Lux, Jacques Lux, Alexander M. Vezeridis, Robert F. Mattrey