Abstract: The invention provides an essentially pure preparation of human adult astrocytes, and a method of producing same. The purified astrocytes are useful for the treatment of neurodegenerative disorders or trauma to the central nervous system.

Abstract: Recombinant adenoviruses comprising a heterologous DNA sequence coding for glial-derived neurotrophic factor (GDNF), preparation thereof, and use thereof for treating and/or preventing degenerative neurological diseases.

Abstract: The present invention relates to a defective adenovirus comprising at least a DNA sequence coding for all or an active part of glutathione peroxidase or a derivative thereof. It also relates to their utilisation in therapy and to the corresponding pharmaceutical compositions.

Abstract: The present invention is related to compositions and methods for the delivery of nucleic acids to neurons in a mammal, and uses thereof. The present invention specifically discloses the use of compounds that cause synaptic nerve sprouting to increase neuron retrograde transport of a vector or a product (a polypeptide or a nucleic acid for example) in a mammal. The invention is also based on the use of a compound that interacts with synaptosomal associated proteins to increase neuron retrograde transport of a vector or a product such as one cited above in a mammal. The invention also relates to a product comprising a viral vector comprising a transgene and a compound that causes synaptic nerve sprouting, for sequential use for delivering said transgene to neurons by retrograde transport and its uses for the preparation of a composition used as a treatment in several neurological disorders.

Abstract: The invention concerns a recombinant DNA vector characterized in that it is capable of directing the expression an/or transcription of a selected nucleotide sequence in the cells of the central nervous system and in that it comprises (i) at least part of the genome of an adenovirus, including the regions required for that adenovirus to penetrate into the cells normally infectable by that adenovirus and (ii) being inserted into said part of genome of an adenovirus under the control of a promoter, either present or also inserted into said genome part and operative in said cells. This recombinant vector finds particular use in the treatment of diseases of the central nervous system, also in gene therapy.

Abstract: The invention relates to a defective lentivirus which is pseudotyped with a lyssavirus envelope of the PV (rabies virus) or MOK type (Mokola virus), for example, and to the use thereof, especially in the preparation of a composition for in vivo transfer of genes in astrocytes and also for the treatment of disorders of the central nervous system.

Abstract: The invention concerns a novel method for treating motor neuron diseases and particularly amyotrophic lateral sclerosis. It consists more particularly in the systemic administration of expression systems of neurotrophic factors.

Abstract: Recombinant adenoviruses comprising a heterologous DNA sequence coding for basic blast growth factors (bFGF), preparation and uses thereof for the treatment and/or prevention of neurodegenerative diseases.

Abstract: The present invention relates to compositions and methods for nucleic acid analyses. More particularly, this invention provides compositions and methods for differential gene expression analyses on nucleic acid arrays. This invention discloses more preferably differential gene expression analyses on nucleic acid arrays using nucleic acid samples having distinct radioactive labels. Even more particularly, this invention relates to compositions and methods for nucleic acid analysis, comprising contacting at least two differently radiolabelled nucleic acid samples on a nucleic acid array, and detecting (or comparing or quantifying) hybrids formed between the nucleic acids of the samples and the nucleic acid array. The present invention can be used to detect or monitor gene expression or to compare gene expression (e.g., differential gene expression screening), for instance, and is suitable for use in research, diagnostic and many pharmacogenomics applications, for instance.

Abstract: The invention concerns human neural progenitor cells containing introduced genetic material encoding a product of interest, and their use for the treatment of neurodegenerative diseases.

Abstract: The invention provides a method of regenerating pancreas function in an individual by transplantation of an effective amount of functional pancreatic cells derived from embryonic pancreatic cells not older than 10 weeks of development. Also provided is the method of producing functional animal pancreatic cell, more precisely an immortalized human beta cell line. The invention also provides a method of treatment of diabetics. Also are provided pancreatic beta cells as a medicament to treat diabetics.

Abstract: The present invention relates to methods and compositions for delivering a nucleic acid to motor neurons administering the nucleic acid to muscle tissue. The invention relates to methods for treating pathologies of the nervous system, such as trauma and neurodegenerative diseases.

Abstract: The present invention relates to compositions and methods for genetic analyses. More particularly, this invention provides compositions and methods for differential gene expression analyses on biological material, such as tissue sections. This invention discloses more preferably differential gene expression analyses on biological material using particular probes with distinct radioactive labels. The present invention can be used to detect or monitor gene expression, compare gene expression (e.g., differential gene expression screening) in particular in different tissues, and is suitable for instance in research, diagnostic, and many pharmacogenomics applications.

Abstract: The present invention relates to methods and compositions for delivering nucleic acids to motor neurons by administering the nucleic acids to muscle tissue. The invention relates to methods for treating pathologies of the nervous system, such as trauma and neurodegenerative diseases.

Abstract: A defective recombinant adenovirus including at least one DNA sequence coding for all or an active part of a superoxide dismutase or a derivative thereof. The therapeutical use thereof and corresponding pharmaceutical compositions are also disclosed.

Abstract: The present invention concerns micro-arrays, their preparation and their uses. In particular, it concerns micro-arrays composed of nucleic acids immobilised on a support by means of arms in arborescent form and/or arms carrying a negative charge and/or directly on the supports carrying a negative charge. The methods and micro-arrays according to the present invention can be used for genetic expression detection or analysis, for research of genes of interest, or for diagnostic applications, for example.

Abstract: The present invention relates to methods and compositions for delivering nucleic acids to motor neurons by administering the nucleic acids to muscle tissue. The invention relates to methods for treating pathologies of the nervous system, such as trauma and neurodegenerative diseases.

Abstract: The invention concerns a recombinant DNA vector characterized in that it is capable of directing the expression an/or transcription of a selected nucleotide sequence in the cells of the central nervous system and in that it comprises (i) at least part of the genome of an adenovirus, including the regions required for that adenovirus to penetrate into the cells normally infectable by that adenovirus and (ii) being inserted into said part of genome of an adenovirus under the control of a promoter, either present or also inserted into said genome part and operative in said cells. This recombinant vector finds particular use in the treatment of diseases of the central nervous system, also in gene therapy.

Abstract: The invention discloses a new system for gene expression. The system is based in particular on the use of derived sequences of the first intron of the tyrosine hydroxylase gene having transcription enhancing properties. The system is particularly useful in the production of proteins in vitro, ex vivo or in vivo, particularly in gene therapy applications.

Abstract: Recombinant adenoviruses comprising a heterologous DNA sequence coding for glial-derived neurotrophic factor (GDNF), preparation thereof, and use thereof for treating and/or preventing degenerative neurological diseases.