Patents by Inventor Jacques R. Fresco

Jacques R. Fresco has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stabilization of triplexes by water structure-making substances
    Patent number: 6783932
    Abstract: The stability of a triplex in solution is enhanced by adding to the solution, either before or after formation of the triplex, an effective amount of either of the following: (a) a water structure-making substance, at an appropriately high concentration, other than an alkali or alkaline earth metal cation, a tetramethylammonium cation, or a polyamine; or (b) a combination of said water structure-making substance and an alkali or alkaline earth cation or a tetramethylammonium cation or a polyamine.
    Type: Grant
    Filed: July 2, 1999
    Date of Patent: August 31, 2004
    Assignee: Princeton University
    Inventors: Jacques R. Fresco, John Laurence Richard Lavelle
  • Triplex in-situ hybridization
    Patent number: 6461810
    Abstract: Disclosed are methods for detecting in situ the presence of a target sequence in a substantially double-stranded nucleic acid segment, which comprises: a) contacting in situ under conditions suitable for hybridization a substantially double-stranded nucleic acid segment with a detectable third strand, said third strand being capable of hybridizing to at least a portion of the target sequence to form a triple-stranded structure, if said target sequence is present; and b) detecting whether hybridization between the third strand and the target sequence has occured.
    Type: Grant
    Filed: September 8, 2000
    Date of Patent: October 8, 2002
    Assignee: Princeton University
    Inventors: Jacques R. Fresco, Marion D. Johnson
  • STABILIZATION OF TRIPLEXES BY WATER STRUCTURE-MAKING SUBSTANCES
    Publication number: 20020137919
    Abstract: The stability of a triplex in a solution is enhanced by adding to the solution, either before or after formation of the triplex, an effective amount of either of the following: (a) a water structure-making substance other than an alkali or alkaline earth metal cation, a tetramethylammonium cation, or a polyamine; or (b) a combination of said water structure-making substance and an alkali or alkaline earth cation. a tetramethylammonium cation, or a polyamine.
    Type: Application
    Filed: July 2, 1999
    Publication date: September 26, 2002
    Inventors: JACQUES R. FRESCO, JOHN LAURENCE RICHARD LAVELLE
  • Residues for binding third strands to complementary nucleic acid duplexes of any base pair sequence
    Patent number: 6426407
    Abstract: The invention relates to compositions of matter capable of serving as residues for specific binding of third strands to double-stranded complementary nucleic acids of any base-pair sequence.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 30, 2002
    Assignees: Codon Pharm., Princeton Univ.
    Inventors: Jacques R. Fresco, Bin Liu, Lynn C. Klotz
  • Triple-stranded nucleic acids
    Patent number: 5928863
    Abstract: A triple-stranded nucleic acid having a first nucleic acid strand that has a region of adjacent purine nucleoside residues; a second nucleic acid strand, at least a portion of which is hydrogen bonded in a Watson-Crick manner to the region of adjacent purine nucleoside residues of the first strand; and a third nucleic acid strand, at least a portion of which is hydrogen bonded to the portion of the region of adjacent purine nucleoside residues of the first strand, the portion of the region of adjacent purine nucleoside residues to which both the second strand and the third strand are bonded defining the triple-stranded nucleic acid.
    Type: Grant
    Filed: February 27, 1992
    Date of Patent: July 27, 1999
    Assignee: Princeton University
    Inventor: Jacques R. Fresco
  • Triple stranded nucleic acids
    Patent number: 5693471
    Abstract: A triple-stranded nucleic acid having a first nucleic acid strand that has a region of adjacent purine nucleoside residues; a second nucleic acid strand, at least a portion of which is hydrogen bonded in a Watson-Crick manner to the region of adjacent purine nucleoside residues of the first strand; and a third nucleic acid strand, at least a portion of which is hydrogen bonded to the portion of the region of adjacent purine nucleoside residues of the first strand, the portion of the region of adjacent purine nucleoside residues to which both the second strand and the third strand are bonded defining the triple-stranded nucleic acid is disclosed.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: December 2, 1997
    Assignee: Princeton University
    Inventor: Jacques R. Fresco
  • Triple-stranded nucleic acids
    Patent number: 5422251
    Abstract: A triple-stranded nucleic acid having a first nucleic acid strand that has a region of adjacent purine nucleoside residues; a second nucleic acid strand, at least a portion of which is hydrogen bonded in a Watson-Crick manner to the region of adjacent purine nucleoside residues of the first strand; and a third nucleic acid strand, at least a portion of which is hydrogen bonded to the portion of the region of adjacent purine nucleoside residues of the first strand, the portion of the region of adjacent purine nucleoside residues to which both the second strand and the third strand are bonded defining the triple-stranded nucleic acid.
    Type: Grant
    Filed: January 28, 1994
    Date of Patent: June 6, 1995
    Assignee: Princeton University
    Inventor: Jacques R. Fresco